OR5M11 (olfactory receptor family 5 subfamily M member 11) - Rat Genome Database

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Gene: OR5M11 (olfactory receptor family 5 subfamily M member 11) Homo sapiens
Analyze
Symbol: OR5M11
Name: olfactory receptor family 5 subfamily M member 11
RGD ID: 1343585
HGNC Page HGNC:15291
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 5M11; olfactory receptor OR11-199 pseudogene; olfactory receptor, family 5, subfamily M, member 11; OR11-199
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,542,340 - 56,543,257 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,542,340 - 56,543,257 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,309,816 - 56,310,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,066,392 - 56,067,309 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,066,391 - 56,067,309NCBI
Celera1153,657,477 - 53,658,394 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,647,038 - 52,647,955 (-)NCBIHuRef
CHM1_11156,176,091 - 56,177,008 (-)NCBICHM1_1
T2T-CHM13v2.01156,480,263 - 56,481,180 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12213199   PMID:12477932   PMID:14983052   PMID:21873635   PMID:33961781  


Genomics

Comparative Map Data
OR5M11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,542,340 - 56,543,257 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,542,340 - 56,543,257 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,309,816 - 56,310,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,066,392 - 56,067,309 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,066,391 - 56,067,309NCBI
Celera1153,657,477 - 53,658,394 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1152,647,038 - 52,647,955 (-)NCBIHuRef
CHM1_11156,176,091 - 56,177,008 (-)NCBICHM1_1
T2T-CHM13v2.01156,480,263 - 56,481,180 (-)NCBIT2T-CHM13v2.0
Or5m11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39285,805,557 - 85,806,617 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl285,804,239 - 85,809,257 (+)EnsemblGRCm39 Ensembl
GRCm38285,975,213 - 85,976,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl285,973,895 - 85,978,913 (+)EnsemblGRCm38mm10GRCm38
MGSCv37285,815,370 - 85,816,430 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36285,776,084 - 85,777,058 (+)NCBIMGSCv36mm8
Celera287,558,826 - 87,559,886 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.69NCBI
Or5m11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8391,424,233 - 91,425,207 (+)NCBIGRCr8
mRatBN7.2371,017,564 - 71,018,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl371,017,564 - 71,018,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx374,402,100 - 74,403,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0383,000,628 - 83,001,602 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0380,783,791 - 80,784,765 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0373,335,149 - 73,336,123 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl373,335,149 - 73,336,123 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0379,903,705 - 79,904,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4369,187,559 - 69,188,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1369,083,930 - 69,084,905 (+)NCBI
Celera370,348,198 - 70,349,172 (+)NCBICelera
Cytogenetic Map3q24NCBI
OR5M13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11839,412,932 - 39,425,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,958,385 - 38,959,320 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01840,093,156 - 40,094,091 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1840,093,168 - 40,094,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11839,695,240 - 39,696,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01839,262,425 - 39,263,360 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,845,153 - 39,846,088 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in OR5M11
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q11-12.1(chr11:55445689-57114783)x1 copy number loss See cases [RCV000050913] Chr11:55445689..57114783 [GRCh38]
Chr11:55213165..56882257 [GRCh37]
Chr11:54969741..56638833 [NCBI36]
Chr11:11q11-12.1		 benign
NM_001005245.1(OR5M11):c.675C>T (p.Leu225=) single nucleotide variant Malignant melanoma [RCV000069493] Chr11:56542583 [GRCh38]
Chr11:56310059 [GRCh37]
Chr11:56066635 [NCBI36]
Chr11:11q12.1		 not provided
NM_001005245.1(OR5M11):c.309C>T (p.Phe103=) single nucleotide variant Malignant melanoma [RCV000069494] Chr11:56542949 [GRCh38]
Chr11:56310425 [GRCh37]
Chr11:56067001 [NCBI36]
Chr11:11q12.1		 not provided
GRCh38/hg38 11q12.1(chr11:56149822-56770518)x3 copy number gain See cases [RCV000134767] Chr11:56149822..56770518 [GRCh38]
Chr11:55917298..56537994 [GRCh37]
Chr11:55673874..56294570 [NCBI36]
Chr11:11q12.1		 benign
GRCh38/hg38 11q11-12.1(chr11:55316535-57539457)x3 copy number gain See cases [RCV000141200] Chr11:55316535..57539457 [GRCh38]
Chr11:55084011..57306930 [GRCh37]
Chr11:54840587..57063506 [NCBI36]
Chr11:11q11-12.1		 uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55319519-58998777)x3 copy number gain See cases [RCV000142757] Chr11:55319519..58998777 [GRCh38]
Chr11:55086995..58766250 [GRCh37]
Chr11:54843571..58522826 [NCBI36]
Chr11:11q11-12.1		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001005245.1(OR5M11):c.161G>A (p.Arg54His) single nucleotide variant Inborn genetic diseases [RCV003297986] Chr11:56543097 [GRCh38]
Chr11:56310573 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q12.1(chr11:51183548-56977098)x3 copy number gain See cases [RCV000512524] Chr11:51183548..56977098 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q12.1(chr11:49313405-59008426)x3 copy number gain not provided [RCV000683370] Chr11:49313405..59008426 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
Single allele duplication not provided [RCV000844966] Chr11:55033164..57518726 [GRCh37]
Chr11:11q11-12.1		 not provided
NM_001005245.1(OR5M11):c.705G>T (p.Lys235Asn) single nucleotide variant Inborn genetic diseases [RCV003240403] Chr11:56542553 [GRCh38]
Chr11:56310029 [GRCh37]
Chr11:11q12.1		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p11.12-q12.1(chr11:51164494-56879839)x3 copy number gain not provided [RCV001827812] Chr11:51164494..56879839 [GRCh37]
Chr11:11p11.12-q12.1		 uncertain significance
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
NM_001005245.1(OR5M11):c.716C>G (p.Thr239Ser) single nucleotide variant Inborn genetic diseases [RCV003261662] Chr11:56542542 [GRCh38]
Chr11:56310018 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.722G>A (p.Gly241Asp) single nucleotide variant Inborn genetic diseases [RCV002870281] Chr11:56542536 [GRCh38]
Chr11:56310012 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.133A>G (p.Met45Val) single nucleotide variant Inborn genetic diseases [RCV002951535] Chr11:56543125 [GRCh38]
Chr11:56310601 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.623G>A (p.Ser208Asn) single nucleotide variant Inborn genetic diseases [RCV002821746] Chr11:56542635 [GRCh38]
Chr11:56310111 [GRCh37]
Chr11:11q12.1		 likely benign
NM_001005245.1(OR5M11):c.545C>T (p.Pro182Leu) single nucleotide variant Inborn genetic diseases [RCV002709333] Chr11:56542713 [GRCh38]
Chr11:56310189 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.62C>T (p.Pro21Leu) single nucleotide variant Inborn genetic diseases [RCV002897577] Chr11:56543196 [GRCh38]
Chr11:56310672 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.745C>G (p.Leu249Val) single nucleotide variant Inborn genetic diseases [RCV002678084] Chr11:56542513 [GRCh38]
Chr11:56309989 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.461A>G (p.Asp154Gly) single nucleotide variant Inborn genetic diseases [RCV003278226] Chr11:56542797 [GRCh38]
Chr11:56310273 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.472C>A (p.Gln158Lys) single nucleotide variant Inborn genetic diseases [RCV003204916] Chr11:56542786 [GRCh38]
Chr11:56310262 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.109G>A (p.Val37Ile) single nucleotide variant Inborn genetic diseases [RCV003209285] Chr11:56543149 [GRCh38]
Chr11:56310625 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11q12.1(chr11:56294818-56645710)x1 copy number loss not provided [RCV000737534] Chr11:56294818..56645710 [GRCh37]
Chr11:11q12.1		 benign
NM_001005245.1(OR5M11):c.423C>G (p.Ile141Met) single nucleotide variant Inborn genetic diseases [RCV003218739] Chr11:56542835 [GRCh38]
Chr11:56310311 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_001005245.1(OR5M11):c.629T>C (p.Leu210Pro) single nucleotide variant Inborn genetic diseases [RCV003375988] Chr11:56542629 [GRCh38]
Chr11:56310105 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:68
Interacting mature miRNAs:68
Transcripts:ENST00000528616
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 6 1 1 1 3 1 2 11 79 15 1
Below cutoff 198 60 51 26 83 16 471 70 63 49 323 82 11 31 286

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000528616   ⟹   ENSP00000432417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,542,340 - 56,543,257 (-)Ensembl
RefSeq Acc Id: NM_001005245   ⟹   NP_001005245
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,542,340 - 56,543,257 (-)NCBI
GRCh371156,309,816 - 56,310,733 (-)RGD
Build 361156,066,392 - 56,067,309 (-)NCBI Archive
Celera1153,657,477 - 53,658,394 (-)RGD
HuRef1152,647,038 - 52,647,955 (-)RGD
CHM1_11156,176,091 - 56,177,008 (-)NCBI
T2T-CHM13v2.01156,480,263 - 56,481,180 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001005245 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI36952 (Get FASTA)   NCBI Sequence Viewer  
  AAI36954 (Get FASTA)   NCBI Sequence Viewer  
  AAK95006 (Get FASTA)   NCBI Sequence Viewer  
  ALI87481 (Get FASTA)   NCBI Sequence Viewer  
  EAW73717 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000432417
  ENSP00000432417.2
GenBank Protein Q96RB7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001005245   ⟸   NM_001005245
- UniProtKB: B2RNL5 (UniProtKB/Swiss-Prot),   B2RNL7 (UniProtKB/Swiss-Prot),   Q96RB7 (UniProtKB/Swiss-Prot),   A0A126GVL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000432417   ⟸   ENST00000528616
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96RB7-F1-model_v2 AlphaFold Q96RB7 1-305 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15291 AgrOrtholog
COSMIC OR5M11 COSMIC
Ensembl Genes ENSG00000255223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000528616 ENTREZGENE
  ENST00000528616.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000255223 GTEx
HGNC ID HGNC:15291 ENTREZGENE
Human Proteome Map OR5M11 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:219487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 219487 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 5M11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32548 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A126GVL9 ENTREZGENE, UniProtKB/TrEMBL
  B2RNL5 ENTREZGENE
  B2RNL7 ENTREZGENE
  OR5MB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RNL5 UniProtKB/Swiss-Prot
  B2RNL7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 OR5M11  olfactory receptor family 5 subfamily M member 11  OR5M11  olfactory receptor, family 5, subfamily M, member 11  Symbol and/or name change 5135510 APPROVED