MIR127 (microRNA 127) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MIR127 (microRNA 127) Homo sapiens
Analyze
Symbol: MIR127
Name: microRNA 127
RGD ID: 1344992
Description: Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; long-term synaptic potentiation; and regulation of gene expression, epigenetic.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-127; MIRN127; miRNA127
Orthologs:
Mus musculus (house mouse) : Mir127 (microRNA 127)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mir127 (microRNA 127)  Alliance
Canis lupus familiaris (dog) : MIR127 (microRNA mir-127)
Sus scrofa (pig) : MIR127 (microRNA mir-127)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14100,882,979 - 100,883,075 (+)EnsemblGRCh38hg38GRCh38
GRCh3814100,882,979 - 100,883,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,349,316 - 101,349,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,419,068 - 100,419,164 (+)NCBINCBI36hg18NCBI36
Celera1481,403,135 - 81,403,231 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1481,531,047 - 81,531,143 (+)NCBIHuRef
CHM1_114101,287,504 - 101,287,600 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

Additional References at PubMed
PMID:12007417   PMID:15891114   PMID:16381832   PMID:16766263   PMID:17604727   PMID:18230126   PMID:19287466   PMID:19530237   PMID:19946636   PMID:20889907   PMID:21037258   PMID:22433606  
PMID:23762330   PMID:23880861   PMID:24022470   PMID:24155205   PMID:24194846   PMID:24282530   PMID:24604520   PMID:24854842   PMID:25477702   PMID:25701838   PMID:26261488   PMID:26646931  
PMID:26655997   PMID:26707641   PMID:26708147   PMID:27126955   PMID:27571739   PMID:27571744   PMID:27645894   PMID:27998789   PMID:28559201   PMID:28590075   PMID:28636101   PMID:28866093  
PMID:29434409   PMID:29573114   PMID:29979259   PMID:30579595   PMID:30720171   PMID:31252264   PMID:31562641   PMID:31694904   PMID:32051829  


Genomics

Comparative Map Data
MIR127
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14100,882,979 - 100,883,075 (+)EnsemblGRCh38hg38GRCh38
GRCh3814100,882,979 - 100,883,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714101,349,316 - 101,349,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,419,068 - 100,419,164 (+)NCBINCBI36hg18NCBI36
Celera1481,403,135 - 81,403,231 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1481,531,047 - 81,531,143 (+)NCBIHuRef
CHM1_114101,287,504 - 101,287,600 (+)NCBICHM1_1
Mir127
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,559,280 - 109,559,349 (+)NCBI
GRCm3812109,592,846 - 109,592,915 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,592,846 - 109,592,915 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,831,056 - 110,831,125 (+)NCBIGRCm37mm9NCBIm37
Celera12110,787,547 - 110,787,616 (+)NCBICelera
Cytogenetic Map12F1NCBI
Mir127
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06133,713,430 - 133,713,526 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,713,430 - 133,713,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,875,607 - 142,875,703 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,094,654 - 126,094,750 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl869,104,906 - 69,105,016 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1869,104,938 - 69,104,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR127
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,709,640 - 121,709,720 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,709,636 - 121,709,715 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27132,099,553 - 132,099,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
MARC_10877-10878:993140164:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3714101,348,393 - 101,349,385UniSTSGRCh37
Celera1481,402,212 - 81,403,204UniSTS
HuRef1481,530,124 - 81,531,116UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PRDM1hsa-miR-127-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19530237
XBP1hsa-miR-127-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19530237
BCL6hsa-miR-127-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17581274
BCL6hsa-miR-127-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI16766263
KMT5Ahsa-miR-127-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22720056
PRDM1hsa-miR-127-3pMirecordsexternal_info{changed}NA19530237
CXCL12hsa-miR-127-3pOncomiRDBexternal_infoNANA21343399
PRDM1hsa-miR-127-3pOncomiRDBexternal_infoNANA19530237

Predicted Targets
Summary Value
Count of predictions:24235
Count of gene targets:10292
Count of transcripts:19797
Interacting mature miRNAs:hsa-miR-127-3p, hsa-miR-127-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 1 1
Low 3 5 4 9 26 4 8
Below cutoff 2 2 1 9 5 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384876
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl14100,882,979 - 100,883,075 (+)Ensembl
RefSeq Acc Id: NR_029696
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814100,882,979 - 100,883,075 (+)NCBI
GRCh3714101,349,316 - 101,349,412 (+)RGD
Celera1481,403,135 - 81,403,231 (+)RGD
HuRef1481,531,047 - 81,531,143 (+)ENTREZGENE
CHM1_114101,287,504 - 101,287,600 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:99794337-100944567)x1 copy number loss See cases [RCV000141596] Chr14:99794337..100944567 [GRCh38]
Chr14:100260674..101410904 [GRCh37]
Chr14:99330427..100480657 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:99930669-101022599)x1 copy number loss See cases [RCV000142774] Chr14:99930669..101022599 [GRCh38]
Chr14:100397006..101488936 [GRCh37]
Chr14:99466759..100558689 [NCBI36]
Chr14:14q32.2-32.31
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
NC_000014.9:g.100489287_100900640del411354 deletion Paternal uniparental disomy of chromosome 14 [RCV000149428] Chr14:100489287..100900640 [GRCh38]
Chr14:100955624..101366977 [GRCh37]
Chr14:14q32.2-32.31
pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:100575917-107281934) copy number gain not provided [RCV000767752] Chr14:100575917..107281934 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:98051841-107285437)x3 copy number gain See cases [RCV000446497] Chr14:98051841..107285437 [GRCh37]
Chr14:14q32.2-32.33
likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:100661319-107285437)x1 copy number loss See cases [RCV000511171] Chr14:100661319..107285437 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.31(chr14:99737888-101847855) copy number gain not provided [RCV000767823] Chr14:99737888..101847855 [GRCh37]
Chr14:14q32.2-32.31
likely pathogenic
GRCh37/hg19 14q32.12-32.33(chr14:91969028-107285437)x3 copy number gain not provided [RCV000848687] Chr14:91969028..107285437 [GRCh37]
Chr14:14q32.12-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:99794230-107285437)x3 copy number gain not provided [RCV000849272] Chr14:99794230..107285437 [GRCh37]
Chr14:14q32.2-32.33
pathogenic
GRCh37/hg19 14q32.2-32.33(chr14:96829290-107287663)x1 copy number loss See cases [RCV001195078] Chr14:96829290..107287663 [GRCh37]
Chr14:14q32.2-32.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31509 AgrOrtholog
COSMIC MIR127 COSMIC
Ensembl Genes ENSG00000207608 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384876 ENTREZGENE
GTEx ENSG00000207608 GTEx
HGNC ID HGNC:31509 ENTREZGENE
Human Proteome Map MIR127 Human Proteome Map
miRBase MI0000472 ENTREZGENE
NCBI Gene 406914 ENTREZGENE
OMIM 611709 OMIM
PharmGKB PA164722415 PharmGKB
RNAcentral URS0000007340 RNACentral
  URS00000A33DB RNACentral
  URS00001E3DAA RNACentral