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Gene: CKMT1B (creatine kinase, mitochondrial 1B) Homo sapiens
Symbol: CKMT1B
Name: creatine kinase, mitochondrial 1B
Description: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acidic-type mitochondrial creatine kinase; CKMT; CKMT1; CKMT1A; creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1 (ubiquitous); mia-CK; U-MtCK; ubiquitous mitochondrial creatine kinase; UMTCK
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381543,592,857 - 43,599,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371543,885,055 - 43,891,604 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,672,544 - 41,678,896 (+)NCBINCBI36hg18NCBI36
Build 341541,673,545 - 41,678,874NCBI
Celera1520,779,315 - 20,779,894 (+)NCBI
Cytogenetic Map15q15.3NCBI
HuRef1520,807,783 - 20,814,119 (+)NCBIHuRef
CHM1_11544,003,044 - 44,009,651 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CKMT1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345536
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.