CENPQ (centromere protein Q) - Rat Genome Database

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Gene: CENPQ (centromere protein Q) Homo sapiens
Analyze
Symbol: CENPQ
Name: centromere protein Q
RGD ID: 1344338
HGNC Page HGNC
Description: Involved in metaphase plate congression and positive regulation of protein localization to kinetochore. Located in actin cytoskeleton and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C6orf139; CENP-Q; chromosome 6 open reading frame 139; FLJ10545
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl649,463,370 - 49,493,107 (+)EnsemblGRCh38hg38GRCh38
GRCh38649,463,327 - 49,493,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37649,431,083 - 49,460,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,539,055 - 49,568,779 (+)NCBINCBI36hg18NCBI36
Build 34649,539,054 - 49,568,779NCBI
Celera650,987,302 - 51,017,018 (+)NCBI
Cytogenetic Map6p12.3NCBI
HuRef649,160,017 - 49,190,307 (+)NCBIHuRef
CHM1_1649,434,135 - 49,463,848 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:14574404   PMID:14702039   PMID:15489334   PMID:16622419   PMID:16622420   PMID:19060904   PMID:21454580   PMID:21832049   PMID:21873635   PMID:23028590   PMID:23455924  
PMID:24981860   PMID:25395579   PMID:25670858   PMID:26186194   PMID:26496610   PMID:28514442   PMID:29449217   PMID:30021884   PMID:32296183   PMID:34079125  


Genomics

Comparative Map Data
CENPQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl649,463,370 - 49,493,107 (+)EnsemblGRCh38hg38GRCh38
GRCh38649,463,327 - 49,493,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37649,431,083 - 49,460,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,539,055 - 49,568,779 (+)NCBINCBI36hg18NCBI36
Build 34649,539,054 - 49,568,779NCBI
Celera650,987,302 - 51,017,018 (+)NCBI
Cytogenetic Map6p12.3NCBI
HuRef649,160,017 - 49,190,307 (+)NCBIHuRef
CHM1_1649,434,135 - 49,463,848 (+)NCBICHM1_1
Cenpq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391741,231,700 - 41,247,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl1741,233,942 - 41,245,938 (-)Ensembl
GRCm381740,920,809 - 40,934,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,923,051 - 40,935,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv371741,060,004 - 41,071,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv361740,386,539 - 40,398,035 (-)NCBImm8
Celera1744,336,299 - 44,347,769 (-)NCBICelera
Cytogenetic Map17B2NCBI
Cenpq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2919,957,040 - 19,972,807 (+)NCBImRatBN7.2
Rnor_6.0923,352,271 - 23,368,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0922,211,293 - 22,226,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4915,758,645 - 15,768,747 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1916,091,441 - 16,106,217 (+)NCBI
Celera917,634,682 - 17,649,991 (+)NCBICelera
Cytogenetic Map9q13NCBI
Cenpq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,464,976 - 33,476,609 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,463,041 - 33,480,573 (-)NCBIChiLan1.0ChiLan1.0
CENPQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1650,302,606 - 50,331,096 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,302,606 - 50,331,096 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0649,040,467 - 49,069,115 (+)NCBIMhudiblu_PPA_v0panPan3
CENPQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11217,339,914 - 17,355,921 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1217,340,001 - 17,355,937 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1217,239,470 - 17,256,300 (+)NCBI
ROS_Cfam_1.01217,835,667 - 17,852,592 (+)NCBI
UMICH_Zoey_3.11217,355,499 - 17,372,346 (+)NCBI
UNSW_CanFamBas_1.01217,460,762 - 17,477,607 (+)NCBI
UU_Cfam_GSD_1.01217,590,343 - 17,607,227 (+)NCBI
Cenpq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494652,752,034 - 52,770,888 (+)NCBI
SpeTri2.0NW_00493647611,189,336 - 11,208,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CENPQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,624,832 - 43,643,600 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1743,624,734 - 43,639,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,146,201 - 50,161,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CENPQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,898,962 - 22,922,234 (-)NCBI
ChlSab1.1 Ensembl1722,900,089 - 22,915,378 (-)Ensembl
Vero_WHO_p1.0NW_02366604449,455,607 - 49,478,619 (+)NCBI
Cenpq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247831,825,234 - 1,838,794 (-)NCBI

Position Markers
SHGC-84918  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37649,445,399 - 49,445,706UniSTSGRCh37
Build 36649,553,358 - 49,553,665RGDNCBI36
Celera651,001,605 - 51,001,912RGD
Cytogenetic Map6p12.3UniSTS
HuRef649,174,758 - 49,175,065UniSTS
TNG Radiation Hybrid Map625036.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:213
Interacting mature miRNAs:227
Transcripts:ENST00000335783
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 176 42 106 75 679 79 478 71 419 100 339 323 10 64 141 3
Low 2262 2568 1617 546 912 383 3874 2103 3313 316 1121 1287 165 1 1139 2643 3 2
Below cutoff 1 370 3 3 348 3 4 23 1 2 3 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000335783   ⟹   ENSP00000337289
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl649,463,370 - 49,493,107 (+)Ensembl
RefSeq Acc Id: NM_018132   ⟹   NP_060602
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38649,463,370 - 49,493,107 (+)NCBI
GRCh37649,431,054 - 49,460,820 (+)NCBI
Build 36649,539,055 - 49,568,779 (+)NCBI Archive
Celera650,987,302 - 51,017,018 (+)RGD
HuRef649,160,017 - 49,190,307 (+)ENTREZGENE
CHM1_1649,434,135 - 49,463,848 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005249205   ⟹   XP_005249262
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38649,463,341 - 49,493,107 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514723   ⟹   XP_011513025
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38649,463,327 - 49,493,107 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_060602   ⟸   NM_018132
- UniProtKB: Q7L2Z9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005249262   ⟸   XM_005249205
- Peptide Label: isoform X2
- UniProtKB: Q7L2Z9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011513025   ⟸   XM_011514723
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000337289   ⟸   ENST00000335783

Promoters
RGD ID:7208293
Promoter ID:EPDNEW_H9892
Type:initiation region
Name:CENPQ_1
Description:centromere protein Q
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38649,463,370 - 49,463,430EPDNEW
RGD ID:6804487
Promoter ID:HG_KWN:53790
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000371200,   NM_018132,   OTTHUMT00000040854
Position:
Human AssemblyChrPosition (strand)Source
Build 36649,537,926 - 49,539,062 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_018132.3(CENPQ):c.547A>C (p.Ile183Leu) single nucleotide variant Malignant melanoma [RCV000067395] Chr6:49488421 [GRCh38]
Chr6:49456134 [GRCh37]
Chr6:49564093 [NCBI36]
Chr6:6p12.3
not provided
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1
pathogenic|uncertain significance
GRCh38/hg38 6p12.3(chr6:47191779-51427306)x1 copy number loss See cases [RCV000141689] Chr6:47191779..51427306 [GRCh38]
Chr6:47159515..51292104 [GRCh37]
Chr6:47267474..51400063 [NCBI36]
Chr6:6p12.3
likely pathogenic
GRCh37/hg19 6p12.3(chr6:48682849-49834213)x3 copy number gain See cases [RCV000240085] Chr6:48682849..49834213 [GRCh37]
Chr6:6p12.3
uncertain significance
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320)x1 copy number loss See cases [RCV000446897] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3
pathogenic
GRCh37/hg19 6p12.3(chr6:49430382-49479720)x3 copy number gain See cases [RCV000447425] Chr6:49430382..49479720 [GRCh37]
Chr6:6p12.3
conflicting data from submitters
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p12.3(chr6:49420560-49446434)x3 copy number gain not provided [RCV000745701] Chr6:49420560..49446434 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49420560-49446509)x3 copy number gain not provided [RCV000745702] Chr6:49420560..49446509 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49423876-49445866)x3 copy number gain not provided [RCV000745703] Chr6:49423876..49445866 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49423876-49446509)x3 copy number gain not provided [RCV000745704] Chr6:49423876..49446509 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49425521-49446434)x3 copy number gain not provided [RCV000745705] Chr6:49425521..49446434 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49430319-49446509)x3 copy number gain not provided [RCV000745706] Chr6:49430319..49446509 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49430319-49485266)x3 copy number gain not provided [RCV000745707] Chr6:49430319..49485266 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p12.3(chr6:49430974-49446509)x3 copy number gain not provided [RCV000745708] Chr6:49430974..49446509 [GRCh37]
Chr6:6p12.3
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p12.3(chr6:48617762-49836065)x3 copy number gain not provided [RCV000849078] Chr6:48617762..49836065 [GRCh37]
Chr6:6p12.3
uncertain significance
GRCh37/hg19 6p12.3(chr6:49459881-50024153)x1 copy number loss not provided [RCV001005795] Chr6:49459881..50024153 [GRCh37]
Chr6:6p12.3
uncertain significance
GRCh37/hg19 6p12.3(chr6:48566675-50063411)x1 copy number loss not provided [RCV001258724] Chr6:48566675..50063411 [GRCh37]
Chr6:6p12.3
uncertain significance
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21347 AgrOrtholog
COSMIC CENPQ COSMIC
Ensembl Genes ENSG00000031691 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000337289 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000335783 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000031691 GTEx
HGNC ID HGNC:21347 ENTREZGENE
Human Proteome Map CENPQ Human Proteome Map
InterPro CAD_CENP-Q UniProtKB/Swiss-Prot
KEGG Report hsa:55166 UniProtKB/Swiss-Prot
NCBI Gene 55166 ENTREZGENE
OMIM 611506 OMIM
PANTHER PTHR31345 UniProtKB/Swiss-Prot
Pfam CENP-Q UniProtKB/Swiss-Prot
PharmGKB PA134973276 PharmGKB
UniProt CENPQ_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8KAF1 UniProtKB/Swiss-Prot
  Q6IN61 UniProtKB/Swiss-Prot
  Q9NVS5 UniProtKB/Swiss-Prot