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Gene: PLEKHA1 (pleckstrin homology domain containing A1) Homo sapiens
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Symbol: PLEKHA1
Name: pleckstrin homology domain containing A1
Description: Exhibits PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including B cell receptor signaling pathway; negative regulation of protein kinase B signaling; and phosphatidylinositol 3-kinase signaling. Localizes to the cytosol; nucleoplasm; and ruffle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 1; tandem PH domain containing protein-1; tandem PH domain-containing protein 1; TAPP-1; TAPP1
Orthologs:
Mus musculus (house mouse) : Plekha1 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plekha1 (pleckstrin homology domain containing A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plekha1 (pleckstrin homology domain containing A1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLEKHA1 (pleckstrin homology domain containing A1)
Canis lupus familiaris (dog) : PLEKHA1 (pleckstrin homology domain containing A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plekha1 (pleckstrin homology domain containing A1)
Sus scrofa (pig) : PLEKHA1 (pleckstrin homology domain containing A1)
Chlorocebus sabaeus (African green monkey) : PLEKHA1 (pleckstrin homology domain containing A1)
Heterocephalus glaber (naked mole-rat) : Plekha1 (pleckstrin homology domain containing A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10122,374,696 - 122,442,602 (+)Ensembl
GRCh3810122,374,675 - 122,442,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710124,134,094 - 124,191,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,124,210 - 124,181,856 (+)NCBINCBI36hg18NCBI36
Build 3410124,141,832 - 124,181,856NCBI
Celera10117,866,583 - 117,924,124 (+)NCBI
Cytogenetic Map10q26.13NCBI
HuRef10117,764,924 - 117,822,671 (+)NCBIHuRef
CHM1_110124,418,717 - 124,476,463 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

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Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on PLEKHA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345011
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.