MAPRE3 (microtubule associated protein RP/EB family member 3) - Rat Genome Database

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Gene: MAPRE3 (microtubule associated protein RP/EB family member 3) Homo sapiens
Analyze
Symbol: MAPRE3
Name: microtubule associated protein RP/EB family member 3
RGD ID: 1343455
HGNC Page HGNC:6892
Description: Enables identical protein binding activity and protein kinase binding activity. Involved in regulation of microtubule polymerization. Located in mitotic spindle astral microtubule end and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: APC binding protein; EB1 protein family member 3; EB3; EBF3; EBF3-S; end-binding protein 3; microtubule-associated protein RP/EB family member 3; microtubule-associated protein, RP/EB family, member 3; RP3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,970,637 - 27,027,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,970,637 - 27,027,219 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,193,505 - 27,250,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,047,029 - 27,103,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,105,175 - 27,161,737NCBI
Celera227,039,865 - 27,096,433 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,935,669 - 26,992,235 (+)NCBIHuRef
CHM1_1227,123,437 - 27,179,999 (+)NCBICHM1_1
T2T-CHM13v2.0227,012,305 - 27,068,902 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9233623   PMID:10188731   PMID:10644998   PMID:11161807   PMID:12477932   PMID:14514668   PMID:15117959   PMID:15489334   PMID:15631994   PMID:16079286   PMID:16169070   PMID:16189514  
PMID:17310996   PMID:18029348   PMID:19146815   PMID:19255245   PMID:19696028   PMID:20008324   PMID:20195357   PMID:20632835   PMID:21516116   PMID:21768326   PMID:21873635   PMID:22275434  
PMID:23001180   PMID:23159740   PMID:23456299   PMID:23509069   PMID:23572079   PMID:23712260   PMID:24040250   PMID:24478452   PMID:25416956   PMID:25814554   PMID:26186194   PMID:26264872  
PMID:26323690   PMID:26344197   PMID:26638075   PMID:27107012   PMID:27107014   PMID:27173435   PMID:28319065   PMID:28514442   PMID:28814570   PMID:28865014   PMID:29089450   PMID:29162697  
PMID:29743530   PMID:29997244   PMID:30217970   PMID:30466786   PMID:30668577   PMID:31515488   PMID:31542321   PMID:32129710   PMID:32296183   PMID:32421702   PMID:32814053   PMID:33961781  
PMID:34079125   PMID:35271311   PMID:35831314   PMID:36215168   PMID:38199479  


Genomics

Comparative Map Data
MAPRE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,970,637 - 27,027,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,970,637 - 27,027,219 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,193,505 - 27,250,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,047,029 - 27,103,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,105,175 - 27,161,737NCBI
Celera227,039,865 - 27,096,433 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,935,669 - 26,992,235 (+)NCBIHuRef
CHM1_1227,123,437 - 27,179,999 (+)NCBICHM1_1
T2T-CHM13v2.0227,012,305 - 27,068,902 (+)NCBIT2T-CHM13v2.0
Mapre3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,972,075 - 31,023,447 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,971,985 - 31,023,450 (+)EnsemblGRCm39 Ensembl
GRCm38530,814,606 - 30,866,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,814,641 - 30,866,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,117,129 - 31,168,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,091,337 - 31,142,687 (+)NCBIMGSCv36mm8
Celera528,293,934 - 28,345,490 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Mapre3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,233,736 - 31,278,626 (-)NCBIGRCr8
mRatBN7.2625,513,800 - 25,558,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,513,800 - 25,558,881 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,814,084 - 25,825,198 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,129,947 - 26,141,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,609,146 - 25,620,313 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,878,738 - 26,923,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,878,744 - 26,889,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,695,659 - 36,739,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,496,282 - 25,506,449 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,499,234 - 25,509,402 (-)NCBI
Celera625,004,257 - 25,015,289 (-)NCBICelera
Cytogenetic Map6q14NCBI
Mapre3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,000,940 - 9,005,454 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,947,324 - 9,005,401 (+)NCBIChiLan1.0ChiLan1.0
MAPRE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,488,346 - 99,544,668 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,492,313 - 99,548,635 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,970,010 - 27,026,223 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,059,002 - 27,115,223 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,102,780 - 27,115,223 (+)Ensemblpanpan1.1panPan2
MAPRE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,971,868 - 21,027,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,015,464 - 21,026,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,864,475 - 20,920,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,292,052 - 21,347,806 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,291,904 - 21,349,898 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,980,681 - 21,034,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,991,765 - 21,046,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,038,213 - 21,092,479 (+)NCBIUU_Cfam_GSD_1.0
Mapre3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,302,728 - 65,321,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,518,116 - 5,536,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,518,124 - 5,522,760 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPRE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,084,469 - 112,136,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,084,467 - 112,136,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,083,232 - 119,135,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPRE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,598,660 - 80,610,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,598,029 - 80,656,243 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,483,308 - 31,541,490 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapre3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,131,768 - 9,136,080 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,063,795 - 9,136,080 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPRE3
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1		 pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p23.3(chr2:25759602-27297636)x3 copy number gain See cases [RCV000052629] Chr2:25759602..27297636 [GRCh38]
Chr2:25982471..27520504 [GRCh37]
Chr2:25835975..27374008 [NCBI36]
Chr2:2p23.3		 uncertain significance
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2		 pathogenic
GRCh38/hg38 2p23.3(chr2:25064306-27154398)x1 copy number loss See cases [RCV000137065] Chr2:25064306..27154398 [GRCh38]
Chr2:25287175..27377266 [GRCh37]
Chr2:25140679..27230770 [NCBI36]
Chr2:2p23.3		 uncertain significance
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3		 pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p24.1-23.2(chr2:22579652-28525186)x1 copy number loss See cases [RCV000142071] Chr2:22579652..28525186 [GRCh38]
Chr2:22802524..28748053 [GRCh37]
Chr2:22656029..28601557 [NCBI36]
Chr2:2p24.1-23.2		 pathogenic
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p23.3(chr2:26592685-27262646)x3 copy number gain See cases [RCV000448086] Chr2:26592685..27262646 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_012326.4(MAPRE3):c.569C>T (p.Ser190Leu) single nucleotide variant Inborn genetic diseases [RCV003287802] Chr2:27025682 [GRCh38]
Chr2:27248550 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p24.1-16.3(chr2:22665048-52850368)x3 copy number gain not provided [RCV000752875] Chr2:22665048..52850368 [GRCh37]
Chr2:2p24.1-16.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p23.3-21(chr2:24881528-43460021)x3 copy number gain not provided [RCV001532444] Chr2:24881528..43460021 [GRCh37]
Chr2:2p23.3-21		 likely pathogenic
GRCh37/hg19 2p23.3-21(chr2:24601818-43466284)x3 copy number gain See cases [RCV001581099] Chr2:24601818..43466284 [GRCh37]
Chr2:2p23.3-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p23.3(chr2:26860458-27346266)x1 copy number loss Ritscher-Schinzel syndrome 4 [RCV001801216] Chr2:26860458..27346266 [GRCh37]
Chr2:2p23.3		 uncertain significance
GRCh37/hg19 2p23.3(chr2:26592685-27262646) copy number gain not specified [RCV002053078] Chr2:26592685..27262646 [GRCh37]
Chr2:2p23.3		 uncertain significance
NC_000002.11:g.(?_24443763)_(27746306_?)dup duplication Short-rib thoracic dysplasia 10 with or without polydactyly [RCV001911738] Chr2:24443763..27746306 [GRCh37]
Chr2:2p23.3		 uncertain significance
NC_000002.11:g.(?_24443763)_(29022169_?)dup duplication Tatton-Brown-Rahman overgrowth syndrome [RCV003113871]|not provided [RCV003113870] Chr2:24443763..29022169 [GRCh37]
Chr2:2p23.3-23.2		 uncertain significance|no classifications from unflagged records
NC_000002.11:g.(?_24443763)_(30143525_?)dup duplication not provided [RCV003113441] Chr2:24443763..30143525 [GRCh37]
Chr2:2p23.3-23.1		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
GRCh37/hg19 2p25.3-22.3(chr2:706460-35523639)x3 copy number gain not provided [RCV002473946] Chr2:706460..35523639 [GRCh37]
Chr2:2p25.3-22.3		 pathogenic
NM_012326.4(MAPRE3):c.460G>A (p.Gly154Ser) single nucleotide variant Inborn genetic diseases [RCV002818524] Chr2:27024288 [GRCh38]
Chr2:27247156 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_012326.4(MAPRE3):c.814G>C (p.Glu272Gln) single nucleotide variant Inborn genetic diseases [RCV002977087] Chr2:27026316 [GRCh38]
Chr2:27249184 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_012326.4(MAPRE3):c.610G>A (p.Glu204Lys) single nucleotide variant Inborn genetic diseases [RCV002891865] Chr2:27025723 [GRCh38]
Chr2:27248591 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_012326.4(MAPRE3):c.632A>T (p.Asp211Val) single nucleotide variant Inborn genetic diseases [RCV003280605] Chr2:27025887 [GRCh38]
Chr2:27248755 [GRCh37]
Chr2:2p23.3		 uncertain significance
NM_012326.4(MAPRE3):c.407C>T (p.Ala136Val) single nucleotide variant Inborn genetic diseases [RCV003176003] Chr2:27024235 [GRCh38]
Chr2:27247103 [GRCh37]
Chr2:2p23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3133
Count of miRNA genes:953
Interacting mature miRNAs:1168
Transcripts:ENST00000233121, ENST00000402218, ENST00000405074, ENST00000458529, ENST00000474367, ENST00000475633, ENST00000481222, ENST00000491354, ENST00000494788
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98551  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37227,249,821 - 27,249,972UniSTSGRCh37
Build 36227,103,325 - 27,103,476RGDNCBI36
Celera227,096,167 - 27,096,318RGD
Cytogenetic Map2p23.3-p23.1UniSTS
HuRef226,991,969 - 26,992,120UniSTS
GeneMap99-GB4 RH Map293.05UniSTS
RH102194  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37227,249,476 - 27,249,623UniSTSGRCh37
Build 36227,102,980 - 27,103,127RGDNCBI36
Celera227,095,822 - 27,095,969RGD
Cytogenetic Map2p23.3-p23.1UniSTS
HuRef226,991,624 - 26,991,771UniSTS
GeneMap99-GB4 RH Map297.69UniSTS
D2S1562E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37227,245,164 - 27,246,272UniSTSGRCh37
Build 36227,098,668 - 27,099,776RGDNCBI36
Celera227,091,510 - 27,092,618RGD
Cytogenetic Map2p23.3-p23.1UniSTS
HuRef226,987,312 - 26,988,420UniSTS
SHGC-143589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37227,206,260 - 27,206,587UniSTSGRCh37
Build 36227,059,764 - 27,060,091RGDNCBI36
Celera227,052,599 - 27,052,926RGD
Cytogenetic Map2p23.3-p23.1UniSTS
HuRef226,948,403 - 26,948,730UniSTS
TNG Radiation Hybrid Map219691.0UniSTS
RH12421  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37227,248,812 - 27,249,179UniSTSGRCh37
Build 36227,102,316 - 27,102,683RGDNCBI36
Celera227,095,158 - 27,095,525RGD
Cytogenetic Map2p23.3-p23.1UniSTS
HuRef226,990,960 - 26,991,327UniSTS
GeneMap99-GB4 RH Map297.69UniSTS
NCBI RH Map2166.8UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2262 2222 1596 515 461 360 4139 2086 3690 335 1335 1545 169 1204 2785 1
Low 170 758 124 107 1403 104 216 108 41 83 115 65 3 3 3
Below cutoff 3 7 5 56 1 2 3 1 8 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001303050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047443728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC013472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM560331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC417465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY011071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000233121   ⟹   ENSP00000233121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,970,637 - 27,027,219 (+)Ensembl
RefSeq Acc Id: ENST00000402218   ⟹   ENSP00000385715
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,014,799 - 27,026,355 (+)Ensembl
RefSeq Acc Id: ENST00000405074   ⟹   ENSP00000383915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,970,658 - 27,027,196 (+)Ensembl
RefSeq Acc Id: ENST00000458529   ⟹   ENSP00000391705
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,014,768 - 27,025,909 (+)Ensembl
RefSeq Acc Id: ENST00000474367
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,014,765 - 27,023,534 (+)Ensembl
RefSeq Acc Id: ENST00000475633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,970,661 - 27,024,221 (+)Ensembl
RefSeq Acc Id: ENST00000481222
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,002,046 - 27,023,945 (+)Ensembl
RefSeq Acc Id: ENST00000491354
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,002,856 - 27,022,851 (+)Ensembl
RefSeq Acc Id: ENST00000494788
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl226,970,637 - 27,022,619 (+)Ensembl
RefSeq Acc Id: ENST00000648289   ⟹   ENSP00000497057
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl227,014,754 - 27,026,430 (+)Ensembl
RefSeq Acc Id: NM_001303050   ⟹   NP_001289979
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38227,014,754 - 27,027,219 (+)NCBI
CHM1_1227,167,532 - 27,179,999 (+)NCBI
T2T-CHM13v2.0227,056,435 - 27,068,902 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001410716   ⟹   NP_001397645
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38226,970,637 - 27,027,219 (+)NCBI
T2T-CHM13v2.0227,012,305 - 27,068,902 (+)NCBI
RefSeq Acc Id: NM_012326   ⟹   NP_036458
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38226,970,637 - 27,027,219 (+)NCBI
GRCh37227,193,525 - 27,250,087 (+)ENTREZGENE
Build 36227,047,029 - 27,103,591 (+)NCBI Archive
HuRef226,935,669 - 26,992,235 (+)ENTREZGENE
CHM1_1227,123,151 - 27,179,999 (+)NCBI
T2T-CHM13v2.0227,012,305 - 27,068,902 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047443728   ⟹   XP_047299684
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38227,014,754 - 27,027,219 (+)NCBI
RefSeq Acc Id: XM_054341040   ⟹   XP_054197015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0227,056,501 - 27,068,902 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036458   ⟸   NM_012326
- Peptide Label: isoform 1
- UniProtKB: Q9BZP7 (UniProtKB/Swiss-Prot),   Q6FI15 (UniProtKB/Swiss-Prot),   Q6FHB0 (UniProtKB/Swiss-Prot),   O00265 (UniProtKB/Swiss-Prot),   B7WPK5 (UniProtKB/Swiss-Prot),   Q9BZP8 (UniProtKB/Swiss-Prot),   Q9UPY8 (UniProtKB/Swiss-Prot),   B2R5W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289979   ⟸   NM_001303050
- Peptide Label: isoform 1
- UniProtKB: Q9BZP7 (UniProtKB/Swiss-Prot),   Q6FI15 (UniProtKB/Swiss-Prot),   Q6FHB0 (UniProtKB/Swiss-Prot),   O00265 (UniProtKB/Swiss-Prot),   B7WPK5 (UniProtKB/Swiss-Prot),   Q9BZP8 (UniProtKB/Swiss-Prot),   Q9UPY8 (UniProtKB/Swiss-Prot),   B2R5W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000497057   ⟸   ENST00000648289
RefSeq Acc Id: ENSP00000385715   ⟸   ENST00000402218
RefSeq Acc Id: ENSP00000233121   ⟸   ENST00000233121
RefSeq Acc Id: ENSP00000391705   ⟸   ENST00000458529
RefSeq Acc Id: ENSP00000383915   ⟸   ENST00000405074
RefSeq Acc Id: XP_047299684   ⟸   XM_047443728
- Peptide Label: isoform X1
- UniProtKB: Q9UPY8 (UniProtKB/Swiss-Prot),   Q9BZP7 (UniProtKB/Swiss-Prot),   Q6FI15 (UniProtKB/Swiss-Prot),   Q6FHB0 (UniProtKB/Swiss-Prot),   O00265 (UniProtKB/Swiss-Prot),   B7WPK5 (UniProtKB/Swiss-Prot),   Q9BZP8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001397645   ⟸   NM_001410716
- Peptide Label: isoform 2
RefSeq Acc Id: XP_054197015   ⟸   XM_054341040
- Peptide Label: isoform X1
- UniProtKB: Q9BZP8 (UniProtKB/Swiss-Prot),   Q9UPY8 (UniProtKB/Swiss-Prot),   Q9BZP7 (UniProtKB/Swiss-Prot),   Q6FI15 (UniProtKB/Swiss-Prot),   Q6FHB0 (UniProtKB/Swiss-Prot),   O00265 (UniProtKB/Swiss-Prot),   B7WPK5 (UniProtKB/Swiss-Prot)
Protein Domains
Calponin-homology (CH)   EB1 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UPY8-F1-model_v2 AlphaFold Q9UPY8 1-281 view protein structure

Promoters
RGD ID:6859864
Promoter ID:EPDNEW_H3097
Type:initiation region
Name:MAPRE3_1
Description:microtubule associated protein RP/EB family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3098  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38226,970,637 - 26,970,697EPDNEW
RGD ID:6859866
Promoter ID:EPDNEW_H3098
Type:multiple initiation site
Name:MAPRE3_2
Description:microtubule associated protein RP/EB family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3097  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38227,014,754 - 27,014,814EPDNEW
RGD ID:6797774
Promoter ID:HG_KWN:31883
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562
Transcripts:OTTHUMT00000214183,   OTTHUMT00000324728,   OTTHUMT00000324729,   UC002RHX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36227,046,671 - 27,047,171 (+)MPROMDB
RGD ID:6797816
Promoter ID:HG_KWN:31888
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000380387,   ENST00000402218,   OTTHUMT00000324725,   OTTHUMT00000324727,   OTTHUMT00000324744,   OTTHUMT00000324745,   OTTHUMT00000324746
Position:
Human AssemblyChrPosition (strand)Source
Build 36227,091,476 - 27,091,976 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6892 AgrOrtholog
COSMIC MAPRE3 COSMIC
Ensembl Genes ENSG00000084764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000233121 ENTREZGENE
  ENST00000233121.7 UniProtKB/Swiss-Prot
  ENST00000402218.1 UniProtKB/Swiss-Prot
  ENST00000405074 ENTREZGENE
  ENST00000405074.7 UniProtKB/Swiss-Prot
  ENST00000458529.5 UniProtKB/TrEMBL
  ENST00000648289.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.1430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000084764 GTEx
HGNC ID HGNC:6892 ENTREZGENE
Human Proteome Map MAPRE3 Human Proteome Map
InterPro CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EB1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EB1_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPRE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:22924 UniProtKB/Swiss-Prot
NCBI Gene 22924 ENTREZGENE
OMIM 605788 OMIM
PANTHER PTHR10623 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10623:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30636 PharmGKB
PROSITE EB1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EB1 dimerisation domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R5W6 ENTREZGENE, UniProtKB/TrEMBL
  B7WPK5 ENTREZGENE
  C9JB30_HUMAN UniProtKB/TrEMBL
  MARE3_HUMAN UniProtKB/Swiss-Prot
  O00265 ENTREZGENE
  Q6FHB0 ENTREZGENE
  Q6FI15 ENTREZGENE
  Q9BZP7 ENTREZGENE
  Q9BZP8 ENTREZGENE
  Q9UPY8 ENTREZGENE
UniProt Secondary B7WPK5 UniProtKB/Swiss-Prot
  O00265 UniProtKB/Swiss-Prot
  Q6FHB0 UniProtKB/Swiss-Prot
  Q6FI15 UniProtKB/Swiss-Prot
  Q9BZP7 UniProtKB/Swiss-Prot
  Q9BZP8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 MAPRE3  microtubule associated protein RP/EB family member 3    microtubule-associated protein, RP/EB family, member 3  Symbol and/or name change 5135510 APPROVED