Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | increases expression | EXP | | 6480464 | ethylene dichloride results in increased expression of EXOC3 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | affects expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of EXOC3 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of EXOC3 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of EXOC3 mRNA | CTD | PMID:16214954 and PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EXOC3 mRNA | CTD | PMID:18796159 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EXOC3 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EXOC3 mRNA and Tetrachlorodibenzodioxin results in increased expression of SEC6 mRNA | CTD | PMID:16054898 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EXOC3 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EXOC3 mRNA | CTD | PMID:20159946 | 2,4,6-tribromophenol | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,4-dinitrotoluene | affects expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of EXOC3 mRNA | CTD | PMID:21346803 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | 3 more ... | CTD | PMID:20959002 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of EXOC3 protein | CTD | PMID:31675489 | 3-chloropropane-1,2-diol | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | alpha-Chlorohydrin results in increased expression of EXOC3 protein | CTD | PMID:34915118 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EXOC3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of EXOC3 mRNA | CTD | PMID:28628672 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of EXOC3 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of EXOC3 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of EXOC3 mRNA | CTD | PMID:28628672 | acrolein | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EXOC3 mRNA | CTD | PMID:32699268 | acrylamide | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of EXOC3 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of EXOC3 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EXOC3 mRNA | CTD | PMID:15498508 and PMID:33167477 | allethrin | multiple interactions | ISO | Exoc3 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EXOC3 protein | CTD | PMID:34896426 | alpha-pinene | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EXOC3 mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of EXOC3 mRNA | CTD | PMID:16483693 | Aroclor 1254 | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of EXOC3 mRNA | CTD | PMID:18178546 | arsane | affects methylation | ISO | EXOC3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EXOC3 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | EXOC3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EXOC3 gene | CTD | PMID:25304211 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of EXOC3 mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | increases methylation | ISO | EXOC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EXOC3 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | EXOC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of EXOC3 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EXOC3 mRNA | CTD | PMID:26063408 | bisphenol A | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EXOC3 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EXOC3 protein | CTD | PMID:31675489 | bisphenol A | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of EXOC3 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol F | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EXOC3 mRNA | CTD | PMID:28628672 | butan-1-ol | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of EXOC3 mRNA | CTD | PMID:29432896 | cadmium atom | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Cadmium results in increased expression of EXOC3 mRNA | CTD | PMID:24376830 | caffeine | decreases phosphorylation | ISO | EXOC3 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of EXOC3 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of EXOC3 mRNA | CTD | PMID:37019170 | cisplatin | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of EXOC3 mRNA | CTD | PMID:21858171 | copper atom | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of EXOC3 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of EXOC3 mRNA | CTD | PMID:20971185 | cyhalothrin | multiple interactions | ISO | Exoc3 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EXOC3 protein | CTD | PMID:34896426 | cypermethrin | multiple interactions | ISO | Exoc3 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EXOC3 protein | CTD | PMID:34896426 | dexamethasone | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EXOC3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of EXOC3 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of EXOC3 mRNA | CTD | PMID:21266533 | diuron | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Diuron results in increased expression of EXOC3 mRNA | CTD | PMID:21551480 | elemental selenium | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SEC6 mRNA | CTD | PMID:19244175 | ethanol | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of EXOC3 mRNA | CTD | PMID:29432896 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of EXOC3 mRNA | CTD | PMID:30319688 | fenvalerate | multiple interactions | ISO | Exoc3 (Rattus norvegicus) | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of EXOC3 protein | CTD | PMID:34896426 | finasteride | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of EXOC3 mRNA | CTD | PMID:24136188 | flutamide | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of EXOC3 mRNA | CTD | PMID:24136188 | formaldehyde | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of EXOC3 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EXOC3 gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Gentamicins results in increased expression of EXOC3 mRNA | CTD | PMID:29992668 | gentamycin | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of EXOC3 mRNA | CTD | PMID:33387578 | indometacin | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EXOC3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of EXOC3 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EXOC3 protein | CTD | PMID:32959892 | leflunomide | increases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | leflunomide results in increased expression of EXOC3 mRNA | CTD | PMID:24136188 | methyl methanesulfonate | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of EXOC3 mRNA | CTD | PMID:23649840 | Nor-9-carboxy-delta9-THC | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of EXOC3 gene | CTD | PMID:30521419 | ozone | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC3 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | phenylmercury acetate | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of EXOC3 mRNA | CTD | PMID:26272509 | piroxicam | multiple interactions | ISO | EXOC3 (Homo sapiens) | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of EXOC3 mRNA | CTD | PMID:21858171 | potassium dichromate | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of EXOC3 protein | CTD | PMID:23718831 | pyrethrins | decreases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Pyrethrins results in decreased expression of EXOC3 protein | CTD | PMID:34896426 | selenium atom | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SEC6 mRNA | CTD | PMID:19244175 | sodium arsenite | decreases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of EXOC3 protein | CTD | PMID:30528433 | sulindac | decreases expression | ISO | Exoc3 (Rattus norvegicus) | 6480464 | Sulindac results in decreased expression of EXOC3 mRNA | CTD | PMID:24136188 | tamibarotene | affects expression | ISO | EXOC3 (Homo sapiens) | 6480464 | tamibarotene affects the expression of EXOC3 mRNA | CTD | PMID:15498508 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of EXOC3 mRNA | CTD | PMID:30912803 | vinclozolin | increases methylation | ISO | Exoc3 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of EXOC3 gene | CTD | PMID:31079544 | vitamin E | increases expression | ISO | EXOC3 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SEC6 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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Imported Annotations - PID (archival)
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Mammalian Phenotype
Disease Annotations
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 5. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 7. | Database resources of the National Center for Biotechnology Information. | Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6. |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10925150 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12477932 | PMID:14610273 | PMID:15449545 | PMID:15782199 | PMID:15878854 | PMID:16141072 |
| PMID:16141073 | PMID:21873635 | PMID:22420621 | PMID:32325033 | PMID:33560379 |
Genomics
Comparative Map Data
| Exoc3 (Mus musculus - house mouse) |
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| EXOC3 (Homo sapiens - human) |
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| Exoc3 (Rattus norvegicus - Norway rat) |
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| Exoc3 (Chinchilla lanigera - long-tailed chinchilla) |
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| EXOC3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| EXOC3 (Canis lupus familiaris - dog) |
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| Exoc3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| EXOC3 (Sus scrofa - pig) |
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| EXOC3 (Chlorocebus sabaeus - green monkey) |
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| Exoc3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Exoc3
1513 total Variants 
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