Mri1 (methylthioribose-1-phosphate isomerase 1) - Rat Genome Database
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Gene: Mri1 (methylthioribose-1-phosphate isomerase 1) Mus musculus
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Symbol: Mri1
Name: methylthioribose-1-phosphate isomerase 1
RGD ID: 1332408
MGI Page MGI
Description: Predicted to have S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to localize to cytosol; fibrillar center; and nucleoplasm. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; chromium(6+).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410018C20Rik; M1Pi; methylthioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,977,205 - 84,983,953 (-)NCBIGRCm39mm39
GRCm38884,250,576 - 84,257,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,249,906 - 84,257,326 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,774,475 - 86,781,223 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,140,011 - 87,147,431 (-)NCBImm8
Celera888,552,772 - 88,559,465 (-)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
fibrillar center  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073   PMID:20059953   PMID:21267068   PMID:21873635  
PMID:30333137  


Genomics

Comparative Map Data
Mri1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,977,205 - 84,983,953 (-)NCBIGRCm39mm39
GRCm38884,250,576 - 84,257,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,249,906 - 84,257,326 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,774,475 - 86,781,223 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,140,011 - 87,147,431 (-)NCBImm8
Celera888,552,772 - 88,559,465 (-)NCBICelera
Cytogenetic Map8C2NCBI
MRI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,764,522 - 13,774,282 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,764,492 - 13,774,282 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,875,328 - 13,885,096 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,736,337 - 13,746,096 (+)NCBINCBI36hg18NCBI36
Celera1913,769,122 - 13,778,884 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1913,447,016 - 13,456,733 (+)NCBIHuRef
CHM1_11913,875,880 - 13,885,599 (+)NCBICHM1_1
Mri1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,360,299 - 25,366,283 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,360,164 - 25,366,806 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,336,487 - 36,342,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,591,115 - 25,597,099 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,595,940 - 25,601,925 (+)NCBI
Celera1923,456,210 - 23,462,198 (+)NCBICelera
Cytogenetic Map19q11NCBI
Mri1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,585,756 - 32,589,261 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,585,714 - 32,589,343 (+)NCBIChiLan1.0ChiLan1.0
MRI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,060,777 - 14,067,521 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,060,859 - 14,067,222 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,327,569 - 13,336,286 (+)NCBIMhudiblu_PPA_v0panPan3
MRI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,653,152 - 48,658,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,648,987 - 48,658,231 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mri1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,526,274 - 2,532,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,348,004 - 65,354,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,348,609 - 65,354,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,675,853 - 65,682,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRI1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,424,835 - 12,431,911 (+)NCBI
ChlSab1.1 Ensembl612,425,052 - 12,431,844 (+)Ensembl
Mri1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,105,763 - 1,110,281 (+)NCBI

Position Markers
RH118315  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,255,204 - 84,255,355UniSTSGRCm38
MGSCv37886,779,103 - 86,779,254UniSTSGRCm37
Celera888,557,341 - 88,557,492UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH8998.98UniSTS
RH126162  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,258,372 - 84,258,605UniSTSGRCm38
MGSCv37886,782,271 - 86,782,504UniSTSGRCm37
Celera888,560,508 - 88,560,741UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH81004.96UniSTS
Mri1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
cM Map840.74UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1195
Count of miRNA genes:589
Interacting mature miRNAs:718
Transcripts:ENSMUST00000005122, ENSMUST00000125498, ENSMUST00000126435, ENSMUST00000127747, ENSMUST00000140850
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000005122   ⟹   ENSMUSP00000005122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,253,931 - 84,257,247 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125498   ⟹   ENSMUSP00000117115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,251,022 - 84,256,413 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126435   ⟹   ENSMUSP00000122623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,249,906 - 84,257,324 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127747
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,255,792 - 84,257,326 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140850
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,254,245 - 84,257,326 (-)Ensembl
RefSeq Acc Id: NM_026423   ⟹   NP_080699
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,977,205 - 84,983,953 (-)NCBI
GRCm38884,250,576 - 84,257,324 (-)NCBI
MGSCv37886,774,475 - 86,781,223 (-)RGD
Celera888,552,772 - 88,559,465 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080699   ⟸   NM_026423
- UniProtKB: Q9CQT1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117115   ⟸   ENSMUST00000125498
RefSeq Acc Id: ENSMUSP00000122623   ⟸   ENSMUST00000126435
RefSeq Acc Id: ENSMUSP00000005122   ⟸   ENSMUST00000005122

Promoters
RGD ID:8667661
Promoter ID:EPDNEW_M11862
Type:initiation region
Name:Mri1_1
Description:Mus musculus methylthioribose-1-phosphate isomerase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,257,292 - 84,257,352EPDNEW
RGD ID:6843488
Promoter ID:MM_KWN:55064
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026423_MRI1,   OTTMUST00000081856,   OTTMUST00000081857,   OTTMUST00000081858,   OTTMUST00000081859
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,780,606 - 86,782,132 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915123 AgrOrtholog
Ensembl Genes ENSMUSG00000004996 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000005122 UniProtKB/TrEMBL
  ENSMUSP00000117115 UniProtKB/TrEMBL
  ENSMUSP00000122623 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005122 UniProtKB/TrEMBL
  ENSMUST00000125498 UniProtKB/TrEMBL
  ENSMUST00000126435 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF-2B-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF-M1Pi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_2B-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Initiation_fac_2B_a/b/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1Pi_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67873 UniProtKB/Swiss-Prot
MGD MGI:1915123 ENTREZGENE
NCBI Gene 67873 ENTREZGENE
Pfam IF-2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mri1 PhenoGen
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs eIF-2B_rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  salvage_mtnA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.278085 ENTREZGENE
UniProt F6YY88_MOUSE UniProtKB/TrEMBL
  F8WI95_MOUSE UniProtKB/TrEMBL
  MTNA_MOUSE UniProtKB/Swiss-Prot
  Q91VS5_MOUSE UniProtKB/TrEMBL
  Q9CQT1 ENTREZGENE
UniProt Secondary Q8BXF6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Mri1  methylthioribose-1-phosphate isomerase 1    methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED