ZHX2 (zinc fingers and homeoboxes 2) - Rat Genome Database

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Gene: ZHX2 (zinc fingers and homeoboxes 2) Homo sapiens
Analyze
Symbol: ZHX2
Name: zinc fingers and homeoboxes 2
RGD ID: 1342946
HGNC Page HGNC
Description: Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AFP regulator 1; AFR1; alpha-fetoprotein regulator 1; KIAA0854; RAF; regulator of AFP; RP11-44N11.3; transcription factor ZHX2; zinc finger and homeodomain protein 2; zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8122,781,655 - 122,974,510 (+)EnsemblGRCh38hg38GRCh38
GRCh388122,781,655 - 122,974,514 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378123,793,894 - 123,986,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368123,863,082 - 124,055,936 (+)NCBINCBI36hg18NCBI36
Build 348123,863,169 - 124,055,929NCBI
Celera8119,982,978 - 120,175,825 (+)NCBI
Cytogenetic Map8q24.13NCBI
HuRef8119,119,533 - 119,312,420 (+)NCBIHuRef
CHM1_18123,834,160 - 124,026,965 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISA)
cytosol  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA)

References

Additional References at PubMed
PMID:9092538   PMID:10048485   PMID:11205744   PMID:12477932   PMID:14659886   PMID:15489334   PMID:15824104   PMID:16713569   PMID:16952470   PMID:16968750   PMID:17056598   PMID:17447851  
PMID:17533377   PMID:18029348   PMID:18194454   PMID:19240061   PMID:19274049   PMID:19805522   PMID:20080650   PMID:20379614   PMID:21443521   PMID:21832049   PMID:21873635   PMID:21909108  
PMID:21987443   PMID:21988832   PMID:22078940   PMID:22542470   PMID:22661463   PMID:22984075   PMID:23942779   PMID:25195714   PMID:25473899   PMID:25746325   PMID:26496610   PMID:26679602  
PMID:28152006   PMID:28258223   PMID:28514442   PMID:28611215   PMID:29507755   PMID:29509190   PMID:29580980   PMID:29656893   PMID:29752719   PMID:30021884   PMID:30026228   PMID:30784286  
PMID:31527615   PMID:31683461   PMID:32114388   PMID:32382017   PMID:32770671   PMID:32814053  


Genomics

Comparative Map Data
ZHX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8122,781,655 - 122,974,510 (+)EnsemblGRCh38hg38GRCh38
GRCh388122,781,655 - 122,974,514 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378123,793,894 - 123,986,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368123,863,082 - 124,055,936 (+)NCBINCBI36hg18NCBI36
Build 348123,863,169 - 124,055,929NCBI
Celera8119,982,978 - 120,175,825 (+)NCBI
Cytogenetic Map8q24.13NCBI
HuRef8119,119,533 - 119,312,420 (+)NCBIHuRef
CHM1_18123,834,160 - 124,026,965 (+)NCBICHM1_1
Zhx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391557,558,063 - 57,703,228 (+)NCBIGRCm39mm39
GRCm39 Ensembl1557,558,061 - 57,703,228 (+)Ensembl
GRCm381557,694,667 - 57,839,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1557,694,665 - 57,839,832 (+)EnsemblGRCm38mm10GRCm38
MGSCv371557,526,222 - 57,671,387 (+)NCBIGRCm37mm9NCBIm37
MGSCv361557,524,854 - 57,669,854 (+)NCBImm8
Celera1559,214,205 - 59,360,402 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1524.01NCBI
Zhx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2789,226,358 - 89,374,266 (+)NCBI
Rnor_6.0 Ensembl797,559,841 - 97,695,739 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0797,559,653 - 97,707,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0798,166,854 - 98,314,735 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,528,435 - 94,530,945 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1794,563,246 - 94,563,739 (+)NCBI
Celera786,000,415 - 86,135,018 (+)NCBICelera
Cytogenetic Map7q33NCBI
Zhx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555401,805,666 - 1,890,409 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555401,805,648 - 1,890,409 (+)NCBIChiLan1.0ChiLan1.0
ZHX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18122,306,315 - 122,424,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8122,401,567 - 122,404,080 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08119,473,607 - 119,668,790 (+)NCBIMhudiblu_PPA_v0panPan3
ZHX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11321,231,985 - 21,393,756 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1321,377,316 - 21,379,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1321,342,934 - 21,359,598 (+)NCBI
ROS_Cfam_1.01321,568,837 - 21,730,547 (+)NCBI
UMICH_Zoey_3.11321,297,771 - 21,459,250 (+)NCBI
UNSW_CanFamBas_1.01321,402,546 - 21,564,353 (+)NCBI
UU_Cfam_GSD_1.01321,645,278 - 21,807,009 (+)NCBI
Zhx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530316,889,272 - 17,048,441 (-)NCBI
SpeTri2.0NW_00493647024,315,371 - 24,476,063 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZHX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl416,374,900 - 16,553,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1416,374,900 - 16,553,859 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2417,144,095 - 17,315,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZHX2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18117,360,134 - 117,550,818 (+)NCBI
ChlSab1.1 Ensembl8117,531,654 - 117,534,167 (+)Ensembl
Vero_WHO_p1.0NW_02366603922,683,909 - 22,875,372 (-)NCBI
Zhx2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473531,882,434 - 32,013,773 (-)NCBI

Position Markers
D8S1826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,856,168 - 123,856,326UniSTSGRCh37
Build 368123,925,349 - 123,925,507RGDNCBI36
Celera8120,045,248 - 120,045,406RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,181,863 - 119,182,021UniSTS
Marshfield Genetic Map8130.0UniSTS
Marshfield Genetic Map8130.0RGD
Genethon Genetic Map8128.8UniSTS
deCODE Assembly Map8125.72UniSTS
GeneMap99-GB4 RH Map8476.41UniSTS
Whitehead-YAC Contig Map8 UniSTS
NCBI RH Map81463.9UniSTS
WI-17139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,895,717 - 123,895,842UniSTSGRCh37
Build 368123,964,898 - 123,965,023RGDNCBI36
Celera8120,084,779 - 120,084,904RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,221,388 - 119,221,513UniSTS
GeneMap99-GB4 RH Map8474.57UniSTS
Whitehead-RH Map8641.4UniSTS
RH119894  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,908,110 - 123,908,385UniSTSGRCh37
Build 368123,977,291 - 123,977,566RGDNCBI36
Celera8120,097,172 - 120,097,447RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,233,767 - 119,234,042UniSTS
TNG Radiation Hybrid Map859852.0UniSTS
G59722  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,986,595 - 123,986,722UniSTSGRCh37
Build 368124,055,776 - 124,055,903RGDNCBI36
Celera8120,175,665 - 120,175,792RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,312,260 - 119,312,387UniSTS
TNG Radiation Hybrid Map859908.0UniSTS
SHGC-110247  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,916,048 - 123,916,329UniSTSGRCh37
Build 368123,985,229 - 123,985,510RGDNCBI36
Celera8120,105,109 - 120,105,390RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,241,704 - 119,241,985UniSTS
TNG Radiation Hybrid Map859865.0UniSTS
SHGC-111296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,970,052 - 123,970,160UniSTSGRCh37
Build 368124,039,233 - 124,039,341RGDNCBI36
Celera8120,159,123 - 120,159,231RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,295,711 - 119,295,819UniSTS
TNG Radiation Hybrid Map859900.0UniSTS
SHGC-111728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,908,219 - 123,908,549UniSTSGRCh37
Build 368123,977,400 - 123,977,730RGDNCBI36
Celera8120,097,281 - 120,097,611RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,233,876 - 119,234,206UniSTS
TNG Radiation Hybrid Map859855.0UniSTS
SHGC-147748  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,914,795 - 123,915,102UniSTSGRCh37
Build 368123,983,976 - 123,984,283RGDNCBI36
Celera8120,103,857 - 120,104,164RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,240,452 - 119,240,759UniSTS
TNG Radiation Hybrid Map859862.0UniSTS
SHGC-149547  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,915,149 - 123,915,421UniSTSGRCh37
Build 368123,984,330 - 123,984,602RGDNCBI36
Celera8120,104,211 - 120,104,482RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,240,806 - 119,241,077UniSTS
TNG Radiation Hybrid Map859865.0UniSTS
RH47173  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,985,925 - 123,986,082UniSTSGRCh37
Build 368124,055,106 - 124,055,263RGDNCBI36
Celera8120,174,995 - 120,175,152RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,311,590 - 119,311,747UniSTS
GeneMap99-GB4 RH Map8477.8UniSTS
NCBI RH Map81461.6UniSTS
WI-12680  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,934,360 - 123,934,509UniSTSGRCh37
Build 368124,003,541 - 124,003,690RGDNCBI36
Celera8120,123,420 - 120,123,569RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,260,015 - 119,260,164UniSTS
GeneMap99-GB4 RH Map8474.57UniSTS
Whitehead-RH Map8641.4UniSTS
NCBI RH Map81411.1UniSTS
WI-16838  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,869,407 - 123,869,556UniSTSGRCh37
Build 368123,938,588 - 123,938,737RGDNCBI36
Celera8120,058,487 - 120,058,636RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,195,102 - 119,195,251UniSTS
GeneMap99-GB4 RH Map8474.57UniSTS
Whitehead-RH Map8641.4UniSTS
SGC34057  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,898,094 - 123,898,243UniSTSGRCh37
Build 368123,967,275 - 123,967,424RGDNCBI36
Celera8120,087,156 - 120,087,305RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,223,765 - 119,223,914UniSTS
GeneMap99-GB4 RH Map8474.38UniSTS
Whitehead-RH Map8641.4UniSTS
RH41900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,986,591 - 123,986,713UniSTSGRCh37
Build 368124,055,772 - 124,055,894RGDNCBI36
Celera8120,175,661 - 120,175,783RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,312,256 - 119,312,378UniSTS
GeneMap99-GB4 RH Map8477.8UniSTS
NCBI RH Map81468.4UniSTS
SGC35165  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,810,226 - 123,810,355UniSTSGRCh37
Build 368123,879,407 - 123,879,536RGDNCBI36
Celera8119,999,305 - 119,999,434RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,135,864 - 119,135,993UniSTS
GeneMap99-GB4 RH Map8478.86UniSTS
Whitehead-RH Map8639.9UniSTS
STS-AA010366  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,809,721 - 123,809,949UniSTSGRCh37
Build 368123,878,902 - 123,879,130RGDNCBI36
Celera8119,998,799 - 119,999,028RGD
Cytogenetic Map8q24.13UniSTS
HuRef1142,675,824 - 142,676,053UniSTS
HuRef8119,135,358 - 119,135,587UniSTS
GeneMap99-GB4 RH Map8470.44UniSTS
WI-14759  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,986,589 - 123,986,722UniSTSGRCh37
Build 368124,055,770 - 124,055,903RGDNCBI36
Celera8120,175,659 - 120,175,792RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,312,254 - 119,312,387UniSTS
GeneMap99-GB4 RH Map8476.41UniSTS
Whitehead-RH Map8642.7UniSTS
NCBI RH Map81461.6UniSTS
RH16365  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378123,810,347 - 123,810,486UniSTSGRCh37
Build 368123,879,528 - 123,879,667RGDNCBI36
Celera8119,999,426 - 119,999,565RGD
Cytogenetic Map8q24.13UniSTS
HuRef8119,135,985 - 119,136,124UniSTS
GeneMap99-GB4 RH Map8477.8UniSTS
NCBI RH Map81461.6UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:776
Count of miRNA genes:589
Interacting mature miRNAs:642
Transcripts:ENST00000314393, ENST00000534247
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1859 2160 1481 410 1420 264 4107 1980 2599 286 1039 1469 158 1118 2723 1
Low 567 823 241 211 518 199 247 213 1108 131 403 137 13 86 65 1
Below cutoff 2 1 1 1 7 1 1 3 1 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_046951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB083653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF075099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI334237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM148156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY099683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000314393   ⟹   ENSP00000314709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8122,781,655 - 122,974,510 (+)Ensembl
RefSeq Acc Id: ENST00000534247   ⟹   ENSP00000452720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8122,863,385 - 122,952,009 (+)Ensembl
RefSeq Acc Id: NM_001362797   ⟹   NP_001349726
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,781,655 - 122,974,510 (+)NCBI
RefSeq Acc Id: NM_014943   ⟹   NP_055758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,781,655 - 122,974,510 (+)NCBI
GRCh378123,792,510 - 123,986,755 (+)NCBI
Build 368123,863,082 - 124,055,936 (+)NCBI Archive
HuRef8119,119,533 - 119,312,420 (+)ENTREZGENE
CHM1_18123,834,160 - 124,026,965 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005250836   ⟹   XP_005250893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,821,855 - 122,974,460 (+)NCBI
GRCh378123,792,510 - 123,986,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516932   ⟹   XP_011515234
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,821,855 - 122,974,514 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_055758   ⟸   NM_014943
- UniProtKB: Q9Y6X8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005250893   ⟸   XM_005250836
- Peptide Label: isoform X1
- UniProtKB: Q9Y6X8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011515234   ⟸   XM_011516932
- Peptide Label: isoform X1
- UniProtKB: Q9Y6X8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001349726   ⟸   NM_001362797
RefSeq Acc Id: ENSP00000452720   ⟸   ENST00000534247
RefSeq Acc Id: ENSP00000314709   ⟸   ENST00000314393
Protein Domains
C2H2-type

Promoters
RGD ID:7214093
Promoter ID:EPDNEW_H12793
Type:initiation region
Name:ZHX2_1
Description:zinc fingers and homeoboxes 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12794  EPDNEW_H12795  EPDNEW_H12796  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,780,403 - 122,780,463EPDNEW
RGD ID:7214095
Promoter ID:EPDNEW_H12794
Type:initiation region
Name:ZHX2_2
Description:zinc fingers and homeoboxes 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12793  EPDNEW_H12795  EPDNEW_H12796  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,781,306 - 122,781,366EPDNEW
RGD ID:7214097
Promoter ID:EPDNEW_H12795
Type:initiation region
Name:ZHX2_4
Description:zinc fingers and homeoboxes 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12793  EPDNEW_H12794  EPDNEW_H12796  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,781,441 - 122,781,501EPDNEW
RGD ID:7214099
Promoter ID:EPDNEW_H12796
Type:initiation region
Name:ZHX2_3
Description:zinc fingers and homeoboxes 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12793  EPDNEW_H12794  EPDNEW_H12795  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388122,781,771 - 122,781,831EPDNEW
RGD ID:6807179
Promoter ID:HG_KWN:62006
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014943
Position:
Human AssemblyChrPosition (strand)Source
Build 368123,862,644 - 123,863,144 (+)MPROMDB
RGD ID:6807180
Promoter ID:HG_KWN:62008
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC010MDH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368124,034,941 - 124,035,441 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.13(chr8:122751607-123361569)x3 copy number gain See cases [RCV000050761] Chr8:122751607..123361569 [GRCh38]
Chr8:123763846..124373809 [GRCh37]
Chr8:123833027..124442990 [NCBI36]
Chr8:8q24.13
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.3-24.21(chr8:113288454-126716087)x1 copy number loss See cases [RCV000054301] Chr8:113288454..126716087 [GRCh38]
Chr8:114300683..127728332 [GRCh37]
Chr8:114369859..127797514 [NCBI36]
Chr8:8q23.3-24.21
pathogenic
NM_014943.3(ZHX2):c.1660C>T (p.Pro554Ser) single nucleotide variant Malignant melanoma [RCV000068136] Chr8:122953170 [GRCh38]
Chr8:123965410 [GRCh37]
Chr8:124034591 [NCBI36]
Chr8:8q24.13
not provided
NM_014943.3(ZHX2):c.-717C>T single nucleotide variant Lung cancer [RCV000106998] Chr8:122781512 [GRCh38]
Chr8:123793751 [GRCh37]
Chr8:8q24.13
uncertain significance
NM_014943.3(ZHX2):c.-282-10978A>G single nucleotide variant Lung cancer [RCV000106999] Chr8:122852499 [GRCh38]
Chr8:123864738 [GRCh37]
Chr8:8q24.13
uncertain significance
NM_014943.3(ZHX2):c.-219-30899A>T single nucleotide variant Lung cancer [RCV000107000] Chr8:122920393 [GRCh38]
Chr8:123932633 [GRCh37]
Chr8:8q24.13
uncertain significance
NM_014943.3(ZHX2):c.-219-2587G>T single nucleotide variant Lung cancer [RCV000107001] Chr8:122948705 [GRCh38]
Chr8:123960945 [GRCh37]
Chr8:8q24.13
uncertain significance
GRCh38/hg38 8q24.13-24.21(chr8:122454392-128513076)x3 copy number gain See cases [RCV000133620] Chr8:122454392..128513076 [GRCh38]
Chr8:123466631..129525322 [GRCh37]
Chr8:123535812..129594504 [NCBI36]
Chr8:8q24.13-24.21
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
NM_014943.5(ZHX2):c.1682G>A (p.Arg561Gln) single nucleotide variant Hirschsprung disease 1 [RCV000201300] Chr8:122953192 [GRCh38]
Chr8:123965432 [GRCh37]
Chr8:8q24.13
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
Single allele deletion Trichorhinophalangeal dysplasia type I [RCV000735900] Chr8:114508086..129040004 [GRCh37]
Chr8:8q23.3-24.21
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_014943.5(ZHX2):c.2302A>G (p.Thr768Ala) single nucleotide variant not provided [RCV000883272] Chr8:122953812 [GRCh38]
Chr8:123966052 [GRCh37]
Chr8:8q24.13
likely benign
NM_014943.5(ZHX2):c.330C>T (p.Tyr110=) single nucleotide variant not provided [RCV000965084] Chr8:122951840 [GRCh38]
Chr8:123964080 [GRCh37]
Chr8:8q24.13
benign
NM_014943.5(ZHX2):c.2044T>C (p.Leu682=) single nucleotide variant not provided [RCV000893742] Chr8:122953554 [GRCh38]
Chr8:123965794 [GRCh37]
Chr8:8q24.13
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
NM_014943.5(ZHX2):c.1734G>A (p.Ser578=) single nucleotide variant not provided [RCV000965450] Chr8:122953244 [GRCh38]
Chr8:123965484 [GRCh37]
Chr8:8q24.13
benign
GRCh37/hg19 8q24.13-24.21(chr8:123074293-131113892)x1 copy number loss not provided [RCV000848164] Chr8:123074293..131113892 [GRCh37]
Chr8:8q24.13-24.21
pathogenic
NM_014943.5(ZHX2):c.634G>A (p.Val212Met) single nucleotide variant not provided [RCV000956669] Chr8:122952144 [GRCh38]
Chr8:123964384 [GRCh37]
Chr8:8q24.13
benign
NM_014943.5(ZHX2):c.1005C>T (p.Asn335=) single nucleotide variant not provided [RCV000889699] Chr8:122952515 [GRCh38]
Chr8:123964755 [GRCh37]
Chr8:8q24.13
benign
GRCh37/hg19 8q24.12-24.13(chr8:121938227-125485728)x1 copy number loss not provided [RCV001281354] Chr8:121938227..125485728 [GRCh37]
Chr8:8q24.12-24.13
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18513 AgrOrtholog
COSMIC ZHX2 COSMIC
Ensembl Genes ENSG00000178764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000314709 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000452720 UniProtKB/TrEMBL
Ensembl Transcript ENST00000314393 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000534247 UniProtKB/TrEMBL
GTEx ENSG00000178764 GTEx
HGNC ID HGNC:18513 ENTREZGENE
Human Proteome Map ZHX2 Human Proteome Map
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  ZHX_Znf_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:22882 UniProtKB/Swiss-Prot
NCBI Gene 22882 ENTREZGENE
OMIM 609185 OMIM
Pfam Homeodomain UniProtKB/Swiss-Prot
  zf_C2H2_ZHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA128394591 PharmGKB
PROSITE HOMEOBOX_2 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H0YKA3_HUMAN UniProtKB/TrEMBL
  Q9Y6X8 ENTREZGENE, UniProtKB/Swiss-Prot