Heatr3 (HEAT repeat containing 3) - Rat Genome Database
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Gene: Heatr3 (HEAT repeat containing 3) Mus musculus
Analyze
Symbol: Heatr3
Name: HEAT repeat containing 3
RGD ID: 1332478
MGI Page MGI
Description: Predicted to have unfolded protein binding activity. Predicted to be involved in protein import into nucleus and ribosomal large subunit biogenesis. Orthologous to human HEATR3 (HEAT repeat containing 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; ferric oxide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C030036P15Rik; HEAT repeat-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,864,453 - 88,901,656 (+)NCBIGRCm39mm39
GRCm38888,137,885 - 88,171,952 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,137,855 - 88,172,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,661,784 - 90,695,851 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,027,990 - 91,062,057 (+)NCBImm8
Celera892,409,477 - 92,444,792 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21873635  
PMID:24457600   PMID:26365490  


Genomics

Comparative Map Data
Heatr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,864,453 - 88,901,656 (+)NCBIGRCm39mm39
GRCm38888,137,885 - 88,171,952 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,137,855 - 88,172,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,661,784 - 90,695,851 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,027,990 - 91,062,057 (+)NCBImm8
Celera892,409,477 - 92,444,792 (+)NCBICelera
Cytogenetic Map8C3NCBI
HEATR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,065,970 - 50,107,272 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,065,941 - 50,107,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,099,881 - 50,139,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,657,382 - 48,696,893 (+)NCBINCBI36hg18NCBI36
Celera1634,613,203 - 34,679,975 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1635,988,200 - 36,053,654 (+)NCBIHuRef
CHM1_11651,507,140 - 51,546,658 (+)NCBICHM1_1
Heatr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01919,858,419 - 19,896,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,858,416 - 19,896,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,883,214 - 30,921,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,204,999 - 20,242,364 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11920,210,399 - 20,247,067 (-)NCBI
Celera1918,777,148 - 18,815,511 (-)NCBICelera
Cytogenetic Map19p11NCBI
Heatr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,183,395 - 8,224,117 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,183,701 - 8,224,117 (+)NCBIChiLan1.0ChiLan1.0
HEATR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,212,645 - 49,251,043 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,212,645 - 49,251,043 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,329,163 - 30,369,658 (+)NCBIMhudiblu_PPA_v0panPan3
HEATR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl265,151,717 - 65,218,109 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1265,178,268 - 65,218,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Heatr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364753,189,008 - 3,222,242 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEATR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,597,636 - 34,759,216 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,706,561 - 34,759,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HEATR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1535,865,090 - 35,906,611 (+)NCBI
ChlSab1.1 Ensembl535,865,134 - 35,908,271 (+)Ensembl
Heatr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247576,522,808 - 6,597,460 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:833
Count of miRNA genes:415
Interacting mature miRNAs:463
Transcripts:ENSMUST00000034079, ENSMUST00000121949, ENSMUST00000131682, ENSMUST00000137452, ENSMUST00000146946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034079   ⟹   ENSMUSP00000034079
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl888,137,855 - 88,172,027 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121949   ⟹   ENSMUSP00000112812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl888,137,856 - 88,171,997 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131682
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl888,157,065 - 88,158,745 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137452
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl888,164,482 - 88,167,045 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146946
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl888,161,518 - 88,172,027 (+)Ensembl
RefSeq Acc Id: NM_172757   ⟹   NP_766345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39888,864,513 - 88,898,580 (+)NCBI
GRCm38888,137,885 - 88,171,952 (+)ENTREZGENE
MGSCv37890,661,784 - 90,695,851 (+)RGD
Celera892,409,477 - 92,444,792 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004934819
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39888,864,453 - 88,901,656 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_766345   ⟸   NM_172757
- UniProtKB: Q8BQM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034079   ⟸   ENSMUST00000034079
RefSeq Acc Id: ENSMUSP00000112812   ⟸   ENSMUST00000121949

Promoters
RGD ID:8667805
Promoter ID:EPDNEW_M11934
Type:initiation region
Name:Heatr3_1
Description:Mus musculus HEAT repeat containing 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38888,137,875 - 88,137,935EPDNEW
RGD ID:6843289
Promoter ID:MM_KWN:55194
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000121949,   OTTMUST00000076961
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36890,661,331 - 90,662,012 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444491 AgrOrtholog
Ensembl Genes ENSMUSG00000031657 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034079 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000112812 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034079 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000121949 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234549 UniProtKB/Swiss-Prot
MGD MGI:2444491 ENTREZGENE
NCBI Gene 234549 ENTREZGENE
PhenoGen Heatr3 PhenoGen
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.36291 ENTREZGENE
UniProt E9PWH6_MOUSE UniProtKB/TrEMBL
  HEAT3_MOUSE UniProtKB/Swiss-Prot
  Q3TQJ6_MOUSE UniProtKB/TrEMBL
  Q3USC0_MOUSE UniProtKB/TrEMBL
  Q80VH5_MOUSE UniProtKB/TrEMBL
  Q8BQM4 ENTREZGENE
  Q8BRI7_MOUSE UniProtKB/TrEMBL
  Q8K2Q1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8C731 UniProtKB/Swiss-Prot