MIR150 (microRNA 150) - Rat Genome Database

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Gene: MIR150 (microRNA 150) Homo sapiens
Analyze
Symbol: MIR150
Name: microRNA 150
RGD ID: 1342949
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; cellular response to phenylalanine; and long-term synaptic potentiation. Predicted to be part of RISC complex. Biomarker of chronic myeloid leukemia.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-150; MIRN150; miRNA150
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,500,785 - 49,500,868 (-)EnsemblGRCh38hg38GRCh38
GRCh381949,500,785 - 49,500,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,004,042 - 50,004,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,695,853 - 54,695,936 (-)NCBINCBI36hg18NCBI36
Celera1946,873,383 - 46,873,466 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,381,530 - 46,381,613 (-)NCBIHuRef
CHM1_11950,005,842 - 50,005,925 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

References

Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17438277   PMID:17604727   PMID:18667440   PMID:18682393   PMID:19615744   PMID:19823581   PMID:20067763   PMID:20075508   PMID:20218812   PMID:20460641  
PMID:20603081   PMID:21037258   PMID:21502955   PMID:21551231   PMID:21761366   PMID:21983127   PMID:22025269   PMID:22048026   PMID:22048267   PMID:22052060   PMID:22595456   PMID:23013135  
PMID:23079661   PMID:23159943   PMID:23211718   PMID:23220912   PMID:23228962   PMID:23326587   PMID:23372743   PMID:23521217   PMID:23547171   PMID:23554878   PMID:23670238   PMID:23673476  
PMID:23675407   PMID:23723424   PMID:23747308   PMID:23765923   PMID:23766514   PMID:23955084   PMID:24086639   PMID:24205408   PMID:24239242   PMID:24286416   PMID:24312495   PMID:24385540  
PMID:24456795   PMID:24462065   PMID:24532468   PMID:24613688   PMID:24633319   PMID:24698324   PMID:24768587   PMID:24787006   PMID:24828336   PMID:24907421   PMID:24960647   PMID:25090005  
PMID:25124610   PMID:25224332   PMID:25230975   PMID:25256711   PMID:25287716   PMID:25394245   PMID:25482320   PMID:25549355   PMID:25660363   PMID:25755784   PMID:25757558   PMID:25778313  
PMID:25924769   PMID:25986891   PMID:26025667   PMID:26069248   PMID:26077801   PMID:26095457   PMID:26148929   PMID:26215970   PMID:26237047   PMID:26258416   PMID:26287504   PMID:26361218  
PMID:26455323   PMID:26498874   PMID:26543232   PMID:26549736   PMID:26561465   PMID:26606907   PMID:26636522   PMID:26646931   PMID:26715362   PMID:26743170   PMID:26746193   PMID:26871477  
PMID:26935950   PMID:27117590   PMID:27154818   PMID:27216461   PMID:27226027   PMID:27246008   PMID:27285761   PMID:27329362   PMID:27338006   PMID:27377214   PMID:27447965   PMID:27586871  
PMID:27590507   PMID:27601730   PMID:27658773   PMID:27798914   PMID:27899822   PMID:27903978   PMID:27935859   PMID:27976702   PMID:28099946   PMID:28108217   PMID:28110404   PMID:28174235  
PMID:28254813   PMID:28259597   PMID:28286290   PMID:28399173   PMID:28407516   PMID:28466785   PMID:28534948   PMID:28577875   PMID:28639257   PMID:28656254   PMID:28659612   PMID:28696844  
PMID:28697764   PMID:28715868   PMID:28731457   PMID:28733034   PMID:28931826   PMID:29081413   PMID:29091902   PMID:29153954   PMID:29205062   PMID:29233721   PMID:29286099   PMID:29328381  
PMID:29335784   PMID:29386059   PMID:29488168   PMID:29512785   PMID:29516971   PMID:29607782   PMID:29618664   PMID:29654167   PMID:29689269   PMID:29690954   PMID:29750311   PMID:29901178  
PMID:29956871   PMID:29996115   PMID:30003924   PMID:30009782   PMID:30049824   PMID:30205391   PMID:30213873   PMID:30220021   PMID:30269036   PMID:30315850   PMID:30332984   PMID:30402842  
PMID:30422313   PMID:30476901   PMID:30502345   PMID:30566393   PMID:30569106   PMID:30569515   PMID:30570857   PMID:30575719   PMID:30610793   PMID:30628646   PMID:30679084   PMID:30732676  
PMID:30745540   PMID:30779068   PMID:30832601   PMID:30889053   PMID:30905898   PMID:30916832   PMID:30945700   PMID:30984166   PMID:31002133   PMID:31002820   PMID:31122130   PMID:31128917  
PMID:31159158   PMID:31182356   PMID:31306108   PMID:31318097   PMID:31398659   PMID:31410206   PMID:31537542   PMID:31569706   PMID:31570789   PMID:31600281   PMID:31669140   PMID:31722712  
PMID:31726456   PMID:31731194   PMID:31746410   PMID:31829306   PMID:31846199   PMID:31879859   PMID:31909455   PMID:31948396   PMID:32009256   PMID:32077254   PMID:32152450   PMID:32186927  
PMID:32196597   PMID:32196599   PMID:32246794   PMID:32250744   PMID:32436632   PMID:32827803   PMID:32853944   PMID:32883551   PMID:32924985   PMID:32945498   PMID:33015767   PMID:33031905  
PMID:33161598   PMID:33181172   PMID:33185898   PMID:33215445   PMID:33237144   PMID:33336724   PMID:33417998   PMID:33650672   PMID:33723215   PMID:34004247  


Genomics

Comparative Map Data
MIR150
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1949,500,785 - 49,500,868 (-)EnsemblGRCh38hg38GRCh38
GRCh381949,500,785 - 49,500,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,004,042 - 50,004,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,695,853 - 54,695,936 (-)NCBINCBI36hg18NCBI36
Celera1946,873,383 - 46,873,466 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,381,530 - 46,381,613 (-)NCBIHuRef
CHM1_11950,005,842 - 50,005,925 (-)NCBICHM1_1
Mir150
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,771,181 - 44,771,245 (+)NCBIGRCm39mm39
GRCm39 Ensembl744,771,181 - 44,771,245 (+)Ensembl
GRCm38745,121,757 - 45,121,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,121,757 - 45,121,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,377,127 - 52,377,191 (+)NCBIGRCm37mm9NCBIm37
Celera740,574,849 - 40,574,913 (+)NCBICelera
Cytogenetic Map7B3NCBI
Mir150
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,605,024 - 95,605,108 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl195,605,024 - 95,605,108 (+)Ensembl
Rnor_6.01101,115,974 - 101,116,058 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,115,974 - 101,116,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,181,484 - 102,181,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera189,863,441 - 89,863,525 (+)NCBICelera
Cytogenetic Map1q22NCBI
MIR150
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,998,756 - 106,998,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,998,756 - 106,998,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,582,032 - 106,582,088 (+)NCBI
ROS_Cfam_1.01107,518,817 - 107,518,873 (+)NCBI
UMICH_Zoey_3.11107,191,868 - 107,191,924 (+)NCBI
UNSW_CanFamBas_1.01106,834,021 - 106,834,077 (+)NCBI
UU_Cfam_GSD_1.01107,675,037 - 107,675,093 (+)NCBI
MIR150-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,580,912 - 54,580,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,580,912 - 54,580,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,309,879 - 50,309,955 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MYBhsa-miR-150-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Reporter Functional MTI18667440
MYBhsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18539114
MYBhsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18814950
MYBhsa-miR-150-5pMirtarbaseexternal_infoReporter assayFunctional MTI17923094
EGR2hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assay//semi-qRT-PCR//Western bFunctional MTI20067763
VEGFAhsa-miR-150-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI18320040
P2RX7hsa-miR-150-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assayFunctional MTI18682393
IGF2hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI21200031
CXCR4hsa-miR-150-5pMirtarbaseexternal_infoFACS//Western blotFunctional MTI22039399
ZEB1hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23013135
NOTCH3hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21551231
FLT3hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23079661
EP300hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23211718
PTPRRhsa-miR-150-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20218812
ATP13A3hsa-miR-150-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TP53hsa-miR-150-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23747308
MYBhsa-miR-150-5pTarbaseexternal_infoReporter GenePOSITIVE
AGAhsa-miR-150-5pTarbaseexternal_infoMicroarrayPOSITIVE
MYBhsa-miR-150-5pTarbaseexternal_infoWesternblitPOSITIVE
MYBhsa-miR-150-5pTarbaseexternal_infoOtherPOSITIVE
MYBhsa-miR-150-5pMirecordsexternal_info{changed}NA18667440
MYBhsa-miR-150-5pMirecordsexternal_info{changed}NA18814950
MYBhsa-miR-150-5pMirecordsexternal_infoNANA18539114
P2RX7hsa-miR-150-5pMirecordsexternal_infoNANA18682393
EGR2hsa-miR-150-5pMirecordsexternal_info{changed}NA20067763
MUC4hsa-miR-150-5pMirecordsexternal_info{unchanged}NA21983127
FLT3hsa-miR-150-5pOncomiRDBexternal_infoNANA23079661
ZEB1hsa-miR-150-5pOncomiRDBexternal_infoNANA23013135
MYBhsa-miR-150-5pOncomiRDBexternal_infoNANA22025269
MUC4hsa-miR-150-5pOncomiRDBexternal_infoNANA21983127
DKC1hsa-miR-150-5pOncomiRDBexternal_infoNANA21502955
EGR2hsa-miR-150-5pOncomiRDBexternal_infoNANA20067763
P2RX7hsa-miR-150-5pOncomiRDBexternal_infoNANA18682393

Predicted Targets
Summary Value
Count of predictions:37493
Count of gene targets:14075
Count of transcripts:28072
Interacting mature miRNAs:hsa-miR-150-3p, hsa-miR-150-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 7 3 10 6 1 1 1 3
Low 51 47 43 7 66 5 128 38 58 6 37 56 2 28 76
Below cutoff 41 53 28 10 51 10 86 43 65 6 17 20 3 34 45

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385048
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1949,500,785 - 49,500,868 (-)Ensembl
RefSeq Acc Id: NR_029703
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,500,785 - 49,500,868 (-)NCBI
GRCh371950,004,042 - 50,004,125 (-)RGD
Celera1946,873,383 - 46,873,466 (-)RGD
HuRef1946,381,530 - 46,381,613 (-)ENTREZGENE
CHM1_11950,005,842 - 50,005,925 (-)NCBI
Sequence:
Promoters
RGD ID:6814647
Promoter ID:HG_XEF:4183
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:NR_029560,   NR_030972,   NR_031893,   NR_032422
Position:
Human AssemblyChrPosition (strand)Source
Build 361954,695,674 - 54,696,174 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q13.33(chr19:49600909-51366070)x3 copy number gain not provided [RCV000847250] Chr19:49600909..51366070 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31537 AgrOrtholog
COSMIC MIR150 COSMIC
Ensembl Genes ENSG00000207782 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385048 ENTREZGENE
GTEx ENSG00000207782 GTEx
HGNC ID HGNC:31537 ENTREZGENE
Human Proteome Map MIR150 Human Proteome Map
miRBase MI0000479 ENTREZGENE
NCBI Gene 406942 ENTREZGENE
OMIM 611114 OMIM
PharmGKB PA164722506 PharmGKB
RNAcentral URS000016FD1A RNACentral
  URS00005EAAAD RNACentral
  URS00006B7D0F RNACentral