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Gene: CCL3L1 (C-C motif chemokine ligand 3 like 1) Homo sapiens
Symbol: CCL3L1
Name: C-C motif chemokine ligand 3 like 1
Description: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 464.2; C-C motif chemokine 3-like 1; CCL3L3; chemokine (C-C motif) ligand 3-like 1; D17S1718; G0/G1 switch regulatory protein 19-2; G0S19-2; LD78; LD78-beta(1-70); LD78BETA; MGC104178; MGC12815; MGC182017; MIP1AP; PAT 464.2; SCYA3L; SCYA3L1; small inducible cytokine A3-like 1; small-inducible cytokine A3-like 1; tonsillar lymphocyte LD78 beta protein
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: only annotated on alternate loci in reference assembly
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh371734,623,842 - 34,625,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,647,955 - 31,649,843 (-)NCBINCBI36hg18NCBI36
Cytogenetic Map17q21.1NCBI
CHM1_11734,592,044 - 34,593,932 (-)NCBICHM1_1

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CCL3L1
Alliance Gene
Ensembl Gene
JBrowse: hg19
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345914
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.