Adnp2 (ADNP homeobox 2) - Rat Genome Database
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Gene: Adnp2 (ADNP homeobox 2) Mus musculus
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Symbol: Adnp2
Name: ADNP homeobox 2
RGD ID: 1332284
MGI Page MGI
Description: Predicted to have DNA binding activity and metal ion binding activity. Involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to localize to nucleus. Is expressed in several structures, including blastocyst; brain; genitourinary system; pancreas; and retina nuclear layer. Orthologous to human ADNP2 (ADNP homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 8430420L05Rik; activity-dependent neuroprotector homeobox protein 2; ADNP homeobox protein 2; BC024969; Kiaa0863; MGC38953; mKIAA0863; RIKEN cDNA 8430420L05 gene; Zfp50; Zfp508; zinc finger protein 508
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm16270   Gm17896  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,169,523 - 80,195,284 (-)NCBIGRCm39mm39
GRCm381880,126,315 - 80,151,516 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,126,311 - 80,151,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,323,874 - 80,348,221 (-)NCBIGRCm37mm9NCBIm37
MGSCv361880,287,794 - 80,313,822 (-)NCBImm8
Celera1881,246,577 - 81,270,977 (-)NCBICelera
Cytogenetic Map18E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12465718   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15226823  
PMID:15489334   PMID:15618518   PMID:16141072   PMID:16141073   PMID:16325481   PMID:17967808   PMID:18179478   PMID:18287559   PMID:18799693   PMID:21267068   PMID:21873635   PMID:24952961  
PMID:31315048  


Genomics

Comparative Map Data
Adnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391880,169,523 - 80,195,284 (-)NCBIGRCm39mm39
GRCm381880,126,315 - 80,151,516 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1880,126,311 - 80,151,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv371880,323,874 - 80,348,221 (-)NCBIGRCm37mm9NCBIm37
MGSCv361880,287,794 - 80,313,822 (-)NCBImm8
Celera1881,246,577 - 81,270,977 (-)NCBICelera
Cytogenetic Map18E3NCBI
ADNP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1880,109,262 - 80,147,523 (+)EnsemblGRCh38hg38GRCh38
GRCh381880,109,251 - 80,140,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371877,866,915 - 77,898,229 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361875,967,903 - 75,999,220 (+)NCBINCBI36hg18NCBI36
Celera1874,639,542 - 74,670,861 (+)NCBI
Cytogenetic Map18q23NCBI
HuRef1874,488,684 - 74,519,969 (+)NCBIHuRef
CHM1_11877,861,922 - 77,893,235 (+)NCBICHM1_1
Adnp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01876,637,415 - 76,661,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1876,637,785 - 76,653,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01872,145,550 - 72,169,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41877,017,502 - 77,041,570 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11877,090,698 - 77,114,104 (-)NCBI
Celera1872,235,432 - 72,259,493 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
Adnp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540263,311,741 - 63,347,641 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540263,312,588 - 63,346,307 (+)NCBIChiLan1.0ChiLan1.0
ADNP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11877,080,446 - 77,103,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1877,080,441 - 77,103,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01873,757,926 - 73,789,771 (+)NCBIMhudiblu_PPA_v0panPan3
ADNP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1602,264 - 635,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11600,804 - 635,013 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adnp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936616124,590 - 145,944 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADNP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6128,030,715 - 128,113,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16128,071,503 - 128,113,292 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21310,003,280 - 310,043,658 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADNP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118140,780 - 169,416 (-)NCBI
ChlSab1.1 Ensembl18139,995 - 169,052 (-)Ensembl
Adnp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624806191,927 - 225,321 (-)NCBI

Position Markers
AW212659  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,127,349 - 80,127,451UniSTSGRCm38
MGSCv371880,324,088 - 80,324,190UniSTSGRCm37
Celera1881,246,791 - 81,246,893UniSTS
Cytogenetic Map18E3UniSTS
Whitehead/MRC_RH18968.58UniSTS
D18Mit129  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,132,049 - 80,132,186UniSTSGRCm38
MGSCv371880,328,788 - 80,328,925UniSTSGRCm37
Celera1881,251,544 - 81,251,681UniSTS
Cytogenetic Map18E3UniSTS
cM Map1855.0UniSTS
Whitehead Genetic1837.2UniSTS
Whitehead_YAC18 UniSTS
UniSTS:237853  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381880,127,444 - 80,127,578UniSTSGRCm38
MGSCv371880,324,183 - 80,324,317UniSTSGRCm37
Celera1881,246,886 - 81,247,020UniSTS
Cytogenetic Map18E3UniSTS
Adnp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E3UniSTS
cM Map18 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184629021680290216Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184674183280741971Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184674183280741971Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185091908584919240Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185091908584919240Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185153522985535397Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185153522985535397Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185267220586672345Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185484280185496018Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185630000090300000Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185630000090300000Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185730000090702639Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185742926790702639Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5745748782586603Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5785721090702639Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185904702190702639Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185904702190702639Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185904702190702639Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185982648990702639Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185984762690702639Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186113937681448616Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186113937682586603Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186712626490702639Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186967220585496018Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187155126490702639Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187261252384126470Mouse
4142153Idd21.1_minsulin dependent diabetes susceptibility 21.1 (mouse)Not determined187442926784126470Mouse
4141757Sicd1_mseizure-induced cell death 1 (mouse)Not determined188013204989572790Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:249
Interacting mature miRNAs:263
Transcripts:ENSMUST00000066743
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066743   ⟹   ENSMUSP00000068560
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1880,126,311 - 80,151,482 (-)Ensembl
RefSeq Acc Id: NM_175028   ⟹   NP_778193
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,170,350 - 80,194,697 (-)NCBI
GRCm381880,127,135 - 80,151,482 (-)NCBI
MGSCv371880,323,874 - 80,348,221 (-)RGD
Celera1881,246,577 - 81,270,977 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526466   ⟹   XP_006526529
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,169,523 - 80,195,284 (-)NCBI
GRCm381880,126,315 - 80,151,516 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161143   ⟹   XP_036017036
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391880,169,523 - 80,185,931 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_778193   ⟸   NM_175028
- UniProtKB: Q8CHC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526529   ⟸   XM_006526466
- Peptide Label: isoform X1
- UniProtKB: Q8CHC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000068560   ⟸   ENSMUST00000066743
RefSeq Acc Id: XP_036017036   ⟸   XM_036161143
- Peptide Label: isoform X2

Promoters
RGD ID:13678242
Promoter ID:EPDNEW_M23270
Type:initiation region
Name:Adnp2_1
Description:Mus musculus ADNP homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381880,151,477 - 80,151,537EPDNEW
RGD ID:6829032
Promoter ID:MM_KWN:25803
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_175028
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361880,347,976 - 80,348,887 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448562 AgrOrtholog
Ensembl Genes ENSMUSG00000053950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000068560 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000066743 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ADNP/ADNP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:240442 UniProtKB/Swiss-Prot
MGD MGI:2448562 ENTREZGENE
NCBI Gene 240442 ENTREZGENE
PANTHER PTHR15740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adnp2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniGene Mm.26594 ENTREZGENE
UniProt ADNP2_MOUSE UniProtKB/Swiss-Prot
  Q3TV82_MOUSE UniProtKB/TrEMBL
  Q8CHC8 ENTREZGENE
UniProt Secondary Q6P294 UniProtKB/Swiss-Prot
  Q80VS0 UniProtKB/Swiss-Prot
  Q811H5 UniProtKB/Swiss-Prot
  Q8R1A2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Adnp2  ADNP homeobox 2  8430420L05Rik  RIKEN cDNA 8430420L05 gene  Data Merged 737654 PROVISIONAL