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Gene: RSPO4 (R-spondin 4) Homo sapiens
Symbol: RSPO4
Name: R-spondin 4
Description: Predicted to have heparin binding activity. Involved in nail development and positive regulation of Wnt signaling pathway. Predicted to localize to extracellular region. Implicated in nonsyndromic congenital nail disorder 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C20orf182; chromosome 20 open reading frame 182; CRISTIN4; dJ824F16.3; FLJ16018; hRspo4; R-spondin family, member 4; R-spondin-4; roof plate-specific spondin-4
Mus musculus (house mouse) : Rspo4 (R-spondin 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rspo4 (R-spondin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rspo4 (R-spondin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RSPO4 (R-spondin 4)
Canis lupus familiaris (dog) : RSPO4 (R-spondin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rspo4 (R-spondin 4)
Sus scrofa (pig) : RSPO4 (R-spondin 4)
Chlorocebus sabaeus (African green monkey) : RSPO4 (R-spondin 4)
Heterocephalus glaber (naked mole-rat) : Rspo4 (R-spondin 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl20958,452 - 1,002,311 (-)EnsemblGRCh38hg38GRCh38
GRCh3820958,452 - 1,002,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3720939,095 - 982,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3620887,095 - 930,904 (-)NCBINCBI36hg18NCBI36
Celera201,035,254 - 1,079,064 (-)NCBI
Cytogenetic Map20p13NCBI
HuRef20891,402 - 934,970 (-)NCBIHuRef
CHM1_120939,132 - 982,942 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RSPO4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344766
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.