Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Demecolcine results in increased expression of PKIG mRNA | CTD | PMID:23649840 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PKIG mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKIG mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | PKIG (Homo sapiens) | 6480464 | Estradiol affects the expression of PKIG mRNA | CTD | PMID:22574217 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKIG mRNA and Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of PKIG mRNA] | CTD | PMID:15667827 and PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pkig (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PKIG mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PKIG mRNA | CTD | PMID:20702594 and PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PKIG mRNA | CTD | PMID:19465110 | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:20702594 | 5-aza-2'-deoxycytidine | affects expression | ISO | PKIG (Homo sapiens) | 6480464 | Decitabine affects the expression of PKIG mRNA | CTD | PMID:23300844 | aflatoxin B1 | affects expression | ISO | PKIG (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PKIG protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of PKIG mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PKIG mRNA | CTD | PMID:33167477 | antirheumatic drug | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PKIG mRNA | CTD | PMID:24449571 | arsenite(3-) | multiple interactions | ISO | PKIG (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to PKIG mRNA] | CTD | PMID:32406909 | benzene | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Benzene results in decreased expression of PKIG mRNA | CTD | PMID:15929907 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PKIG mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PKIG mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | PKIG (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PKIG 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | PKIG (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PKIG promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PKIG mRNA | CTD | PMID:27858113 | benzo[b]fluoranthene | increases expression | EXP | | 6480464 | benzo(b)fluoranthene results in increased expression of PKIG mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PKIG mRNA | CTD | PMID:27858113 | benzo[e]pyrene | decreases methylation | ISO | PKIG (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of PKIG intron | CTD | PMID:30157460 | bisphenol A | increases expression | ISO | Pkig (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PKIG mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PKIG mRNA | CTD | PMID:35598803 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in increased expression of PKIG mRNA | CTD | PMID:25554681 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PKIG gene | CTD | PMID:20938992 | chrysene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PKIG mRNA | CTD | PMID:27858113 | cisplatin | affects expression | ISO | PKIG (Homo sapiens) | 6480464 | Cisplatin affects the expression of PKIG mRNA | CTD | PMID:23300844 | cisplatin | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PKIG mRNA | CTD | PMID:27392435 | copper(II) sulfate | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PKIG mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PKIG mRNA | CTD | PMID:25562108 | dibenz[a,h]anthracene | increases expression | EXP | | 6480464 | 1 more ... | CTD | PMID:26377693 | dibutyl phthalate | increases expression | ISO | Pkig (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in increased expression of PKIG mRNA | CTD | PMID:21266533 | doxorubicin | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PKIG mRNA | CTD | PMID:29803840 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of PKIG mRNA | CTD | PMID:35436446 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PKIG gene | CTD | PMID:20938992 | formaldehyde | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PKIG mRNA | CTD | PMID:23649840 | isoflurane | decreases methylation | EXP | | 6480464 | Isoflurane results in decreased methylation of PKIG mRNA | CTD | PMID:35249202 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PKIG gene | CTD | PMID:20938992 | lipopolysaccharide | multiple interactions | ISO | PKIG (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PKIG mRNA | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of PKIG mRNA | CTD | PMID:35811015 | methapyrilene | decreases methylation | ISO | PKIG (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of PKIG intron | CTD | PMID:30157460 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | decreases expression | EXP | | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PKIG mRNA | CTD | PMID:25566086 | O-methyleugenol | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of PKIG mRNA | CTD | PMID:32234424 | oxaliplatin | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | oxaliplatin results in decreased expression of PKIG mRNA | CTD | PMID:17762391 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PKIG mRNA | CTD | PMID:17562736 | paracetamol | affects response to substance | ISO | PKIG (Homo sapiens) | 6480464 | PKIG gene polymorphism affects the susceptibility to Acetaminophen | CTD | PMID:26104854 | PCB138 | decreases expression | ISO | Pkig (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | pyrogallol | decreases expression | EXP | | 6480464 | Pyrogallol results in decreased expression of PKIG mRNA | CTD | PMID:20362636 | pyrogallol | multiple interactions | EXP | | 6480464 | Silymarin inhibits the reaction [Pyrogallol results in decreased expression of PKIG mRNA] | CTD | PMID:20362636 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PKIG (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PKIG mRNA | CTD | PMID:35811015 | silicon dioxide | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of PKIG mRNA | CTD | PMID:25351596 | sulforaphane | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of PKIG mRNA | CTD | PMID:31838189 | sunitinib | decreases expression | ISO | PKIG (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PKIG mRNA | CTD | PMID:31533062 | T-2 toxin | affects expression | ISO | Pkig (Rattus norvegicus) | 6480464 | T-2 Toxin affects the expression of PKIG protein | CTD | PMID:26141394 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PKIG mRNA | CTD | PMID:31919559 | tetraphene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PKIG mRNA | CTD | PMID:27858113 | valproic acid | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PKIG mRNA | CTD | PMID:28001369 and PMID:29154799 | vincristine | increases expression | ISO | PKIG (Homo sapiens) | 6480464 | Vincristine results in increased expression of PKIG mRNA | CTD | PMID:23649840 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 4. | Database resources of the National Center for Biotechnology Information. | Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6. |
Additional References at PubMed
| PMID:9218452 | PMID:10349636 | PMID:10512203 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11549321 | PMID:12466851 | PMID:12477932 | PMID:14610273 | PMID:15489334 |
| PMID:15557275 | PMID:15782199 | PMID:15840001 | PMID:16141072 | PMID:16141073 | PMID:16870489 | PMID:18287559 | PMID:18346943 | PMID:18799693 | PMID:18973680 | PMID:21267068 | PMID:21677750 |
| PMID:21873635 | PMID:22641646 | PMID:23604909 | PMID:23963683 | PMID:27626380 | PMID:28106071 | PMID:32325033 |
Genomics
Comparative Map Data
| Pkig (Mus musculus - house mouse) |
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| PKIG (Homo sapiens - human) |
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| Pkig (Rattus norvegicus - Norway rat) |
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| Pkig (Chinchilla lanigera - long-tailed chinchilla) |
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| PKIG (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PKIG (Canis lupus familiaris - dog) |
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| Pkig (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PKIG (Sus scrofa - pig) |
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| PKIG (Chlorocebus sabaeus - green monkey) |
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| Pkig (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Pkig
2048 total Variants 
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