Gene: GPR150 (G protein-coupled receptor 150) Homo sapiens
Symbol: GPR150
Name: G protein-coupled receptor 150
Description: This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PGR11; probable G-protein coupled receptor 150; seven transmembrane helix receptor
Mus musculus (house mouse) : Gpr150 (G protein-coupled receptor 150)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpr150 (G protein-coupled receptor 150)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpr150 (G protein-coupled receptor 150)
Pan paniscus (bonobo/pygmy chimpanzee) : GPR150 (G protein-coupled receptor 150)
Canis lupus familiaris (dog) : GPR150 (G protein-coupled receptor 150)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpr150 (G protein-coupled receptor 150)
Sus scrofa (pig) : GPR150 (G protein-coupled receptor 150)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38595,620,078 - 95,622,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37594,955,980 - 94,957,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36594,981,736 - 94,983,040 (+)NCBINCBI36hg18NCBI36
Build 34594,981,735 - 94,983,040NCBI
Celera590,834,411 - 90,835,715 (+)NCBI
Cytogenetic Map5q15NCBI
HuRef590,146,328 - 90,147,632 (+)NCBIHuRef
CHM1_1594,388,653 - 94,389,957 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPR150
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343055
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.