CLDN20 (claudin 20) - Rat Genome Database

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Gene: CLDN20 (claudin 20) Homo sapiens
Analyze
Symbol: CLDN20
Name: claudin 20
RGD ID: 1343820
HGNC Page HGNC:2042
Description: Predicted to enable identical protein binding activity. Predicted to be involved in bicellular tight junction assembly and calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules. Located in several cellular components, including Golgi apparatus; cytosol; and tight junction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: claudin-20; testis secretory sperm-binding protein Li 229n
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386155,264,013 - 155,276,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6155,264,013 - 155,276,548 (+)EnsemblGRCh38hg38GRCh38
GRCh376155,585,147 - 155,597,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366155,626,839 - 155,639,374 (+)NCBINCBI36Build 36hg18NCBI36
Build 346155,677,259 - 155,689,792NCBI
Celera6156,319,443 - 156,331,976 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6153,147,422 - 153,160,302 (+)NCBIHuRef
CHM1_16155,847,762 - 155,860,297 (+)NCBICHM1_1
T2T-CHM13v2.06156,466,034 - 156,478,569 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
bicellular tight junction  (IBA,IEA,ISS)
cytosol  (IDA)
Golgi apparatus  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA)
tight junction  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1124737   PMID:10690502   PMID:11247307   PMID:11283726   PMID:12231346   PMID:12475568   PMID:12477932   PMID:14574404   PMID:15489334   PMID:16836752   PMID:17207965   PMID:17679949  
PMID:18036336   PMID:18480174   PMID:19706201   PMID:21832049   PMID:21873635   PMID:26186194   PMID:30734065   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
CLDN20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386155,264,013 - 155,276,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6155,264,013 - 155,276,548 (+)EnsemblGRCh38hg38GRCh38
GRCh376155,585,147 - 155,597,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366155,626,839 - 155,639,374 (+)NCBINCBI36Build 36hg18NCBI36
Build 346155,677,259 - 155,689,792NCBI
Celera6156,319,443 - 156,331,976 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6153,147,422 - 153,160,302 (+)NCBIHuRef
CHM1_16155,847,762 - 155,860,297 (+)NCBICHM1_1
T2T-CHM13v2.06156,466,034 - 156,478,569 (+)NCBIT2T-CHM13v2.0
Cldn20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39173,582,829 - 3,583,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl173,582,829 - 3,583,484 (+)EnsemblGRCm39 Ensembl
GRCm38173,532,554 - 3,533,213 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl173,532,554 - 3,533,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv37173,532,554 - 3,533,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36173,489,036 - 3,489,695 (+)NCBIMGSCv36mm8
Celera174,067,361 - 4,068,020 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map172.01NCBI
Cldn20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,539,039 - 46,539,698 (+)NCBIGRCr8
mRatBN7.2144,133,769 - 44,134,428 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,133,769 - 44,134,428 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,674,720 - 44,675,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0150,661,954 - 50,662,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,750,218 - 44,750,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0144,443,218 - 44,447,595 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl144,446,765 - 44,447,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,773,397 - 45,777,686 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4138,528,300 - 38,528,959 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera139,767,484 - 39,768,143 (+)NCBICelera
Cytogenetic Map1q11NCBI
Cldn20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554396,923,157 - 6,924,098 (-)NCBIChiLan1.0ChiLan1.0
CLDN20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25175,295,703 - 175,308,733 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16173,187,143 - 173,194,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06153,089,106 - 153,093,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16159,045,062 - 159,057,687 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6159,056,863 - 159,057,522 (+)Ensemblpanpan1.1panPan2
CLDN20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1145,013,689 - 45,020,882 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl145,018,095 - 45,018,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,851,739 - 45,858,033 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0145,198,080 - 45,204,376 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl145,201,449 - 45,202,108 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1145,065,245 - 45,071,541 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0144,936,971 - 44,943,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0145,493,216 - 45,499,511 (+)NCBIUU_Cfam_GSD_1.0
Cldn20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946140,225,114 - 140,226,850 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364897,477,904 - 7,478,563 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364897,477,160 - 7,478,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,617,807 - 11,618,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1111,617,807 - 11,618,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,591,814 - 13,596,741 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11382,840,409 - 82,841,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1382,840,480 - 82,841,139 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604055,215,518 - 55,216,467 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247853,063,991 - 3,064,650 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247853,063,852 - 3,065,040 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CLDN20
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-25.3(chr6:155123107-155645553)x1 copy number loss See cases [RCV000052620] Chr6:155123107..155645553 [GRCh38]
Chr6:155444241..155966687 [GRCh37]
Chr6:155485933..156008379 [NCBI36]
Chr6:6q25.2-25.3		 uncertain significance
NM_001001346.3(CLDN20):c.648G>A (p.Lys216=) single nucleotide variant Malignant melanoma [RCV000067190] Chr6:155276367 [GRCh38]
Chr6:155597501 [GRCh37]
Chr6:155639193 [NCBI36]
Chr6:6q25.3		 not provided
NM_001001346.3(CLDN20):c.649G>A (p.Asp217Asn) single nucleotide variant Malignant melanoma [RCV000067191] Chr6:155276368 [GRCh38]
Chr6:155597502 [GRCh37]
Chr6:155639194 [NCBI36]
Chr6:6q25.3		 not provided
GRCh38/hg38 6q25.2-25.3(chr6:154178964-159020369)x1 copy number loss See cases [RCV000134896] Chr6:154178964..159020369 [GRCh38]
Chr6:154500098..159441401 [GRCh37]
Chr6:154541790..159361389 [NCBI36]
Chr6:6q25.2-25.3		 likely pathogenic
GRCh38/hg38 6q23.3-25.3(chr6:135358150-155455117)x3 copy number gain See cases [RCV000136826] Chr6:135358150..155455117 [GRCh38]
Chr6:135679288..155776251 [GRCh37]
Chr6:135720981..155817943 [NCBI36]
Chr6:6q23.3-25.3		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.1-25.3(chr6:150381239-159553952)x1 copy number loss See cases [RCV000139578] Chr6:150381239..159553952 [GRCh38]
Chr6:150702375..159974984 [GRCh37]
Chr6:150744068..159894974 [NCBI36]
Chr6:6q25.1-25.3		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153647248-158255989)x1 copy number loss See cases [RCV000446757] Chr6:153647248..158255989 [GRCh37]
Chr6:6q25.2-25.3		 pathogenic
GRCh37/hg19 6q25.3(chr6:155525920-159889169)x1 copy number loss See cases [RCV000447692] Chr6:155525920..159889169 [GRCh37]
Chr6:6q25.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:154648703-156904256)x1 copy number loss not provided [RCV000847839] Chr6:154648703..156904256 [GRCh37]
Chr6:6q25.2-25.3		 uncertain significance
GRCh37/hg19 6q24.3-25.3(chr6:148195086-160127254)x3 copy number gain not provided [RCV000846496] Chr6:148195086..160127254 [GRCh37]
Chr6:6q24.3-25.3		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:155426680-158863541)x3 copy number gain not provided [RCV000845753] Chr6:155426680..158863541 [GRCh37]
Chr6:6q25.2-25.3		 uncertain significance
GRCh37/hg19 6q25.2-25.3(chr6:155308263-158394005) copy number loss Corpus callosum, agenesis of [RCV001352651] Chr6:155308263..158394005 [GRCh37]
Chr6:6q25.2-25.3		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153584880-157203309)x1 copy number loss not provided [RCV001834309] Chr6:153584880..157203309 [GRCh37]
Chr6:6q25.2-25.3		 pathogenic
GRCh37/hg19 6q25.2-26(chr6:153207930-164322346) copy number loss not specified [RCV002053640] Chr6:153207930..164322346 [GRCh37]
Chr6:6q25.2-26		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153647248-158255989) copy number loss not specified [RCV002053641] Chr6:153647248..158255989 [GRCh37]
Chr6:6q25.2-25.3		 pathogenic
GRCh37/hg19 6q25.2-25.3(chr6:153180239-156377315) copy number loss not specified [RCV002053639] Chr6:153180239..156377315 [GRCh37]
Chr6:6q25.2-25.3		 uncertain significance
GRCh37/hg19 6q25.3(chr6:155525920-159889169) copy number loss not specified [RCV002053642] Chr6:155525920..159889169 [GRCh37]
Chr6:6q25.3		 pathogenic
NM_001001346.3(CLDN20):c.115A>G (p.Asn39Asp) single nucleotide variant Inborn genetic diseases [RCV002969975] Chr6:155275834 [GRCh38]
Chr6:155596968 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.137A>G (p.Gln46Arg) single nucleotide variant Inborn genetic diseases [RCV002978184] Chr6:155275856 [GRCh38]
Chr6:155596990 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.404C>T (p.Ser135Leu) single nucleotide variant Inborn genetic diseases [RCV002698454] Chr6:155276123 [GRCh38]
Chr6:155597257 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.145G>A (p.Gly49Arg) single nucleotide variant Inborn genetic diseases [RCV002831389] Chr6:155275864 [GRCh38]
Chr6:155596998 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.239C>T (p.Ala80Val) single nucleotide variant Inborn genetic diseases [RCV003188278] Chr6:155275958 [GRCh38]
Chr6:155597092 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.644T>C (p.Leu215Pro) single nucleotide variant Inborn genetic diseases [RCV003259812] Chr6:155276363 [GRCh38]
Chr6:155597497 [GRCh37]
Chr6:6q25.3		 uncertain significance
NM_001001346.3(CLDN20):c.455T>C (p.Val152Ala) single nucleotide variant Inborn genetic diseases [RCV003215866] Chr6:155276174 [GRCh38]
Chr6:155597308 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh38/hg38 6q25.1-25.3(chr6:150905553-158511926)x1 copy number loss Coffin-Siris syndrome 1 [RCV003327723] Chr6:150905553..158511926 [GRCh38]
Chr6:6q25.1-25.3		 pathogenic
NM_001001346.3(CLDN20):c.632C>A (p.Ser211Tyr) single nucleotide variant Inborn genetic diseases [RCV003383928] Chr6:155276351 [GRCh38]
Chr6:155597485 [GRCh37]
Chr6:6q25.3		 uncertain significance
GRCh37/hg19 6q22.31-25.3(chr6:119840686-156623091)x3 copy number gain not specified [RCV003986631] Chr6:119840686..156623091 [GRCh37]
Chr6:6q22.31-25.3		 pathogenic
NC_000006.12:g.(?_150381239)_(159553952_?)del deletion Chromosome 6q24-q25 deletion syndrome [RCV003884000] Chr6:150381239..159553952 [GRCh38]
Chr6:6q25.1-25.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:44
Interacting mature miRNAs:44
Transcripts:ENST00000367165
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH65775  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376155,583,157 - 155,583,306UniSTSGRCh37
Build 366155,624,849 - 155,624,998RGDNCBI36
Celera6156,317,453 - 156,317,602RGD
Cytogenetic Map6q25UniSTS
Cytogenetic Map6q25.1-q25.3UniSTS
HuRef6153,145,432 - 153,145,581UniSTS
GeneMap99-GB4 RH Map6604.11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 17 10 7 7 6
Low 1019 565 968 252 747 122 2474 466 1487 154 956 948 139 360 1440
Below cutoff 1343 2031 662 299 762 269 1763 1572 2046 202 408 566 31 821 1253 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000367165   ⟹   ENSP00000356133
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6155,264,013 - 155,276,548 (+)Ensembl
RefSeq Acc Id: NM_001001346   ⟹   NP_001001346
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386155,264,013 - 155,276,548 (+)NCBI
GRCh376155,585,147 - 155,597,682 (+)RGD
Build 366155,626,839 - 155,639,374 (+)NCBI Archive
Celera6156,319,443 - 156,331,976 (+)RGD
HuRef6153,147,422 - 153,160,302 (+)ENTREZGENE
CHM1_16155,847,762 - 155,860,297 (+)NCBI
T2T-CHM13v2.06156,466,034 - 156,478,569 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001001346 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH20838 (Get FASTA)   NCBI Sequence Viewer  
  AEE61239 (Get FASTA)   NCBI Sequence Viewer  
  EAW47691 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000356133
  ENSP00000356133.3
GenBank Protein P56880 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001001346   ⟸   NM_001001346
- Peptide Label: precursor
- UniProtKB: P56880 (UniProtKB/Swiss-Prot),   A0A140VKA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000356133   ⟸   ENST00000367165

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56880-F1-model_v2 AlphaFold P56880 1-219 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2042 AgrOrtholog
COSMIC CLDN20 COSMIC
Ensembl Genes ENSG00000171217 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367165 ENTREZGENE
  ENST00000367165.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000171217 GTEx
HGNC ID HGNC:2042 ENTREZGENE
Human Proteome Map CLDN20 Human Proteome Map
InterPro Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Claudin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:49861 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 49861 ENTREZGENE
PANTHER CLAUDIN-20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12002 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26568 PharmGKB
PRINTS CLAUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VKA2 ENTREZGENE, UniProtKB/TrEMBL
  CLD20_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE