MANEA (mannosidase endo-alpha) - Rat Genome Database
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Gene: MANEA (mannosidase endo-alpha) Homo sapiens
Analyze
Symbol: MANEA
Name: mannosidase endo-alpha
RGD ID: 1345544
HGNC Page HGNC
Description: Predicted to have alpha-mannosidase activity. Localizes to Golgi apparatus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha 1,2-endomannosidase; DKFZp686D20120; ENDO; endo-alpha mannosidase; endomannosidase; FLJ12838; glycoprotein endo-alpha-1,2-mannosidase; hEndo; mandaselin; mannosidase, endo-alpha
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl695,577,535 - 95,609,452 (+)EnsemblGRCh38hg38GRCh38
GRCh38695,577,535 - 95,609,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37696,025,373 - 96,057,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36696,132,134 - 96,164,047 (+)NCBINCBI36hg18NCBI36
Build 34696,132,133 - 96,164,047NCBI
Celera696,666,751 - 96,698,498 (+)NCBI
Cytogenetic Map6q16.1NCBI
HuRef693,458,650 - 93,490,603 (+)NCBIHuRef
CHM1_1696,287,324 - 96,319,327 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1736542   PMID:2187500   PMID:2541446   PMID:2542563   PMID:2649653   PMID:2829950   PMID:3099781   PMID:3264072   PMID:8093218   PMID:8673525   PMID:9109416   PMID:9361017  
PMID:11076863   PMID:11230166   PMID:11530211   PMID:12477932   PMID:12560567   PMID:14574404   PMID:14702039   PMID:15489336   PMID:15677381   PMID:15760709   PMID:16381901   PMID:16696976  
PMID:16733250   PMID:18029348   PMID:18438686   PMID:19255376   PMID:20379614   PMID:21873635   PMID:24473444   PMID:24967714   PMID:26186194   PMID:28514442   PMID:30745168  


Genomics

Comparative Map Data
MANEA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl695,577,535 - 95,609,452 (+)EnsemblGRCh38hg38GRCh38
GRCh38695,577,535 - 95,609,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37696,025,373 - 96,057,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36696,132,134 - 96,164,047 (+)NCBINCBI36hg18NCBI36
Build 34696,132,133 - 96,164,047NCBI
Celera696,666,751 - 96,698,498 (+)NCBI
Cytogenetic Map6q16.1NCBI
HuRef693,458,650 - 93,490,603 (+)NCBIHuRef
CHM1_1696,287,324 - 96,319,327 (+)NCBICHM1_1
Manea
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39426,324,506 - 26,346,913 (-)NCBIGRCm39mm39
GRCm38426,324,506 - 26,346,918 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl426,324,506 - 26,346,891 (-)EnsemblGRCm38mm10GRCm38
MGSCv37426,251,653 - 26,273,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv36426,415,136 - 26,437,282 (-)NCBImm8
Celera426,032,320 - 26,054,498 (-)NCBICelera
Cytogenetic Map4A3NCBI
Manea
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0540,845,103 - 40,867,025 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl540,844,998 - 40,867,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0545,469,290 - 45,491,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4541,577,651 - 41,590,456 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1541,576,728 - 41,590,474 (-)NCBI
Celera539,058,787 - 39,071,389 (-)NCBICelera
Cytogenetic Map5q21NCBI
Manea
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541121,735,550 - 21,761,750 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541121,729,085 - 21,763,684 (+)NCBIChiLan1.0ChiLan1.0
MANEA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1697,316,022 - 97,347,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl697,316,022 - 97,347,768 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0693,428,813 - 93,460,576 (+)NCBIMhudiblu_PPA_v0panPan3
MANEA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1254,170,184 - 54,225,013 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11254,156,398 - 54,229,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Manea
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366991,975,391 - 2,006,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MANEA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl162,887,881 - 62,945,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1162,887,689 - 62,945,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2171,027,088 - 71,084,858 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MANEA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11320,496,677 - 20,529,201 (+)NCBI
ChlSab1.1 Ensembl1320,496,686 - 20,530,819 (+)Ensembl
Manea
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248109,961,154 - 9,998,835 (-)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1133
Count of miRNA genes:665
Interacting mature miRNAs:738
Transcripts:ENST00000358812, ENST00000369293, ENST00000474553
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 153 352 231 151 630 152 813 55 235 199 256 373 11 1 379 315 4
Low 2284 2315 1492 472 1031 312 3465 2029 3484 217 1202 1237 164 824 2395 2 2
Below cutoff 2 323 2 289 79 113 15 3 2 3 1 78

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ577574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK022900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY048774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY048775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY372528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC146671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ018032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX481372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000358812   ⟹   ENSP00000351669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl695,577,535 - 95,609,452 (+)Ensembl
RefSeq Acc Id: ENST00000369293   ⟹   ENSP00000358299
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl695,577,543 - 95,587,381 (+)Ensembl
RefSeq Acc Id: ENST00000474553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl695,588,222 - 95,606,023 (+)Ensembl
RefSeq Acc Id: NM_024641   ⟹   NP_078917
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38695,577,535 - 95,609,452 (+)NCBI
GRCh37696,025,373 - 96,057,333 (+)NCBI
Build 36696,132,134 - 96,164,047 (+)NCBI Archive
HuRef693,458,650 - 93,490,603 (+)ENTREZGENE
CHM1_1696,287,324 - 96,319,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005267147   ⟹   XP_005267204
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38695,577,777 - 95,609,452 (+)NCBI
GRCh37696,025,373 - 96,057,333 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_078917   ⟸   NM_024641
- UniProtKB: Q5SRI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005267204   ⟸   XM_005267147
- Peptide Label: isoform X1
- UniProtKB: Q5SRI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000358299   ⟸   ENST00000369293
RefSeq Acc Id: ENSP00000351669   ⟸   ENST00000358812

Promoters
RGD ID:7208723
Promoter ID:EPDNEW_H10107
Type:initiation region
Name:MANEA_1
Description:mannosidase endo-alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38695,577,536 - 95,577,596EPDNEW
RGD ID:6804433
Promoter ID:HG_KWN:54390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000043644,   UC003PON.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36696,131,876 - 96,132,432 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q14.2-16.1(chr6:83838303-98822313)x1 copy number loss See cases [RCV000135773] Chr6:83838303..98822313 [GRCh38]
Chr6:84548022..99270189 [GRCh37]
Chr6:84604741..99376910 [NCBI36]
Chr6:6q14.2-16.1
pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh37/hg19 6q15-16.3(chr6:92576950-104658245)x1 copy number loss See cases [RCV000446720] Chr6:92576950..104658245 [GRCh37]
Chr6:6q15-16.3
pathogenic
GRCh37/hg19 6q16.1(chr6:95939436-96052357)x1 copy number loss See cases [RCV000446249] Chr6:95939436..96052357 [GRCh37]
Chr6:6q16.1
likely benign
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 copy number loss See cases [RCV000512470] Chr6:94202605..109878834 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1
pathogenic
GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 copy number gain not provided [RCV000682688] Chr6:81261418..97796269 [GRCh37]
Chr6:6q14.1-16.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q15-16.1(chr6:88783642-96282103)x3 copy number gain not provided [RCV000849950] Chr6:88783642..96282103 [GRCh37]
Chr6:6q15-16.1
uncertain significance
GRCh37/hg19 6q16.1(chr6:95956613-96263611)x1 copy number loss not provided [RCV001005833] Chr6:95956613..96263611 [GRCh37]
Chr6:6q16.1
uncertain significance
GRCh37/hg19 6q16.1(chr6:96028232-97247130)x1 copy number loss Microcephaly [RCV001251052] Chr6:96028232..97247130 [GRCh37]
Chr6:6q16.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21072 AgrOrtholog
COSMIC MANEA COSMIC
Ensembl Genes ENSG00000172469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000351669 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358299 UniProtKB/TrEMBL
Ensembl Transcript ENST00000358812 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369293 UniProtKB/TrEMBL
GTEx ENSG00000172469 GTEx
HGNC ID HGNC:21072 ENTREZGENE
Human Proteome Map MANEA Human Proteome Map
InterPro Glyco_Hydrolase_99 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report hsa:79694 UniProtKB/Swiss-Prot
NCBI Gene 79694 ENTREZGENE
OMIM 612327 OMIM
PANTHER PTHR13572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_99 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134891001 PharmGKB
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
UniProt MANEA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  X6R7A2_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6H8M6 UniProtKB/Swiss-Prot
  Q5SRJ0 UniProtKB/Swiss-Prot
  Q6MZV0 UniProtKB/Swiss-Prot
  Q70JE9 UniProtKB/Swiss-Prot
  Q7Z3V7 UniProtKB/Swiss-Prot
  Q8WWX5 UniProtKB/Swiss-Prot
  Q9H9D2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 MANEA  mannosidase endo-alpha    mannosidase, endo-alpha  Symbol and/or name change 5135510 APPROVED
2011-08-17 MANEA  mannosidase, endo-alpha  MANEA  mannosidase, endo-alpha  Symbol and/or name change 5135510 APPROVED