FBXL21P (F-box and leucine rich repeat protein 21, pseudogene) - Rat Genome Database

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Gene: FBXL21P (F-box and leucine rich repeat protein 21, pseudogene) Homo sapiens
Analyze
Symbol: FBXL21P
Name: F-box and leucine rich repeat protein 21, pseudogene
RGD ID: 1343721
HGNC Page HGNC:13600
Description: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus.
Type: pseudo (Ensembl: transcribed_unitary_pseudogene)
RefSeq Status: REVIEWED
Previously known as: F-box and leucine rich repeat protein 21 (gene/pseudogene); F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 21 (gene/pseudogene); F-box and leucine-rich repeat protein 3 pseudogene; F-box and leucine-rich repeat protein 3B; F-box protein Fbl3b; F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B; Fbl21; FBL3B; FBXL21; FBXL3B; FBXL3P; MGC120237
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,930,297 - 135,941,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,934,368 - 135,941,671 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,265,986 - 135,277,685 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,300,162 - 135,305,266 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,300,161 - 135,305,266NCBI
Celera5131,390,736 - 131,402,098 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,454,477 - 130,465,824 (+)NCBIHuRef
CHM1_15134,698,629 - 134,709,992 (+)NCBICHM1_1
T2T-CHM13v2.05136,452,800 - 136,464,501 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISS,TAS)
nucleus  (IBA,IEA,ISS)
SCF ubiquitin ligase complex  (IBA,ISS)
ubiquitin ligase complex  (NAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10531035   PMID:12477932   PMID:16344560   PMID:18404645   PMID:19028597   PMID:19240061   PMID:20210993   PMID:20237496   PMID:21873635   PMID:24085301   PMID:25225294   PMID:28514442  
PMID:32937135   PMID:33961781   PMID:36574402  


Genomics

Comparative Map Data
FBXL21P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,930,297 - 135,941,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,934,368 - 135,941,671 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,265,986 - 135,277,685 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,300,162 - 135,305,266 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,300,161 - 135,305,266NCBI
Celera5131,390,736 - 131,402,098 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,454,477 - 130,465,824 (+)NCBIHuRef
CHM1_15134,698,629 - 134,709,992 (+)NCBICHM1_1
T2T-CHM13v2.05136,452,800 - 136,464,501 (+)NCBIT2T-CHM13v2.0
Fbxl21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,670,201 - 56,685,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,670,285 - 56,685,711 (+)EnsemblGRCm39 Ensembl
GRCm381356,522,388 - 56,537,898 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,522,472 - 56,537,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,623,869 - 56,639,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,532,130 - 56,547,408 (+)NCBIMGSCv36mm8
Celera1357,585,875 - 57,601,152 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.07NCBI
Fbxl21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,063,731 - 8,082,920 (-)NCBIGRCr8
mRatBN7.2178,060,412 - 8,077,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,060,414 - 8,073,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,079,196 - 8,091,275 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,610,824 - 9,622,813 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,075,596 - 8,087,673 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,505,771 - 8,520,208 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,505,996 - 8,520,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,681,628 - 10,695,804 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,011,345 - 14,022,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,011,848 - 14,025,798 (-)NCBI
Celera178,155,338 - 8,166,953 (-)NCBICelera
Cytogenetic Map17p14NCBI
Fbxl21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540830,997,793 - 31,012,276 (+)NCBIChiLan1.0ChiLan1.0
LOC100972235
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,217,387 - 131,238,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,356,947 - 129,377,713 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,321,680 - 131,342,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,465,586 - 137,482,373 (+)NCBIpanpan1.1PanPan1.1panPan2
FBXL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,846,512 - 23,859,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,594,423 - 22,606,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,662,792 - 24,675,677 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11123,334,198 - 23,365,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,216,105 - 23,228,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,850,183 - 23,878,742 (+)NCBIUU_Cfam_GSD_1.0
LOC101973554
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,006,075 - 124,023,450 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365973,037,282 - 3,045,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12138,097,009 - 138,108,284 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,765,732 - 143,768,951 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXL21P
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,680,722 - 38,692,592 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603439,216,667 - 39,224,884 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxl21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473311,174,526 - 11,186,938 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:783
Count of miRNA genes:547
Interacting mature miRNAs:592
Transcripts:ENST00000297158, ENST00000467490, ENST00000472159, ENST00000475169, ENST00000478939, ENST00000495672, ENST00000498734
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2 9 9 9 5 9 9 32 47 10
Low 88 7 339 132 40 132 191 60 1071 244 740 94 4 1 2
Below cutoff 1328 377 1138 315 247 268 913 839 2080 53 331 777 49 1 380 633 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000297158
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,934,368 - 135,941,671 (+)Ensembl
RefSeq Acc Id: ENST00000467490
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,930,403 - 135,951,591 (+)Ensembl
RefSeq Acc Id: ENST00000472159
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,930,403 - 135,940,871 (+)Ensembl
RefSeq Acc Id: ENST00000475169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,930,336 - 135,936,840 (+)Ensembl
RefSeq Acc Id: ENST00000478939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,936,795 - 135,941,678 (+)Ensembl
RefSeq Acc Id: ENST00000495672
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,930,317 - 135,936,701 (+)Ensembl
RefSeq Acc Id: ENST00000498734
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,941,323 - 135,951,432 (+)Ensembl
RefSeq Acc Id: ENST00000635168
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5135,930,318 - 135,942,746 (+)Ensembl
RefSeq Acc Id: NR_152420
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,930,297 - 135,941,996 (+)NCBI
T2T-CHM13v2.05136,452,800 - 136,464,501 (+)NCBI
Sequence:
RefSeq Acc Id: NR_152421
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385135,930,297 - 135,941,996 (+)NCBI
T2T-CHM13v2.05136,452,800 - 136,464,501 (+)NCBI
Sequence:
Protein Sequences
GenBank Protein AAF04467 (Get FASTA)   NCBI Sequence Viewer  
  AAI06754 (Get FASTA)   NCBI Sequence Viewer  
  EAW62202 (Get FASTA)   NCBI Sequence Viewer  
  EAW62203 (Get FASTA)   NCBI Sequence Viewer  
  Q9UKT6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UKT6-F1-model_v2 AlphaFold Q9UKT6 1-434 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13600 AgrOrtholog
COSMIC FBXL21P COSMIC
Ensembl Genes ENSG00000164616 Ensembl
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000164616 GTEx
HGNC ID HGNC:13600 ENTREZGENE
Human Proteome Map FBXL21P Human Proteome Map
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 26223 ENTREZGENE
OMIM 609087 OMIM
PANTHER ES1 PROTEIN HOMOLOG, MITOCHONDRIAL UniProtKB/Swiss-Prot
  F-BOX DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot
PharmGKB PA28023 PharmGKB
PROSITE FBOX UniProtKB/Swiss-Prot
SMART FBOX UniProtKB/Swiss-Prot
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot
  SSF81383 UniProtKB/Swiss-Prot
UniProt FXL21_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-30 FBXL21P  F-box and leucine rich repeat protein 21, pseudogene  FBXL21  F-box and leucine rich repeat protein 21 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED
2016-06-14 FBXL21  F-box and leucine rich repeat protein 21 (gene/pseudogene)  FBXL21  F-box and leucine-rich repeat protein 21 (gene/pseudogene)  Symbol and/or name change 5135510 APPROVED