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Gene: NONO (non-POU domain containing octamer binding) Homo sapiens
Symbol: NONO
Name: non-POU domain containing octamer binding
Description: Exhibits identical protein binding activity. Involved in activation of innate immune response and negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Localizes to the fibrillar center; nuclear matrix; and paraspeckles. Implicated in syndromic X-linked intellectual disability 34.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 54 kDa nuclear RNA- and DNA-binding protein; 55 kDa nuclear protein; DNA-binding p52/p100 complex, 52 kDa subunit; MRXS34; NMT55; non-POU domain containing octamer-binding; non-POU domain containing, octamer-binding; non-POU domain-containing octamer (ATGCAAAT) binding protein; non-POU domain-containing octamer-binding protein; NRB54; P54; p54(nrb); P54NRB; PPP1R114
Mus musculus (house mouse) : Nono (non-POU-domain-containing, octamer binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nono (non-POU domain containing, octamer-binding)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nono (non-POU domain containing octamer binding)
Pan paniscus (bonobo/pygmy chimpanzee) : NONO (non-POU domain containing octamer binding)
Canis lupus familiaris (dog) : NONO (non-POU domain containing octamer binding)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nono (non-POU domain containing octamer binding)
Chlorocebus sabaeus (African green monkey) : NONO (non-POU domain containing octamer binding)
Heterocephalus glaber (naked mole-rat) : Nono (non-POU domain containing octamer binding)
more info ...
Related Pseudogenes: NONOP1   NONOP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX71,283,192 - 71,301,168 (+)Ensembl
GRCh38X71,283,192 - 71,301,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,503,042 - 70,521,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,420,192 - 70,437,743 (+)NCBINCBI36hg18NCBI36
Build 34X70,286,487 - 70,304,037NCBI
CeleraX70,856,920 - 70,874,896 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,319,299 - 64,337,309 (+)NCBIHuRef
CHM1_1X70,396,097 - 70,414,071 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NONO
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343083
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.