OIT3 (oncoprotein induced transcript 3) - Rat Genome Database

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Gene: OIT3 (oncoprotein induced transcript 3) Homo sapiens
Analyze
Symbol: OIT3
Name: oncoprotein induced transcript 3
RGD ID: 1345970
HGNC Page HGNC:29953
Description: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within renal system process. Predicted to be located in nuclear envelope.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ39116; liver-specific zona pellucida domain-containing protein; liver-specific ZP domain-containing protein; LZP; oncoprotein-induced transcript 3 protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,893,739 - 72,933,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,893,584 - 72,933,036 (+)EnsemblGRCh38hg38GRCh38
GRCh371074,653,497 - 74,692,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,323,345 - 74,362,793 (+)NCBINCBI36Build 36hg18NCBI36
Build 341074,323,344 - 74,362,793NCBI
Celera1067,938,478 - 67,977,926 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,647,180 - 68,686,628 (+)NCBIHuRef
CHM1_11074,935,069 - 74,974,517 (+)NCBICHM1_1
T2T-CHM13v2.01073,765,121 - 73,804,414 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Xu ZG, etal., Hepatology 2003 Sep;38(3):735-44.
Additional References at PubMed
PMID:12477932   PMID:12975309   PMID:14702039   PMID:15589826   PMID:16344560   PMID:18830570   PMID:21873635   PMID:25416956   PMID:25824785   PMID:30561431   PMID:32296183   PMID:32569156  
PMID:33961781   PMID:35256949   PMID:35353239   PMID:37201744  


Genomics

Comparative Map Data
OIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,893,739 - 72,933,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,893,584 - 72,933,036 (+)EnsemblGRCh38hg38GRCh38
GRCh371074,653,497 - 74,692,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,323,345 - 74,362,793 (+)NCBINCBI36Build 36hg18NCBI36
Build 341074,323,344 - 74,362,793NCBI
Celera1067,938,478 - 67,977,926 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,647,180 - 68,686,628 (+)NCBIHuRef
CHM1_11074,935,069 - 74,974,517 (+)NCBICHM1_1
T2T-CHM13v2.01073,765,121 - 73,804,414 (+)NCBIT2T-CHM13v2.0
Oit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,258,782 - 59,277,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,258,780 - 59,277,600 (-)EnsemblGRCm39 Ensembl
GRCm381059,422,960 - 59,441,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,422,958 - 59,441,778 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,885,708 - 58,904,527 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,818,317 - 58,837,136 (-)NCBIMGSCv36mm8
Celera1060,523,229 - 60,542,048 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
Oit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,933,106 - 27,953,683 (-)NCBIGRCr8
mRatBN7.22027,390,113 - 27,410,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,390,113 - 27,410,692 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,400,328 - 28,420,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,786,586 - 27,807,100 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,531,213 - 28,551,727 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,009,330 - 29,029,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,009,330 - 29,029,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,813,656 - 30,834,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,833,503 - 28,854,112 (-)NCBICelera
Cytogenetic Map20q11NCBI
Oit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,718,242 - 18,745,434 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,721,556 - 18,745,369 (-)NCBIChiLan1.0ChiLan1.0
OIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,069,150 - 85,113,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,072,594 - 85,113,387 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,440,607 - 69,480,590 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,904,414 - 71,943,923 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,904,656 - 71,943,418 (+)Ensemblpanpan1.1panPan2
OIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,513,591 - 23,539,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,513,680 - 23,538,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,652,036 - 23,678,078 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,799,593 - 23,826,095 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,799,664 - 23,825,413 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,698,806 - 23,724,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,897,552 - 23,923,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,252,621 - 24,278,872 (+)NCBIUU_Cfam_GSD_1.0
Oit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,605,060 - 57,631,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,098,111 - 6,123,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,098,071 - 6,123,740 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,726,364 - 75,754,331 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,726,353 - 75,753,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,796,365 - 81,818,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,338,703 - 58,378,492 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,337,958 - 58,377,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,937,802 - 18,978,339 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,624,353 - 6,654,282 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,624,612 - 6,652,039 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OIT3
34 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2		 pathogenic
GRCh38/hg38 10q22.1-22.2(chr10:72720628-75612374)x1 copy number loss See cases [RCV000052531] Chr10:72720628..75612374 [GRCh38]
Chr10:74480386..77372132 [GRCh37]
Chr10:74150392..77042138 [NCBI36]
Chr10:10q22.1-22.2		 pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2		 pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2		 pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3		 pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2		 pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2		 pathogenic
NM_152635.3(OIT3):c.1598C>T (p.Thr533Met) single nucleotide variant Malignant tumor of prostate [RCV000205640] Chr10:72932484 [GRCh38]
Chr10:74692242 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_152635.3(OIT3):c.304C>T (p.Arg102Cys) single nucleotide variant Inborn genetic diseases [RCV003277180] Chr10:72898906 [GRCh38]
Chr10:74658664 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
NM_152635.3(OIT3):c.902C>T (p.Thr301Ile) single nucleotide variant Inborn genetic diseases [RCV003282094] Chr10:72913419 [GRCh38]
Chr10:74673177 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.326A>G (p.Asn109Ser) single nucleotide variant Inborn genetic diseases [RCV003295452] Chr10:72898928 [GRCh38]
Chr10:74658686 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_152635.3(OIT3):c.1339G>T (p.Val447Phe) single nucleotide variant Inborn genetic diseases [RCV003244612] Chr10:72924616 [GRCh38]
Chr10:74684374 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q21.3-22.3(chr10:68735254-78885714) copy number loss not specified [RCV002052875] Chr10:68735254..78885714 [GRCh37]
Chr10:10q21.3-22.3		 pathogenic
GRCh37/hg19 10q22.1-22.2(chr10:74472028-75007588) copy number gain not specified [RCV002052877] Chr10:74472028..75007588 [GRCh37]
Chr10:10q22.1-22.2		 uncertain significance
GRCh37/hg19 10q22.1(chr10:74573522-74852531)x3 copy number gain not provided [RCV001834524] Chr10:74573522..74852531 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.49G>A (p.Val17Met) single nucleotide variant Inborn genetic diseases [RCV002990096] Chr10:72893847 [GRCh38]
Chr10:74653605 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.159C>G (p.Asn53Lys) single nucleotide variant Inborn genetic diseases [RCV002733743] Chr10:72898761 [GRCh38]
Chr10:74658519 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.827A>C (p.Asn276Thr) single nucleotide variant Inborn genetic diseases [RCV002685069] Chr10:72913344 [GRCh38]
Chr10:74673102 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.398T>G (p.Leu133Arg) single nucleotide variant Inborn genetic diseases [RCV002708318] Chr10:72899000 [GRCh38]
Chr10:74658758 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.719G>C (p.Gly240Ala) single nucleotide variant Inborn genetic diseases [RCV003001765] Chr10:72911768 [GRCh38]
Chr10:74671526 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.1619G>A (p.Arg540His) single nucleotide variant Inborn genetic diseases [RCV002951746] Chr10:72932505 [GRCh38]
Chr10:74692263 [GRCh37]
Chr10:10q22.1		 likely benign
NM_152635.3(OIT3):c.59T>C (p.Val20Ala) single nucleotide variant Inborn genetic diseases [RCV002703886] Chr10:72893857 [GRCh38]
Chr10:74653615 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.460G>A (p.Asp154Asn) single nucleotide variant Inborn genetic diseases [RCV003001122] Chr10:72900400 [GRCh38]
Chr10:74660158 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.58G>A (p.Val20Met) single nucleotide variant Inborn genetic diseases [RCV002985109] Chr10:72893856 [GRCh38]
Chr10:74653614 [GRCh37]
Chr10:10q22.1		 likely benign
NM_152635.3(OIT3):c.494G>A (p.Cys165Tyr) single nucleotide variant Inborn genetic diseases [RCV002930718] Chr10:72900434 [GRCh38]
Chr10:74660192 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.4C>T (p.Pro2Ser) single nucleotide variant Inborn genetic diseases [RCV002930044] Chr10:72893802 [GRCh38]
Chr10:74653560 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.412G>A (p.Val138Ile) single nucleotide variant Inborn genetic diseases [RCV002789678] Chr10:72899014 [GRCh38]
Chr10:74658772 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.635G>A (p.Arg212His) single nucleotide variant Inborn genetic diseases [RCV002936808] Chr10:72906686 [GRCh38]
Chr10:74666444 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.799T>G (p.Leu267Val) single nucleotide variant Inborn genetic diseases [RCV002935796] Chr10:72913316 [GRCh38]
Chr10:74673074 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.502G>A (p.Ala168Thr) single nucleotide variant Inborn genetic diseases [RCV002717986] Chr10:72900442 [GRCh38]
Chr10:74660200 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.1048C>G (p.Leu350Val) single nucleotide variant Inborn genetic diseases [RCV002655951] Chr10:72924325 [GRCh38]
Chr10:74684083 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.262C>A (p.Leu88Ile) single nucleotide variant Inborn genetic diseases [RCV003216227] Chr10:72898864 [GRCh38]
Chr10:74658622 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.1105G>A (p.Val369Ile) single nucleotide variant Inborn genetic diseases [RCV003174364] Chr10:72924382 [GRCh38]
Chr10:74684140 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.457G>A (p.Glu153Lys) single nucleotide variant Inborn genetic diseases [RCV003174332] Chr10:72900397 [GRCh38]
Chr10:74660155 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.1516C>T (p.Arg506Cys) single nucleotide variant Inborn genetic diseases [RCV003173520] Chr10:72932402 [GRCh38]
Chr10:74692160 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.683A>G (p.His228Arg) single nucleotide variant Inborn genetic diseases [RCV003175565] Chr10:72911732 [GRCh38]
Chr10:74671490 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_152635.3(OIT3):c.1052T>C (p.Leu351Pro) single nucleotide variant Inborn genetic diseases [RCV003287835] Chr10:72924329 [GRCh38]
Chr10:74684087 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
NM_152635.3(OIT3):c.752G>A (p.Arg251Gln) single nucleotide variant Inborn genetic diseases [RCV003356549] Chr10:72911801 [GRCh38]
Chr10:74671559 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
NM_152635.3(OIT3):c.198G>A (p.Ala66=) single nucleotide variant not provided [RCV003417493] Chr10:72898800 [GRCh38]
Chr10:74658558 [GRCh37]
Chr10:10q22.1		 likely benign
NM_152635.3(OIT3):c.501C>T (p.Cys167=) single nucleotide variant not provided [RCV003417494] Chr10:72900441 [GRCh38]
Chr10:74660199 [GRCh37]
Chr10:10q22.1		 likely benign
GRCh37/hg19 10q22.1-22.2(chr10:74472028-75019111)x3 copy number gain not specified [RCV003986877] Chr10:74472028..75019111 [GRCh37]
Chr10:10q22.1-22.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:210
Interacting mature miRNAs:215
Transcripts:ENST00000334011
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D10S1146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,659,314 - 74,659,555UniSTSGRCh37
GRCh371074,658,005 - 74,659,555UniSTSGRCh37
Build 361074,329,320 - 74,329,561RGDNCBI36
Celera1067,944,453 - 67,944,694RGD
Celera1067,943,144 - 67,944,694UniSTS
Cytogenetic Map10q22.1UniSTS
HuRef1068,653,155 - 68,653,396UniSTS
HuRef1068,651,846 - 68,653,396UniSTS
Marshfield Genetic Map1093.92UniSTS
Marshfield Genetic Map1093.92RGD
D10S1432  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,659,396 - 74,659,569UniSTSGRCh37
Build 361074,329,402 - 74,329,575RGDNCBI36
Celera1067,944,535 - 67,944,708RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,653,237 - 68,653,410UniSTS
Marshfield Genetic Map1093.92RGD
Marshfield Genetic Map1093.92UniSTS
TNG Radiation Hybrid Map1034073.0UniSTS
deCODE Assembly Map1093.97UniSTS
Stanford-G3 RH Map103416.0UniSTS
Whitehead-RH Map10455.1UniSTS
Whitehead-YAC Contig Map10 UniSTS
RH70386  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,660,424 - 74,660,552UniSTSGRCh37
Build 361074,330,430 - 74,330,558RGDNCBI36
Celera1067,945,563 - 67,945,691RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,654,265 - 68,654,393UniSTS
GeneMap99-GB4 RH Map10379.16UniSTS
RH81037  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,692,536 - 74,692,772UniSTSGRCh37
Build 361074,362,542 - 74,362,778RGDNCBI36
Celera1067,977,675 - 67,977,911RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,686,377 - 68,686,613UniSTS
GeneMap99-GB4 RH Map10376.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 7 32 290 290 108 290 1 1 17 16 2 1
Low 343 487 247 155 363 149 63 16 394 177 432 207 7 39 20
Below cutoff 1439 1987 992 158 847 19 3051 1520 2127 159 730 1157 144 880 2029 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000334011   ⟹   ENSP00000333900
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1072,893,739 - 72,933,036 (+)Ensembl
RefSeq Acc Id: ENST00000622652   ⟹   ENSP00000479787
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1072,893,584 - 72,932,689 (+)Ensembl
RefSeq Acc Id: NM_152635   ⟹   NP_689848
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,893,739 - 72,933,036 (+)NCBI
GRCh371074,653,339 - 74,692,787 (+)RGD
Build 361074,323,345 - 74,362,793 (+)NCBI Archive
Celera1067,938,478 - 67,977,926 (+)RGD
HuRef1068,647,180 - 68,686,628 (+)ENTREZGENE
CHM1_11074,935,044 - 74,974,524 (+)NCBI
T2T-CHM13v2.01073,765,121 - 73,804,414 (+)NCBI
Sequence:
RefSeq Acc Id: NR_130125
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,893,739 - 72,933,036 (+)NCBI
CHM1_11074,935,044 - 74,974,524 (+)NCBI
T2T-CHM13v2.01073,765,121 - 73,804,414 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_689848   ⟸   NM_152635
- Peptide Label: precursor
- UniProtKB: A0AVP3 (UniProtKB/Swiss-Prot),   Q8N1M8 (UniProtKB/Swiss-Prot),   Q8WWZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000479787   ⟸   ENST00000622652
RefSeq Acc Id: ENSP00000333900   ⟸   ENST00000334011
Protein Domains
EGF-like   ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8WWZ8-F1-model_v2 AlphaFold Q8WWZ8 1-545 view protein structure

Promoters
RGD ID:7217823
Promoter ID:EPDNEW_H14657
Type:multiple initiation site
Name:OIT3_1
Description:oncoprotein induced transcript 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,893,586 - 72,893,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29953 AgrOrtholog
COSMIC OIT3 COSMIC
Ensembl Genes ENSG00000138315 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000334011 ENTREZGENE
  ENST00000334011.10 UniProtKB/Swiss-Prot
  ENST00000622652.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot
GTEx ENSG00000138315 GTEx
HGNC ID HGNC:29953 ENTREZGENE
Human Proteome Map OIT3 Human Proteome Map
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  ZP-C UniProtKB/Swiss-Prot
  ZP_chr UniProtKB/Swiss-Prot
  ZP_dom UniProtKB/Swiss-Prot
KEGG Report hsa:170392 UniProtKB/Swiss-Prot
NCBI Gene 170392 ENTREZGENE
OMIM 609330 OMIM
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/Swiss-Prot
  ONCOPROTEIN-INDUCED TRANSCRIPT 3 PROTEIN UniProtKB/Swiss-Prot
Pfam FXa_inhibition UniProtKB/Swiss-Prot
  Zona_pellucida UniProtKB/Swiss-Prot
PharmGKB PA142671231 PharmGKB
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  ZP_2 UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  SM00241 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
UniProt A0AVP3 ENTREZGENE
  OIT3_HUMAN UniProtKB/Swiss-Prot
  Q8N1M8 ENTREZGENE
  Q8WWZ8 ENTREZGENE
UniProt Secondary A0AVP3 UniProtKB/Swiss-Prot
  Q8N1M8 UniProtKB/Swiss-Prot