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Gene: ROBO4 (roundabout guidance receptor 4) Homo sapiens
Symbol: ROBO4
Name: roundabout guidance receptor 4
Description: Predicted to have cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Localizes to extracellular exosome. Implicated in bicuspid aortic valve disease; INTERACTS WITH 17beta-estradiol; aflatoxin B1; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AOVD3; ECSM4; FLJ20798; MGC133352; MGC133353; MRB; roundabout homolog 4; roundabout homolog 4, magic roundabout; roundabout, axon guidance receptor, homolog 4
Mus musculus (house mouse) : Robo4 (roundabout guidance receptor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Robo4 (roundabout guidance receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Robo4 (roundabout guidance receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ROBO4 (roundabout guidance receptor 4)
Canis lupus familiaris (dog) : ROBO4 (roundabout guidance receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Robo4 (roundabout guidance receptor 4)
Sus scrofa (pig) : ROBO4 (roundabout guidance receptor 4)
Chlorocebus sabaeus (African green monkey) : ROBO4 (roundabout guidance receptor 4)
Heterocephalus glaber (naked mole-rat) : Robo4 (roundabout guidance receptor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11124,883,691 - 124,898,500 (-)EnsemblGRCh38hg38GRCh38
GRCh3811124,883,691 - 124,897,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711124,754,114 - 124,767,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,259,324 - 124,272,950 (-)NCBINCBI36hg18NCBI36
Build 3411124,259,324 - 124,272,951NCBI
Celera11121,914,289 - 121,928,006 (-)NCBI
Cytogenetic Map11q24.2NCBI
HuRef11120,696,466 - 120,710,183 (-)NCBIHuRef
CHM1_111124,640,224 - 124,653,941 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ROBO4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345935
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.