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Gene: Xrn1 (5'-3' exoribonuclease 1) Mus musculus
Symbol: Xrn1
Name: 5'-3' exoribonuclease 1
Description: ENCODES a protein that exhibits 5'-3' exoribonuclease activity; G-quadruplex DNA binding; G-quadruplex RNA binding; INVOLVED IN RNA phosphodiester bond hydrolysis, exonucleolytic; histone mRNA catabolic process (ortholog); negative regulation of translation (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Staphylococcal Infections (ortholog); FOUND IN cytoplasm; P-body; cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; choline
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dhm2; exo; mXrn1; strand-exchange protein 1 homolog
Homo sapiens (human) : XRN1 (5'-3' exoribonuclease 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrn1 (5'-3' exoribonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrn1 (5'-3' exoribonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XRN1 (5'-3' exoribonuclease 1)
Canis lupus familiaris (dog) : XRN1 (5'-3' exoribonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrn1 (5'-3' exoribonuclease 1)
Sus scrofa (pig) : XRN1 (5'-3' exoribonuclease 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38995,954,750 - 96,057,806 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37995,855,179 - 95,953,453 (+)NCBIGRCm37mm9NCBIm37
MGSCv36995,764,221 - 95,861,980 (+)NCBImm8
Celera995,521,247 - 95,619,349 (+)NCBICelera
Cytogenetic Map9 E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Xrn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332329
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.