Gene: KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2) Homo sapiens
Symbol: KCNMB2
Name: potassium calcium-activated channel subfamily M regulatory beta subunit 2
Description: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: big potassium channel beta subunit 2; BK channel beta subunit 2; BK channel subunit beta-2; BKbeta2; calcium-activated potassium channel subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2; charybdotoxin receptor subunit beta-2; hbeta2; hbeta3; hCG1646471; k(VCA)beta-2; large conductance calcium-activated potassium channel beta 2 subunit; large-conductance Ca2+-activated K+ channel beta2 subunit; maxi K channel subunit beta-2; MaxiK channel beta 2 subunit; MaxiK channel beta-subunit 2; MGC22431; OTTHUMP00000211869; OTTHUMP00000211870; OTTHUMP00000211871; OTTHUMP00000211872; OTTHUMP00000211874; potassium channel subfamily M regulatory beta subunit 2; potassium large conductance calcium-activated channel, subfamily M, beta member 2; slo-beta-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383178,536,298 - 178,844,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373178,254,086 - 178,562,217 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363179,736,918 - 180,044,911 (+)NCBINCBI36hg18NCBI36
Build 343179,736,925 - 180,044,919NCBI
Celera3176,655,757 - 176,991,073 (+)NCBI
Cytogenetic Map3q26.32NCBI
HuRef3175,660,432 - 175,967,611 (+)NCBIHuRef
CHM1_13178,217,422 - 178,524,675 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNMB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343870
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE