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Gene: PSME4 (proteasome activator subunit 4) Homo sapiens
Symbol: PSME4
Name: proteasome activator subunit 4
Description: Predicted to have lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Localizes to nucleoplasm; PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH (-)-demecolcine; 1-nitropyrene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ21864; KIAA0077; MGC138374; MGC142228; PA200; proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; proteasome activator complex subunit 4; proteasome activator PA200
Mus musculus (house mouse) : Psme4 (proteasome (prosome, macropain) activator subunit 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Psme4 (proteasome activator subunit 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psme4 (proteasome activator subunit 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PSME4 (proteasome activator subunit 4)
Canis lupus familiaris (dog) : PSME4 (proteasome activator subunit 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psme4 (proteasome activator subunit 4)
Sus scrofa (pig) : PSME4 (proteasome activator subunit 4)
Chlorocebus sabaeus (African green monkey) : PSME4 (proteasome activator subunit 4)
Heterocephalus glaber (naked mole-rat) : Psme4 (proteasome activator subunit 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl253,864,069 - 53,970,993 (-)EnsemblGRCh38hg38GRCh38
GRCh38253,864,069 - 53,970,993 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37254,091,204 - 54,197,977 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,945,075 - 54,051,354 (-)NCBINCBI36hg18NCBI36
Celera253,932,066 - 54,038,835 (-)NCBI
Cytogenetic Map2p16.2NCBI
HuRef253,825,271 - 53,932,895 (-)NCBIHuRef
CHM1_1254,022,073 - 54,128,847 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PSME4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345096
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.