Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of AFTPH mRNA | CTD | PMID:22206623 | 1-nitropyrene | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | 1-nitropyrene results in increased expression of AFTPH mRNA | CTD | PMID:19041380 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AFTPH mRNA | CTD | PMID:19465110 and PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AFTPH mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of AFTPH mRNA | CTD | PMID:21570461 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of AFTPH mRNA | CTD | PMID:20188158 and PMID:26251327 | 3-chloropropane-1,2-diol | increases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | alpha-Chlorohydrin results in increased expression of AFTPH protein | CTD | PMID:34915118 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AFTPH mRNA | CTD | PMID:28628672 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of AFTPH mRNA | CTD | PMID:19162173 | aflatoxin B1 | decreases methylation | ISO | AFTPH (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of AFTPH gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Tretinoin results in increased expression of AFTPH mRNA | CTD | PMID:23724009 and PMID:33167477 | antirheumatic drug | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of AFTPH mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of AFTPH mRNA | CTD | PMID:33212167 | arsenous acid | decreases response to substance | ISO | AFTPH (Homo sapiens) | 6480464 | AFTPH protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | arsenous acid | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of AFTPH mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of AFTPH mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases methylation | ISO | AFTPH (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of AFTPH 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | increases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of AFTPH mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | AFTPH (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of AFTPH gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of AFTPH gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of AFTPH mRNA | CTD | PMID:34947998 | bisphenol F | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of AFTPH gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AFTPH mRNA | CTD | PMID:28628672 and PMID:31601247 | Brodifacoum | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | bromfenacoum results in decreased expression of AFTPH protein | CTD | PMID:28903499 | caffeine | affects phosphorylation | ISO | AFTPH (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of AFTPH protein | CTD | PMID:35688186 | cannabidiol | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Cannabidiol results in increased expression of AFTPH mRNA | CTD | PMID:27918106 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon results in decreased expression of AFTPH mRNA | CTD | PMID:25554681 | casticin | decreases expression | EXP | | 6480464 | casticin results in decreased expression of AFTPH mRNA | CTD | PMID:28444820 | cefaloridine | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | Cephaloridine results in decreased expression of AFTPH mRNA | CTD | PMID:18500788 | copper(II) sulfate | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of AFTPH mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | AFTPH (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of AFTPH protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of AFTPH mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AFTPH mRNA | CTD | PMID:28628672 | diarsenic trioxide | decreases response to substance | ISO | AFTPH (Homo sapiens) | 6480464 | AFTPH protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | diarsenic trioxide | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of AFTPH mRNA | CTD | PMID:20458559 | dicrotophos | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of AFTPH mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of AFTPH mRNA | CTD | PMID:29803840 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of AFTPH mRNA | CTD | PMID:30319688 | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of AFTPH mRNA | CTD | PMID:34813904 | fluoranthene | multiple interactions | EXP | | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of AFTPH mRNA | CTD | PMID:28329830 | flutamide | increases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of AFTPH mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of AFTPH mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | AFTPH (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of AFTPH protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of AFTPH gene and [bisphenol F co-treated with Fulvestrant] results in increased methylation of AFTPH gene | CTD | PMID:31601247 | gentamycin | decreases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of AFTPH mRNA | CTD | PMID:33387578 | hydrogen peroxide | affects expression | ISO | AFTPH (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of AFTPH mRNA | CTD | PMID:20044591 | indometacin | multiple interactions | ISO | AFTPH (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AFTPH mRNA | CTD | PMID:28628672 | lead(0) | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Lead results in decreased expression of AFTPH mRNA | CTD | PMID:19921347 | methylmercury chloride | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of AFTPH mRNA | CTD | PMID:28001369 | oxaliplatin | multiple interactions | ISO | Aftph (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of AFTPH mRNA | CTD | PMID:25729387 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of AFTPH mRNA | CTD | PMID:23892564 | resveratrol | decreases expression | ISO | AFTPH (Homo sapiens) | 6480464 | resveratrol results in decreased expression of AFTPH mRNA | CTD | PMID:25888808 | sunitinib | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Sunitinib results in increased expression of AFTPH mRNA | CTD | PMID:31533062 | thioacetamide | increases expression | ISO | Aftph (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of AFTPH mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | ISO | Aftph (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of AFTPH mRNA | CTD | PMID:25729387 | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of AFTPH mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | AFTPH (Homo sapiens) | 6480464 | Valproic Acid affects the expression of AFTPH mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | AFTPH (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of AFTPH mRNA | CTD | PMID:29154799 | |