Mri1 (methylthioribose-1-phosphate isomerase 1)

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Gene: Mri1 (methylthioribose-1-phosphate isomerase 1) Mus musculus

Analyze

Symbol:

Mri1

Name:

methylthioribose-1-phosphate isomerase 1

RGD ID:

1332408

MGI Page

MGI

Description:

Predicted to have S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to localize to cytosol; fibrillar center; and nucleoplasm. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; chromium(6+).

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

2410018C20Rik; M1Pi; methylthioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MRI1 (methylthioribose-1-phosphate isomerase 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Mri1 (methylthioribose-1-phosphate isomerase 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mri1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MRI1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MRI1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mri1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MRI1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MRI1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mri1 (methylthioribose-1-phosphate isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mri1 (methylthioribose-1-phosphate isomerase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	MRI1 (methylthioribose-1-phosphate isomerase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	mri1 (methylthioribose-1-phosphate isomerase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	CG11334	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	C01G10.9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	MRI1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	84,977,205 - 84,983,953 (-)	NCBI	GRCm39		mm39
GRCm38	8	84,250,576 - 84,257,324 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,249,906 - 84,257,326 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	86,774,475 - 86,781,223 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,140,011 - 87,147,431 (-)	NCBI			mm8
Celera	8	88,552,772 - 88,559,465 (-)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

neurodegenerative disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

5-aza-2'-deoxycytidine (ISO)

antirheumatic drug (ISO)

cadmium dichloride (ISO)

chromium(6+) (EXP)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

endosulfan (ISO)

flutamide (ISO)

folic acid (EXP)

nefazodone (ISO)

nickel sulfate (ISO)

ochratoxin A (ISO)

pentachlorophenol (EXP)

phenobarbital (EXP)

quercetin (ISO)

rotenone (ISO)

Soman (ISO)

sunitinib (ISO)

tetrachloroethene (EXP)

thioacetamide (ISO)

valproic acid (ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular amino acid biosynthetic process (IEA)

cellular biosynthetic process (IEA)

cellular metabolic process (IEA)

L-methionine salvage from methylthioadenosine (IBA)

methionine biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

fibrillar center (ISO)

nucleoplasm (ISO)

nucleus (IEA)

Molecular Function

identical protein binding (ISO)

isomerase activity (IEA)

protein binding (ISO)

S-methyl-5-thioribose-1-phosphate isomerase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

References

References - curated


1.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGD and Homologene mouse data transfer
3.	MGD data from the GO Consortium
4.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	Pipeline to import KEGG annotations from KEGG into RGD
6.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:12477932	PMID:14610273	PMID:14681479	PMID:15782199	PMID:16141072	PMID:16141073	PMID:20059953	PMID:21267068	PMID:21873635
PMID:30333137

Genomics

Comparative Map Data

Mri1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	84,977,205 - 84,983,953 (-)	NCBI	GRCm39		mm39
GRCm38	8	84,250,576 - 84,257,324 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,249,906 - 84,257,326 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	86,774,475 - 86,781,223 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,140,011 - 87,147,431 (-)	NCBI			mm8
Celera	8	88,552,772 - 88,559,465 (-)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI

MRI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	13,764,522 - 13,774,282 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	13,764,492 - 13,774,282 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	13,875,328 - 13,885,096 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	13,736,337 - 13,746,096 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	19	13,769,122 - 13,778,884 (+)	NCBI
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	13,447,016 - 13,456,733 (+)	NCBI		HuRef
CHM1_1	19	13,875,880 - 13,885,599 (+)	NCBI		CHM1_1

Mri1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	25,360,299 - 25,366,283 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	25,360,164 - 25,366,806 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	36,336,487 - 36,342,471 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	25,591,115 - 25,597,099 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	25,595,940 - 25,601,925 (+)	NCBI
Celera	19	23,456,210 - 23,462,198 (+)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

Mri1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	32,585,756 - 32,589,261 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	32,585,714 - 32,589,343 (+)	NCBI	ChiLan1.0	ChiLan1.0

MRI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	14,060,777 - 14,067,521 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	14,060,859 - 14,067,222 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	13,327,569 - 13,336,286 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MRI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	48,653,152 - 48,658,160 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	48,648,987 - 48,658,231 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Mri1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936659	2,526,274 - 2,532,878 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MRI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	65,348,004 - 65,354,919 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	65,348,609 - 65,354,892 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	65,675,853 - 65,682,136 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MRI1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	12,424,835 - 12,431,911 (+)	NCBI
ChlSab1.1 Ensembl	6	12,425,052 - 12,431,844 (+)	Ensembl

Mri1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624901	1,105,763 - 1,110,281 (+)	NCBI

Position Markers

RH118315

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	84,255,204 - 84,255,355	UniSTS	GRCm38
MGSCv37	8	86,779,103 - 86,779,254	UniSTS	GRCm37
Celera	8	88,557,341 - 88,557,492	UniSTS
Cytogenetic Map	8	C3	UniSTS
Whitehead/MRC_RH	8	998.98	UniSTS

RH126162

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	84,258,372 - 84,258,605	UniSTS	GRCm38
MGSCv37	8	86,782,271 - 86,782,504	UniSTS	GRCm37
Celera	8	88,560,508 - 88,560,741	UniSTS
Cytogenetic Map	8	C3	UniSTS
Whitehead/MRC_RH	8	1004.96	UniSTS

Mri1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	C3	UniSTS
cM Map	8	40.74	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71136783	90202598	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73202495	107202598	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	73400000	126100000	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	75675517	109675623	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
1301808	Nhdlq1_m	non-HDL QTL 1 (mouse)			Not determined		8	75685348	109685497	Mouse
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	75685348	109685497	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	78518613	112518703	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79082178	113082403	Mouse
12904012	Cfq10_m	conditioned fear QTL 10 (mouse)					8	80066775	89014359	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81092664	115092664	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	81619151	115619151	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1195
Count of miRNA genes:	589
Interacting mature miRNAs:	718
Transcripts:	ENSMUST00000005122, ENSMUST00000125498, ENSMUST00000126435, ENSMUST00000127747, ENSMUST00000140850
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_026423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC122794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK007709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK010538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK013882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK047287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK144807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK164635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK164894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK177142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK180146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK182796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK185486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC009164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000005122 ⟹ ENSMUSP00000005122

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,253,931 - 84,257,247 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000125498 ⟹ ENSMUSP00000117115

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,251,022 - 84,256,413 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000126435 ⟹ ENSMUSP00000122623

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,249,906 - 84,257,324 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000127747

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,255,792 - 84,257,326 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000140850

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,254,245 - 84,257,326 (-)	Ensembl

RefSeq Acc Id:

NM_026423 ⟹ NP_080699

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	84,977,205 - 84,983,953 (-)	NCBI
GRCm38	8	84,250,576 - 84,257,324 (-)	NCBI
MGSCv37	8	86,774,475 - 86,781,223 (-)	RGD
Celera	8	88,552,772 - 88,559,465 (-)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GGCAGGACGCAACTCCGCCCCGCAGCCTGTGCAGGATTCCTCGTGGCCCTGCAGGGTAGGCAAC
ATGACACTGGAAGCGATCCGCTACTCGCCCGGCTCGCTGCAGATCCTCGACCAGCTGCAGCTGC
CAGAGCACTGCCACTATGAGGCACTGAGCTCCGTGCAGCAGGCTAGTGAAGCCATCCGCGCCAT
GAAGGTGCGCGGAGCCCCGGCCATCGCGCTGGTCGGCTGCCTCAGCCTGGCCGTGGAGCTGCGG
GCCGGCGCCGGCGGTCCCGGACTCGCTGCTCTGGTGGCCTTCGTGCGAGACCAGCTGCGCCTCT
TAGTCGCCGCCCGGCCCACCGCTGTCAACATGGCCCGCGCCGCCCGCGATCTGGGTCAAGTGGC
AGCCCAGGAGGCGGAACGAGAGGGTGCCACTGAAGAGACCGTGCGGGAAAGAGTGATCCGCTTC
GCCGAGGATATGTTGGAGAAGGACCTCAAAGACAACCGGAGCATCGGGGACTTGGGAGCCCGCC
ATCTCCTAGAGCAGACCAACCCCAGGGGTGGCAAGGTGACCGTGCTGACCCACTGTAACACGGG
TGCTCTGGCCACTGCTGGCTATGGTACAGCGTTAGGTGTGATCCGCTCACTGCATGAGATGGGC
CGATTGGAGCATACCTTCTGCACAGAGACCCGGCCCTACAACCAGGGAGCCCGGCTGACGGCCT
TCGAGCTGGTGTACGAGCAGATCCCTGCAACTCTCATCACTGACAGCATGGCGGCGGCTGCCAT
GGCACACCGGGGTGTGTCAGCCGTGGTGGTGGGAGCTGACCGTGTTGTTGCCAATGGAGACACA
GCCAACAAAATAGGCACCTATCAGCTGGCCATTGTCGCCAAACACCACGGTGTCCCCTTCTATG
TGGCTGCCCCCAGTTCATCCTGTGACCTCCATCTGGAGACTGGAAAGGAGATTGTCATAGAGGA
ACGCCCCAGCCAGGAGCTAACTGACCTGAATGGAGTCAGGATTGCTGCACAGGGAATCCGGGTT
TGGAATCCTGCCTTTGATGTCACCCCCCACGAACTCATCACAGGTGGCATCATCACTGAACTGG
GTGTCTTTGCCCCTGAGGAGCTCCGAGGAGCCCTAAGTGCCTCCGTCTTCTCAGAGGGACAGAC
CCTAGATAGTCCCTGGGTGTGACTGGCTGGCCCTCCGTGCCCTGCCCTGACTTCCTCTGGTTTT
ATAATAAAGTTCTCAAATGGCTACCCAAAGTTCATCTTCACCCACACTCCCTCTTCCAGCTGCA
GGAACAGATATGGTTTGCCAGGTTCTGCAGAGTTTCAGCATCCACAGCAAAGCTGCCTAAGGTC
GCGTCCCAGGCTCATCCTTGGAATGATCTATGCATGGGATGAAAGACAGATGTGGCGGTCACAC
ACCTGTAATCTCAGCACCTGGGAGGCTCAGGCAGGAAGATTTGGAGTTTAGGCTACCCTGGGCT
ACAGATTCAAACAGACAAACAAAAGTAGAGATAATCAGGATGTTCTCTTAGTTACATTTGAATT
TTTTTGTTGTTGTTGATTCTATTTTGTTTTGTTTTGTTTTTTCTAGACAGGATTTTTCTGTGTC
TCCTTGGCTATCCTGGAACAATCTGTAGATCAGGCTGGCTTCAAACTCAGAGATCCTCCTGCCT
CTGTCTCCCAAGTGCTGGGATTAAATGCATGCACCACTACTGGCTATTTACTTTTATTTATGTG
TGAGTGTTTTACATGCAAACCCCTGGTGCTCTCCCAGACCAGAAAAGGGTACCAGATCTCCTGG
AACTGGAATTACAAGTGGTTGTGAGCTGCCATATGGGAGCTGGGACCCAGGAACTAAACCTCTG
TGCTAGAACAAGTCCTATAAAAGAAGACACCAAAGTTCAGTAATCAAGATAAATATTTGTGTTT
TAAGGCAGTCTCTTTGTAGCTCTGGCTGCCCTTGGACTTGCTCTATGGACCAGGCTACCCTAGA
ACTCACAAAGATCCACCTACCTCTGCCTCTTGAGCAAAAGGTCAAAAGTGTGAGCCCCTACAAC
CTGCTTTGCTTTATTCTTGAGAGTCTGTGAACCTGGAATTCAGCTATCAGGCTAGACTCCAGGG
GTCCTCCCGCTTCAGCCAACTTAGCACTGGGATAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_080699	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH09164	(Get FASTA)	NCBI Sequence Viewer
	AAH25049	(Get FASTA)	NCBI Sequence Viewer
	BAB27014	(Get FASTA)	NCBI Sequence Viewer
	BAB29034	(Get FASTA)	NCBI Sequence Viewer
	BAC33016	(Get FASTA)	NCBI Sequence Viewer
	BAE37957	(Get FASTA)	NCBI Sequence Viewer
	EDL10940	(Get FASTA)	NCBI Sequence Viewer
	EDL10941	(Get FASTA)	NCBI Sequence Viewer
	Q9CQT1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_080699 ⟸ NM_026423

- UniProtKB:

Q9CQT1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MTLEAIRYSPGSLQILDQLQLPEHCHYEALSSVQQASEAIRAMKVRGAPAIALVGCLSLAVELR
AGAGGPGLAALVAFVRDQLRLLVAARPTAVNMARAARDLGQVAAQEAEREGATEETVRERVIRF
AEDMLEKDLKDNRSIGDLGARHLLEQTNPRGGKVTVLTHCNTGALATAGYGTALGVIRSLHEMG
RLEHTFCTETRPYNQGARLTAFELVYEQIPATLITDSMAAAAMAHRGVSAVVVGADRVVANGDT
ANKIGTYQLAIVAKHHGVPFYVAAPSSSCDLHLETGKEIVIEERPSQELTDLNGVRIAAQGIRV
WNPAFDVTPHELITGGIITELGVFAPEELRGALSASVFSEGQTLDSPWV

hide sequence

RefSeq Acc Id:

ENSMUSP00000117115 ⟸ ENSMUST00000125498

RefSeq Acc Id:

ENSMUSP00000122623 ⟸ ENSMUST00000126435

RefSeq Acc Id:

ENSMUSP00000005122 ⟸ ENSMUST00000005122

Promoters

RGD ID:

8667661

Promoter ID:

EPDNEW_M11862

Type:

initiation region

Name:

Mri1_1

Description:

Mus musculus methylthioribose-1-phosphate isomerase 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	84,257,292 - 84,257,352	EPDNEW

RGD ID:

6843488

Promoter ID:

MM_KWN:55064

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_026423_MRI1, OTTMUST00000081856, OTTMUST00000081857, OTTMUST00000081858, OTTMUST00000081859

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	86,780,606 - 86,782,132 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1915123	AgrOrtholog
Ensembl Genes	ENSMUSG00000004996	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000005122	UniProtKB/TrEMBL
	ENSMUSP00000117115	UniProtKB/TrEMBL
	ENSMUSP00000122623	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000005122	UniProtKB/TrEMBL
	ENSMUST00000125498	UniProtKB/TrEMBL
	ENSMUST00000126435	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.420	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.10470	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	IF-2B-related	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF-M1Pi	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_2B-like_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Initiation_fac_2B_a/b/d	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	M1Pi_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NagB/RpiA_transferase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:67873	UniProtKB/Swiss-Prot
MGD	MGI:1915123	ENTREZGENE
NCBI Gene	67873	ENTREZGENE
Pfam	IF-2B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mri1	PhenoGen
Superfamily-SCOP	SSF100950	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	eIF-2B_rel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	salvage_mtnA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.278085	ENTREZGENE
UniProt	F6YY88_MOUSE	UniProtKB/TrEMBL
	F8WI95_MOUSE	UniProtKB/TrEMBL
	MTNA_MOUSE	UniProtKB/Swiss-Prot
	Q91VS5_MOUSE	UniProtKB/TrEMBL
	Q9CQT1	ENTREZGENE
UniProt Secondary	Q8BXF6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-29	Mri1	methylthioribose-1-phosphate isomerase 1		methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)