GAL3ST3 (galactose-3-O-sulfotransferase 3) - Rat Genome Database

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Gene: GAL3ST3 (galactose-3-O-sulfotransferase 3) Homo sapiens
Analyze
Symbol: GAL3ST3
Name: galactose-3-O-sulfotransferase 3
RGD ID: 1343263
HGNC Page HGNC
Description: Exhibits galactose 3-O-sulfotransferase activity. Predicted to be involved in glycolipid biosynthetic process. Predicted to localize to Golgi cisterna membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-galactose-3-O-sulfotransferase 3; gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; GAL3ST-3; GAL3ST2; galactose 3'-sulfotransferase; galbeta1-3GalNAc 3'-sulfotransferase 3; MGC142112; MGC142114
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,040,765 - 66,049,161 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,040,765 - 66,049,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,808,236 - 65,816,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,564,812 - 65,573,227 (-)NCBINCBI36hg18NCBI36
Build 341165,566,028 - 65,573,227NCBI
Celera1163,132,938 - 63,141,353 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1162,134,133 - 62,142,548 (-)NCBIHuRef
CHM1_11165,692,368 - 65,700,783 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10815989   PMID:11323440   PMID:11333265   PMID:11356829   PMID:12477932   PMID:14701868   PMID:15489334   PMID:21873635   PMID:21926972   PMID:24927181   PMID:32296183  


Genomics

Comparative Map Data
GAL3ST3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,040,765 - 66,049,161 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,040,765 - 66,049,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,808,236 - 65,816,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,564,812 - 65,573,227 (-)NCBINCBI36hg18NCBI36
Build 341165,566,028 - 65,573,227NCBI
Celera1163,132,938 - 63,141,353 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1162,134,133 - 62,142,548 (-)NCBIHuRef
CHM1_11165,692,368 - 65,700,783 (-)NCBICHM1_1
Gal3st3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,348,359 - 5,358,767 (+)NCBIGRCm39mm39
GRCm39 Ensembl195,348,359 - 5,358,766 (+)Ensembl
GRCm38195,298,331 - 5,308,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,298,331 - 5,308,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,298,331 - 5,308,739 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,298,341 - 5,308,739 (+)NCBImm8
Celera195,167,423 - 5,177,824 (+)NCBICelera
Cytogenetic Map19ANCBI
Gal3st3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,593,692 - 202,603,446 (+)NCBI
Rnor_6.0 Ensembl1220,668,544 - 220,678,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01220,668,544 - 220,678,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,598,280 - 227,608,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,928,648 - 207,938,404 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1200,132,469 - 200,142,225 (+)NCBICelera
Cytogenetic Map1q43NCBI
Gal3st3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,263,468 - 19,267,029 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,259,551 - 19,267,600 (+)NCBIChiLan1.0ChiLan1.0
GAL3ST3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,732,001 - 64,740,512 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01161,406,398 - 61,413,733 (-)NCBIMhudiblu_PPA_v0panPan3
GAL3ST3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,215,280 - 51,222,962 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,219,156 - 51,222,418 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,823,836 - 49,831,505 (+)NCBI
ROS_Cfam_1.01852,253,675 - 52,261,345 (+)NCBI
UMICH_Zoey_3.11851,353,667 - 51,361,341 (+)NCBI
UNSW_CanFamBas_1.01850,927,905 - 50,935,576 (+)NCBI
UU_Cfam_GSD_1.01851,717,891 - 51,725,566 (+)NCBI
Gal3st3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,055,656 - 7,070,201 (+)NCBI
SpeTri2.0NW_0049365993,498,011 - 3,512,550 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAL3ST3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,297,855 - 6,306,198 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,297,797 - 6,306,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,369,781 - 5,378,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAL3ST3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,210,003 - 8,217,503 (+)NCBI
ChlSab1.1 Ensembl18,214,007 - 8,217,477 (+)Ensembl
Vero_WHO_p1.0NW_023666038105,489,977 - 105,499,172 (+)NCBI
Gal3st3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476720,342,925 - 20,350,892 (+)NCBI

Position Markers
D11S4064  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,808,305 - 65,808,379UniSTSGRCh37
Build 361165,564,881 - 65,564,955RGDNCBI36
Celera1163,133,007 - 63,133,081RGD
Cytogenetic Map11q13.1UniSTS
HuRef1162,134,202 - 62,134,276UniSTS
D11S4418  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,808,280 - 65,808,504UniSTSGRCh37
Build 361165,564,856 - 65,565,080RGDNCBI36
Celera1163,132,982 - 63,133,206RGD
Cytogenetic Map11q13.1UniSTS
HuRef1162,134,177 - 62,134,401UniSTS
GeneMap99-GB4 RH Map11247.67UniSTS
Whitehead-RH Map11336.2UniSTS
NCBI RH Map11573.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:984
Count of miRNA genes:525
Interacting mature miRNAs:584
Transcripts:ENST00000312006, ENST00000527048, ENST00000527878
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1 56 759 2 6 2 181 12 1173 29 87 693 1
Low 669 1597 243 7 26 6 582 981 1910 164 866 74 5 1 67 542 1
Below cutoff 1362 1122 387 285 1155 172 3185 1080 592 101 369 561 119 921 2107

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000312006   ⟹   ENSP00000308591
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1166,040,765 - 66,049,161 (-)Ensembl
RefSeq Acc Id: ENST00000527048
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1166,044,991 - 66,049,151 (-)Ensembl
RefSeq Acc Id: ENST00000527878   ⟹   ENSP00000434829
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1166,042,364 - 66,045,575 (-)Ensembl
RefSeq Acc Id: NM_033036   ⟹   NP_149025
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381166,040,765 - 66,049,161 (-)NCBI
GRCh371165,808,236 - 65,816,651 (-)RGD
Build 361165,564,812 - 65,573,227 (-)NCBI Archive
Celera1163,132,938 - 63,141,353 (-)RGD
HuRef1162,134,133 - 62,142,548 (-)ENTREZGENE
CHM1_11165,692,368 - 65,700,783 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018519   ⟹   XP_016874008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381166,041,059 - 66,045,371 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_149025   ⟸   NM_033036
- UniProtKB: Q96A11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016874008   ⟸   XM_017018519
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000308591   ⟸   ENST00000312006
RefSeq Acc Id: ENSP00000434829   ⟸   ENST00000527878

Promoters
RGD ID:6788952
Promoter ID:HG_KWN:13380
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid,   NB4
Transcripts:UC001OGV.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,569,044 - 65,569,544 (-)MPROMDB
RGD ID:7221119
Promoter ID:EPDNEW_H16305
Type:initiation region
Name:GAL3ST3_1
Description:galactose-3-O-sulfotransferase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381166,049,155 - 66,049,215EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_033036.3(GAL3ST3):c.234G>C (p.Thr78=) single nucleotide variant not provided [RCV000906401] Chr11:66043569 [GRCh38]
Chr11:65811040 [GRCh37]
Chr11:11q13.1
benign
NM_033036.3(GAL3ST3):c.740C>G (p.Ser247Trp) single nucleotide variant Esophageal atresia [RCV000984649] Chr11:66043063 [GRCh38]
Chr11:65810534 [GRCh37]
Chr11:11q13.1
uncertain significance
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2
pathogenic
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Autosomal recessive cutis laxa type 1B [RCV000798155] Chr11:65866431..66347555 [GRCh38]
Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NM_033036.3(GAL3ST3):c.1296A>G (p.Ter432Trp) single nucleotide variant none provided [RCV001284822] Chr11:66042507 [GRCh38]
Chr11:65809978 [GRCh37]
Chr11:11q13.1
uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Epilepsy, familial temporal lobe, 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Autosomal recessive cutis laxa type 1B [RCV001305354] Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24144 AgrOrtholog
COSMIC GAL3ST3 COSMIC
Ensembl Genes ENSG00000175229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000308591 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000434829 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000312006 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000527878 UniProtKB/Swiss-Prot
GTEx ENSG00000175229 GTEx
HGNC ID HGNC:24144 ENTREZGENE
Human Proteome Map GAL3ST3 Human Proteome Map
InterPro Gal-3-0_sulfotransfrase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report hsa:89792 UniProtKB/Swiss-Prot
NCBI Gene 89792 ENTREZGENE
OMIM 608234 OMIM
PANTHER PTHR14647 UniProtKB/Swiss-Prot
Pfam Gal-3-0_sulfotr UniProtKB/Swiss-Prot
PharmGKB PA134864180 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt G3ST3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q14D05 UniProtKB/Swiss-Prot