Gkn2 (gastrokine 2) - Rat Genome Database
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Gene: Gkn2 (gastrokine 2) Mus musculus
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Symbol: Gkn2
Name: gastrokine 2
RGD ID: 1332561
MGI Page MGI
Description: Is expressed in reproductive system; stomach; trunk; and yolk sac. Orthologous to human GKN2 (gastrokine 2); INTERACTS WITH 4,4'-sulfonyldiphenol; all-trans-retinoic acid; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1810036H07Rik; blottin; Bricd; Bricd1b; gastrokine-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,350,347 - 87,356,476 (+)NCBIGRCm39mm39
GRCm39 Ensembl687,350,339 - 87,356,479 (+)Ensembl
GRCm38687,373,365 - 87,379,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,373,357 - 87,379,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv37687,323,359 - 87,329,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv36687,338,999 - 87,345,128 (+)NCBImm8
Celera689,312,408 - 89,318,547 (+)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16888721   PMID:20562862   PMID:21677750   PMID:21873635   PMID:23012479  
PMID:24194600   PMID:25290738   PMID:26839965   PMID:26974160   PMID:27626380   PMID:28467908   PMID:31668390   PMID:32226647   PMID:32358519  


Genomics

Comparative Map Data
Gkn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,350,347 - 87,356,476 (+)NCBIGRCm39mm39
GRCm39 Ensembl687,350,339 - 87,356,479 (+)Ensembl
GRCm38687,373,365 - 87,379,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,373,357 - 87,379,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv37687,323,359 - 87,329,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv36687,338,999 - 87,345,128 (+)NCBImm8
Celera689,312,408 - 89,318,547 (+)NCBICelera
Cytogenetic Map6D1NCBI
GKN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl268,945,232 - 68,952,893 (-)EnsemblGRCh38hg38GRCh38
GRCh38268,945,232 - 68,952,893 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37269,172,364 - 69,180,025 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,025,868 - 69,033,606 (-)NCBINCBI36hg18NCBI36
Celera269,023,098 - 69,030,721 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef268,908,590 - 68,916,329 (-)NCBIHuRef
CHM1_1269,101,686 - 69,109,425 (-)NCBICHM1_1
Gkn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24119,778,326 - 119,824,366 (+)NCBI
Rnor_6.0 Ensembl4119,171,245 - 119,177,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04119,131,255 - 119,177,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04183,699,839 - 183,746,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,524,326 - 121,530,410 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14121,766,678 - 121,774,891 (+)NCBI
Celera4108,788,548 - 108,794,630 (+)NCBICelera
Cytogenetic Map4q34NCBI
Gkn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,071,246 - 16,078,008 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,071,246 - 16,078,008 (+)NCBIChiLan1.0ChiLan1.0
GKN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A70,108,200 - 70,115,918 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,107,973 - 70,115,918 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A68,986,424 - 68,994,148 (-)NCBIMhudiblu_PPA_v0panPan3
GKN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1067,766,290 - 67,774,194 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11067,766,659 - 67,773,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gkn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649113,233,729 - 13,238,305 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GKN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,443,846 - 73,452,046 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,443,856 - 73,451,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2376,885,074 - 76,893,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GKN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,171,433 - 38,179,689 (+)NCBI
ChlSab1.1 Ensembl1438,172,306 - 38,179,457 (+)Ensembl
Gkn2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247624,420,481 - 4,432,701 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:66
Interacting mature miRNAs:66
Transcripts:ENSMUST00000032128
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032128   ⟹   ENSMUSP00000032128
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,373,357 - 87,379,497 (+)Ensembl
RefSeq Acc Id: NM_025467   ⟹   NP_079743
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39687,350,347 - 87,356,476 (+)NCBI
GRCm38687,373,365 - 87,379,494 (+)ENTREZGENE
MGSCv37687,323,359 - 87,329,488 (+)RGD
Celera689,312,408 - 89,318,547 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079743   ⟸   NM_025467
- Peptide Label: precursor
- UniProtKB: Q9CQS6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032128   ⟸   ENSMUST00000032128
Protein Domains
BRICHOS

Promoters
RGD ID:6890324
Promoter ID:EPDNEW_M8613
Type:multiple initiation site
Name:Gkn2_1
Description:Mus musculus gastrokine 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38687,373,365 - 87,373,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913534 AgrOrtholog
Ensembl Genes ENSMUSG00000030049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032128 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032128 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro BRICHOS_dom UniProtKB/Swiss-Prot
KEGG Report mmu:66284 UniProtKB/Swiss-Prot
MGD MGI:1913534 ENTREZGENE
NCBI Gene 66284 ENTREZGENE
Pfam BRICHOS UniProtKB/Swiss-Prot
PhenoGen Gkn2 PhenoGen
PROSITE BRICHOS UniProtKB/Swiss-Prot
SMART BRICHOS UniProtKB/Swiss-Prot
UniProt GKN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE