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Gene: GDF5 (growth differentiation factor 5) Homo sapiens
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Symbol: GDF5
Name: growth differentiation factor 5
Description: Exhibits BMP binding activity and identical protein binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of chondrocyte differentiation; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to the extracellular space. Implicated in Parkinson's disease; bone disease (multiple); and proximal symphalangism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDA1C; BMP-14; BMP14; bone morphogenetic protein 14; cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; CDMP1; GDF-5; growth/differentiation factor 5; LAP-4; LAP4; lipopolysaccharide-associated protein 4; LPS-associated protein 4; OS5; radotermin; SYM1B; SYNS2
Orthologs:
Mus musculus (house mouse) : Gdf5 (growth differentiation factor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gdf5 (growth differentiation factor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf5 (growth differentiation factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF5 (growth differentiation factor 5)
Canis lupus familiaris (dog) : GDF5 (growth differentiation factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf5 (growth differentiation factor 5)
Sus scrofa (pig) : GDF5 (growth differentiation factor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2035,433,347 - 35,454,746 (-)Ensembl
GRCh382035,433,347 - 35,454,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372034,021,149 - 34,026,027 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,484,563 - 33,489,441 (-)NCBINCBI36hg18NCBI36
Build 342033,484,562 - 33,489,441NCBI
Celera2030,769,772 - 30,774,651 (-)NCBI
Cytogenetic Map20q11.22NCBI
HuRef2030,798,624 - 30,803,509 (-)NCBIHuRef
CHM1_12033,922,575 - 33,943,940 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
 
More on GDF5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345266
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.