IL25 (interleukin 25) - Rat Genome Database

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Gene: IL25 (interleukin 25) Homo sapiens
Analyze
Symbol: IL25
Name: interleukin 25
RGD ID: 1344819
HGNC Page HGNC:13765
Description: Predicted to enable interleukin-17E receptor binding activity. Predicted to be involved in inflammatory response to antigenic stimulus and signal transduction. Predicted to act upstream of or within several processes, including eosinophil differentiation; positive regulation of transcription by RNA polymerase II; and response to nematode. Predicted to be located in extracellular region. Biomarker of atopic dermatitis and psoriasis.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-17E; IL-25; IL17E; interleukin 17E; interleukin-17E; interleukin-25
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: GLUCO171_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,372,809 - 23,376,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,372,809 - 23,376,403 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,842,018 - 23,845,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,911,858 - 22,915,452 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,911,857 - 22,915,452NCBI
Celera143,704,729 - 3,708,323 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,958,437 - 3,962,031 (+)NCBIHuRef
CHM1_11423,840,690 - 23,844,284 (+)NCBICHM1_1
T2T-CHM13v2.01417,573,825 - 17,577,419 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. Ballantyne SJ, etal., J Allergy Clin Immunol. 2007 Dec;120(6):1324-31. doi: 10.1016/j.jaci.2007.07.051. Epub 2007 Sep 24.
2. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Beale J, etal., Sci Transl Med. 2014 Oct 1;6(256):256ra134. doi: 10.1126/scitranslmed.3009124.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. [Effects of acupuncture stimulation of different acupoint groups on sleeping latency, serum and hippocampal TNF-α and IL-25 contents in rats with gastric mucosal injury]. Huang YH, etal., Zhen Ci Yan Jiu. 2015 Apr;40(2):131-5.
5. IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication. Kim BE, etal., J Invest Dermatol. 2013 Dec;133(12):2678-2685. doi: 10.1038/jid.2013.223. Epub 2013 May 8.
6. Inhibitory effect of recombinant IL-25 on the development of dextran sulfate sodium-induced experimental colitis in mice. Mchenga SS, etal., Cell Mol Immunol. 2008 Dec;5(6):425-31. doi: 10.1038/cmi.2008.53.
7. Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis. Noor Z, etal., mBio. 2017 Feb 28;8(1). pii: mBio.02329-16. doi: 10.1128/mBio.02329-16.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11058597   PMID:11714825   PMID:11754819   PMID:12239140   PMID:12477932   PMID:12975309   PMID:15340161   PMID:15489334   PMID:16226712   PMID:16522458   PMID:16950278   PMID:17207965  
PMID:17635955   PMID:17719653   PMID:19095584   PMID:19129540   PMID:19329997   PMID:19968632   PMID:20237496   PMID:20492545   PMID:20729468   PMID:20861853   PMID:20944558   PMID:21205894  
PMID:21570719   PMID:21980299   PMID:22266274   PMID:22691357   PMID:23429464   PMID:23564603   PMID:23590308   PMID:23810766   PMID:23957336   PMID:24247484   PMID:24323357   PMID:24344271  
PMID:24746746   PMID:25133876   PMID:25676453   PMID:25704964   PMID:25705788   PMID:25903653   PMID:25975248   PMID:26321145   PMID:26347322   PMID:26356122   PMID:26540312   PMID:26762527  
PMID:26845056   PMID:26852387   PMID:27000993   PMID:27089063   PMID:27685606   PMID:27909985   PMID:28127565   PMID:28421819   PMID:28771607   PMID:28771767   PMID:28870448   PMID:28875265  
PMID:29257317   PMID:29337030   PMID:29653697   PMID:29966691   PMID:30022162   PMID:30334403   PMID:30345318   PMID:30738055   PMID:30997832   PMID:31200339   PMID:31641990   PMID:31697750  
PMID:31741433   PMID:31905037   PMID:31958433   PMID:32573420   PMID:32671514   PMID:32686186   PMID:32694731   PMID:32716065   PMID:32776912   PMID:33005030   PMID:33486314   PMID:33536745  
PMID:33766233   PMID:33961781   PMID:34122457   PMID:34264790   PMID:34443554   PMID:34944487   PMID:35008429   PMID:35171244   PMID:35277002   PMID:36082495   PMID:36119076   PMID:36263033  
PMID:36724073   PMID:37524666   PMID:37702163   PMID:37781372   PMID:38028847   PMID:38396704  


Genomics

Comparative Map Data
IL25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,372,809 - 23,376,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,372,809 - 23,376,403 (+)EnsemblGRCh38hg38GRCh38
GRCh371423,842,018 - 23,845,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,911,858 - 22,915,452 (+)NCBINCBI36Build 36hg18NCBI36
Build 341422,911,857 - 22,915,452NCBI
Celera143,704,729 - 3,708,323 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,958,437 - 3,962,031 (+)NCBIHuRef
CHM1_11423,840,690 - 23,844,284 (+)NCBICHM1_1
T2T-CHM13v2.01417,573,825 - 17,577,419 (+)NCBIT2T-CHM13v2.0
Il25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,170,152 - 55,173,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,170,152 - 55,173,294 (+)EnsemblGRCm39 Ensembl
GRCm381454,932,695 - 54,935,837 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,932,695 - 54,935,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371455,551,532 - 55,554,674 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,886,980 - 53,890,043 (+)NCBIMGSCv36mm8
Celera1452,738,886 - 52,742,027 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.0NCBI
Il25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,378,750 - 32,382,141 (+)NCBIGRCr8
mRatBN7.21528,408,766 - 28,412,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,408,842 - 28,411,893 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,254,511 - 30,257,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,401,713 - 31,404,548 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,644,433 - 29,647,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,594,852 - 33,599,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,596,301 - 33,599,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,483,323 - 37,486,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,035,230 - 33,038,064 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1527,986,647 - 27,989,481 (+)NCBICelera
Cytogenetic Map15p13NCBI
Il25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,961,398 - 36,964,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,960,902 - 36,964,038 (-)NCBIChiLan1.0ChiLan1.0
IL25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,804,487 - 24,807,642 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,020,977 - 24,024,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,191,888 - 4,195,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,286,347 - 22,289,498 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,286,347 - 22,289,498 (+)Ensemblpanpan1.1panPan2
IL25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,621,268 - 3,624,689 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,618,161 - 3,624,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,569,370 - 3,572,805 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,728,890 - 3,732,325 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,725,891 - 3,747,853 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,420,449 - 3,423,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,481,722 - 3,485,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,743,917 - 3,747,352 (+)NCBIUU_Cfam_GSD_1.0
Il25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,384,643 - 35,391,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722996,960 - 1,003,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722997,476 - 1,000,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,709,995 - 75,714,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,710,453 - 75,717,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,020,938 - 81,030,418 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,742,377 - 23,747,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,744,449 - 23,747,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,671,106 - 22,680,822 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,188,612 - 9,191,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,188,709 - 9,192,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL25
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:23260803-23763521)x3 copy number gain See cases [RCV000052058] Chr14:23260803..23763521 [GRCh38]
Chr14:23730012..24232730 [GRCh37]
Chr14:22799852..23302570 [NCBI36]
Chr14:14q11.2		 uncertain significance
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
NM_022789.3(IL25):c.6G>A (p.Arg2=) single nucleotide variant Malignant melanoma [RCV000070497] Chr14:23373124 [GRCh38]
Chr14:23842333 [GRCh37]
Chr14:22912173 [NCBI36]
Chr14:14q11.2		 not provided
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:19100682-28730087) copy number gain not provided [RCV000767822] Chr14:19100682..28730087 [GRCh37]
Chr14:14q11.2-12		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:19794561-27768254)x3 copy number gain See cases [RCV000240285] Chr14:19794561..27768254 [GRCh37]
Chr14:14q11.2-12		 pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3 copy number gain See cases [RCV000448273] Chr14:19794561..34049214 [GRCh37]
Chr14:14q11.2-13.1		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_172314.2(IL25):c.44A>C (p.His15Pro) single nucleotide variant Inborn genetic diseases [RCV003304538] Chr14:23373210 [GRCh38]
Chr14:23842419 [GRCh37]
Chr14:14q11.2		 uncertain significance
GRCh37/hg19 14q11.2(chr14:23840034-24057640)x1 copy number loss not provided [RCV000683589] Chr14:23840034..24057640 [GRCh37]
Chr14:14q11.2		 uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2(chr14:21717093-24027220)x3 copy number gain not provided [RCV000856644] Chr14:21717093..24027220 [GRCh37]
Chr14:14q11.2		 likely pathogenic
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3 copy number gain not provided [RCV001249358] Chr14:20511672..42881888 [GRCh37]
Chr14:14q11.2-21.1		 not provided
NC_000014.8:g.(?_23242819)_(25103366_?)dup duplication Lysinuric protein intolerance [RCV003105428]|Specific granule deficiency [RCV003105427] Chr14:23242819..25103366 [GRCh37]
Chr14:14q11.2-12		 uncertain significance
NC_000014.8:g.(?_23586696)_(23902941_?)del deletion Specific granule deficiency [RCV003107481] Chr14:23586696..23902941 [GRCh37]
Chr14:14q11.2		 pathogenic
NM_172314.2(IL25):c.376C>T (p.Arg126Trp) single nucleotide variant not provided [RCV000955204] Chr14:23375770 [GRCh38]
Chr14:23844979 [GRCh37]
Chr14:14q11.2		 benign
NM_172314.2(IL25):c.473G>A (p.Arg158His) single nucleotide variant not provided [RCV000973964] Chr14:23375867 [GRCh38]
Chr14:23845076 [GRCh37]
Chr14:14q11.2		 likely benign
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3 copy number gain not provided [RCV001006605] Chr14:20511672..44829030 [GRCh37]
Chr14:14q11.2-21.2		 pathogenic
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203) copy number gain Seizure [RCV002280625] Chr14:20511672..47481203 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NC_000014.8:g.(21162263_36986276)_(36987308_50713602)del deletion Brain-lung-thyroid syndrome [RCV002221171] Chr14:36986276..36987308 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NM_172314.2(IL25):c.55C>T (p.His19Tyr) single nucleotide variant Inborn genetic diseases [RCV002659739] Chr14:23373221 [GRCh38]
Chr14:23842430 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.349C>G (p.Leu117Val) single nucleotide variant Inborn genetic diseases [RCV002704479] Chr14:23375743 [GRCh38]
Chr14:23844952 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.410A>G (p.Lys137Arg) single nucleotide variant Inborn genetic diseases [RCV002767167] Chr14:23375804 [GRCh38]
Chr14:23845013 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.428G>T (p.Arg143Leu) single nucleotide variant Inborn genetic diseases [RCV002849905] Chr14:23375822 [GRCh38]
Chr14:23845031 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.65G>A (p.Ser22Asn) single nucleotide variant Inborn genetic diseases [RCV002640899] Chr14:23373231 [GRCh38]
Chr14:23842440 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.440G>A (p.Arg147His) single nucleotide variant Inborn genetic diseases [RCV002930252] Chr14:23375834 [GRCh38]
Chr14:23845043 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.382C>G (p.Pro128Ala) single nucleotide variant Inborn genetic diseases [RCV002832680] Chr14:23375776 [GRCh38]
Chr14:23844985 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.458T>C (p.Val153Ala) single nucleotide variant Inborn genetic diseases [RCV002677300] Chr14:23375852 [GRCh38]
Chr14:23845061 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.265C>G (p.Leu89Val) single nucleotide variant Inborn genetic diseases [RCV002724233] Chr14:23375659 [GRCh38]
Chr14:23844868 [GRCh37]
Chr14:14q11.2		 uncertain significance
NM_172314.2(IL25):c.394G>A (p.Glu132Lys) single nucleotide variant Inborn genetic diseases [RCV003175097] Chr14:23375788 [GRCh38]
Chr14:23844997 [GRCh37]
Chr14:14q11.2		 likely benign
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:679
Count of miRNA genes:487
Interacting mature miRNAs:522
Transcripts:ENST00000329715, ENST00000397242
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
IL17E_757  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,844,958 - 23,845,624UniSTSGRCh37
Build 361422,914,798 - 22,915,464RGDNCBI36
Celera143,707,669 - 3,708,335RGD
HuRef143,961,377 - 3,962,043UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 1 1 1
Low 2 163 12 7 292 92 59 351 18 25 186
Below cutoff 1167 1693 794 143 395 37 3077 1459 2806 80 668 865 107 894 2075

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000329715   ⟹   ENSP00000328111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,372,861 - 23,376,403 (+)Ensembl
RefSeq Acc Id: ENST00000397242   ⟹   ENSP00000380417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,372,809 - 23,376,403 (+)Ensembl
RefSeq Acc Id: NM_022789   ⟹   NP_073626
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,372,809 - 23,376,403 (+)NCBI
GRCh371423,842,018 - 23,845,612 (+)ENTREZGENE
Build 361422,911,858 - 22,915,452 (+)NCBI Archive
HuRef143,958,437 - 3,962,031 (+)ENTREZGENE
CHM1_11423,840,742 - 23,844,284 (+)NCBI
T2T-CHM13v2.01417,573,825 - 17,577,419 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172314   ⟹   NP_758525
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,372,809 - 23,376,403 (+)NCBI
GRCh371423,842,018 - 23,845,612 (+)ENTREZGENE
Build 361422,911,858 - 22,915,452 (+)NCBI Archive
HuRef143,958,437 - 3,962,031 (+)ENTREZGENE
CHM1_11423,840,690 - 23,844,284 (+)NCBI
T2T-CHM13v2.01417,573,825 - 17,577,419 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_758525   ⟸   NM_172314
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9H293 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_073626   ⟸   NM_022789
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8IZV3 (UniProtKB/Swiss-Prot),   Q2M3F0 (UniProtKB/Swiss-Prot),   Q8WXB0 (UniProtKB/Swiss-Prot),   Q9H293 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000328111   ⟸   ENST00000329715
RefSeq Acc Id: ENSP00000380417   ⟸   ENST00000397242

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H293-F1-model_v2 AlphaFold Q9H293 1-177 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13765 AgrOrtholog
COSMIC IL25 COSMIC
Ensembl Genes ENSG00000166090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000329715 ENTREZGENE
  ENST00000329715.2 UniProtKB/Swiss-Prot
  ENST00000397242 ENTREZGENE
  ENST00000397242.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
GTEx ENSG00000166090 GTEx
HGNC ID HGNC:13765 ENTREZGENE
Human Proteome Map IL25 Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  IL-17_fam UniProtKB/Swiss-Prot
KEGG Report hsa:64806 UniProtKB/Swiss-Prot
NCBI Gene 64806 ENTREZGENE
OMIM 605658 OMIM
Pfam IL17 UniProtKB/Swiss-Prot
PharmGKB PA29799 PharmGKB
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt IL25_HUMAN UniProtKB/Swiss-Prot
  Q2M3F0 ENTREZGENE
  Q8IZV3 ENTREZGENE
  Q8WXB0 ENTREZGENE
  Q9H293 ENTREZGENE
UniProt Secondary Q2M3F0 UniProtKB/Swiss-Prot
  Q8IZV3 UniProtKB/Swiss-Prot
  Q8WXB0 UniProtKB/Swiss-Prot