MIR194-2 (microRNA 194-2) - Rat Genome Database
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Gene: MIR194-2 (microRNA 194-2) Homo sapiens
Analyze
Symbol: MIR194-2
Name: microRNA 194-2
RGD ID: 1344358
HGNC Page HGNC
Description: Predicted to be involved in cellular response to amino acid stimulus; cellular response to lipopolysaccharide; and cellular response to mechanical stimulus. Predicted to localize to RISC complex.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-194-2; MIRN194-2
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1164,891,355 - 64,891,439 (-)EnsemblGRCh38hg38GRCh38
GRCh381164,891,355 - 64,891,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,658,827 - 64,658,911 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,415,402 - 64,415,486 (-)NCBINCBI36hg18NCBI36
Celera1161,984,894 - 61,984,978 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,985,859 - 60,985,943 (-)NCBIHuRef
CHM1_11164,542,609 - 64,542,693 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
RISC complex  (ISO)

References
Additional References at PubMed
PMID:12554859   PMID:14573789   PMID:16381832   PMID:17604727   PMID:21037258   PMID:23639576   PMID:23715501   PMID:24398877   PMID:25096247   PMID:25203061   PMID:25602366   PMID:26147452  
PMID:26646931   PMID:26722431   PMID:26731713   PMID:26820911   PMID:26909612   PMID:27480251   PMID:28011622   PMID:28040329   PMID:28358423   PMID:28798470   PMID:28870889   PMID:29131027  
PMID:29518783   PMID:29782828   PMID:30232383   PMID:30278464   PMID:30334578   PMID:30542715   PMID:30720112   PMID:30945295   PMID:31132669   PMID:31301177   PMID:31496625   PMID:31789416  
PMID:31889432   PMID:32228703   PMID:32533463  


Genomics

Comparative Map Data
MIR194-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1164,891,355 - 64,891,439 (-)EnsemblGRCh38hg38GRCh38
GRCh381164,891,355 - 64,891,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,658,827 - 64,658,911 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,415,402 - 64,415,486 (-)NCBINCBI36hg18NCBI36
Celera1161,984,894 - 61,984,978 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,985,859 - 60,985,943 (-)NCBIHuRef
CHM1_11164,542,609 - 64,542,693 (-)NCBICHM1_1
Mir194-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,314,673 - 6,314,758 (+)NCBIGRCm39mm39
GRCm39 Ensembl196,314,673 - 6,314,758 (+)Ensembl
GRCm38196,264,643 - 6,264,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,264,643 - 6,264,728 (+)EnsemblGRCm38mm10GRCm38
MGSCv37196,264,643 - 6,264,728 (+)NCBIGRCm37mm9NCBIm37
Celera196,136,972 - 6,137,057 (+)NCBICelera
Cytogenetic Map19ANCBI
Mir194-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21203,564,761 - 203,564,845 (+)NCBI
Rnor_6.0 Ensembl1221,634,786 - 221,634,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01221,634,786 - 221,634,870 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01228,619,887 - 228,619,971 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1201,098,296 - 201,098,380 (+)NCBICelera
Cytogenetic Map1q43NCBI

Position Markers
ECD00132  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,658,555 - 64,659,487UniSTSGRCh37
Build 361164,415,131 - 64,416,063RGDNCBI36
Celera1161,984,622 - 61,985,554RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,985,587 - 60,986,519UniSTS
ECD23426  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,792 - 64,659,981UniSTSGRCh37
Build 361164,416,368 - 64,416,557RGDNCBI36
Celera1161,985,859 - 61,986,048RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,824 - 60,987,013UniSTS
REN56878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,658,396 - 64,658,645UniSTSGRCh37
Build 361164,414,972 - 64,415,221RGDNCBI36
Celera1161,984,463 - 61,984,712RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,985,428 - 60,985,677UniSTS
REN56879  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,658,622 - 64,658,860UniSTSGRCh37
Build 361164,415,198 - 64,415,436RGDNCBI36
Celera1161,984,689 - 61,984,927RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,985,654 - 60,985,892UniSTS
REN56880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,658,807 - 64,659,042UniSTSGRCh37
Build 361164,415,383 - 64,415,618RGDNCBI36
Celera1161,984,874 - 61,985,109RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,985,839 - 60,986,074UniSTS
REN56881  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,019 - 64,659,268UniSTSGRCh37
Build 361164,415,595 - 64,415,844RGDNCBI36
Celera1161,985,086 - 61,985,335RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,051 - 60,986,300UniSTS
REN56882  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,247 - 64,659,507UniSTSGRCh37
Build 361164,415,823 - 64,416,083RGDNCBI36
Celera1161,985,314 - 61,985,574RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,279 - 60,986,539UniSTS
REN56883  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,484 - 64,659,735UniSTSGRCh37
Build 361164,416,060 - 64,416,311RGDNCBI36
Celera1161,985,551 - 61,985,802RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,516 - 60,986,767UniSTS
REN56884  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,743 - 64,659,968UniSTSGRCh37
Build 361164,416,319 - 64,416,544RGDNCBI36
Celera1161,985,810 - 61,986,035RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,775 - 60,987,000UniSTS
REN56885  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,659,943 - 64,660,204UniSTSGRCh37
Build 361164,416,519 - 64,416,780RGDNCBI36
Celera1161,986,010 - 61,986,271RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,986,975 - 60,987,236UniSTS
REN56886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,660,197 - 64,660,446UniSTSGRCh37
Build 361164,416,773 - 64,417,022RGDNCBI36
Celera1161,986,264 - 61,986,513RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,987,229 - 60,987,478UniSTS
REN56887  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,660,301 - 64,660,551UniSTSGRCh37
Build 361164,416,877 - 64,417,127RGDNCBI36
Celera1161,986,368 - 61,986,618RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,987,333 - 60,987,583UniSTS
REN56888  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371164,660,530 - 64,660,788UniSTSGRCh37
Build 361164,417,106 - 64,417,364RGDNCBI36
Celera1161,986,597 - 61,986,855RGD
Cytogenetic Map11q13.1UniSTS
HuRef1160,987,562 - 60,987,820UniSTS

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ACVR2Bhsa-miR-194-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22431721
EP300hsa-miR-194-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19569050
CDH2hsa-miR-194-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20979124
SOX5hsa-miR-194-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22396742
TLN2hsa-miR-194-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22829924
BMI1hsa-miR-194-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21851624
SRCAPhsa-miR-194-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TLN2hsa-miR-194-5pOncomiRDBexternal_infoNANA22829924
ACVR2Bhsa-miR-194-5pOncomiRDBexternal_infoNANA22431721
THBS1hsa-miR-194-5pOncomiRDBexternal_infoNANA22028325
BMI1hsa-miR-194-5pOncomiRDBexternal_infoNANA21851624
MDM2hsa-miR-194-5pOncomiRDBexternal_infoNANA20951946

Predicted Targets
Summary Value
Count of predictions:43918
Count of gene targets:15462
Count of transcripts:34155
Interacting mature miRNAs:hsa-miR-194-3p, hsa-miR-194-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384864
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1164,891,355 - 64,891,439 (-)Ensembl
RefSeq Acc Id: NR_029829
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381164,891,355 - 64,891,439 (-)NCBI
GRCh371164,658,827 - 64,658,911 (-)RGD
Celera1161,984,894 - 61,984,978 (-)RGD
HuRef1160,985,859 - 60,985,943 (-)ENTREZGENE
CHM1_11164,542,609 - 64,542,693 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 11q13.1(chr11:64485197-64691737)x3 copy number gain See cases [RCV000203413] Chr11:64485197..64691737 [GRCh37]
Chr11:11q13.1
uncertain significance
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
dup(11)(q13.1q13.1) duplication Ependymoma [RCV000785872] Chr11:63533279..65429676 [GRCh37]
Chr11:11q13.1
likely pathogenic
GRCh37/hg19 11q13.1(chr11:64396501-64883447)x3 copy number gain not provided [RCV000848683] Chr11:64396501..64883447 [GRCh37]
Chr11:11q13.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31565 AgrOrtholog
COSMIC MIR194-2 COSMIC
Ensembl Genes ENSG00000284155 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384864 ENTREZGENE
GTEx ENSG00000284155 GTEx
HGNC ID HGNC:31565 ENTREZGENE
Human Proteome Map MIR194-2 Human Proteome Map
miRBase MI0000732 ENTREZGENE
NCBI Gene 406970 ENTREZGENE
OMIM 610941 OMIM
PharmGKB PA164722554 PharmGKB
RNAcentral URS0000065566 RNACentral
  URS000029C2DC RNACentral
  URS0000759DC6 RNACentral