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Gene: TGM3 (transglutaminase 3) Homo sapiens
Symbol: TGM3
Name: transglutaminase 3
Description: Exhibits calcium ion binding activity; protein-glutamine gamma-glutamyltransferase activity; and structural molecule activity. Involved in cell envelope organization; keratinocyte differentiation; and peptide cross-linking. Localizes to cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E polypeptide, protein-glutamine-gamma-glutamyltransferase; MGC126249; MGC126250; protein-glutamine gamma-glutamyltransferase E; TG(E); TGase E; TGase-3; TGE; transglutaminase E; transglutaminase-3; UHS2
Mus musculus (house mouse) : Tgm3 (transglutaminase 3, E polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgm3 (transglutaminase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgm3 (transglutaminase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TGM3 (transglutaminase 3)
Canis lupus familiaris (dog) : TGM3 (transglutaminase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgm3 (transglutaminase 3)
Sus scrofa (pig) : TGM3 (transglutaminase 3)
Chlorocebus sabaeus (African green monkey) : TGM3 (transglutaminase 3)
Heterocephalus glaber (naked mole-rat) : Tgm3 (transglutaminase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl202,296,001 - 2,341,079 (+)EnsemblGRCh38hg38GRCh38
GRCh38202,296,001 - 2,341,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37202,276,613 - 2,321,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,224,675 - 2,269,725 (+)NCBINCBI36hg18NCBI36
Build 34202,224,674 - 2,269,725NCBI
Celera202,341,537 - 2,386,652 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef202,226,325 - 2,271,443 (+)NCBIHuRef
CHM1_1202,276,742 - 2,321,867 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TGM3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343492
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.