Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) - Rat Genome Database

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Gene: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) Mus musculus
Analyze
Symbol: Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
RGD ID: 1332170
MGI Page MGI
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in several processes, including GCN2-mediated signaling; learning or memory; and regulation of translational initiation in response to stress. Localizes to intracellular anatomical structure and polysome. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and ovary. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610011M03; eIF-2-alpha kinase GCN2; eukaryotic translation initiation factor 2-alpha kinase 4; GCN; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; MGCN2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,219,065 - 118,305,715 (+)NCBIGRCm39mm39
GRCm39 Ensembl2118,219,099 - 118,305,715 (+)Ensembl
GRCm382118,388,583 - 118,475,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,214,353 - 118,300,970 (+)NCBIGRCm37mm9NCBIm37
MGSCv362118,080,058 - 118,166,674 (+)NCBImm8
Celera2119,539,566 - 119,626,375 (+)NCBICelera
Cytogenetic Map2E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
cell differentiation  (IEA)
cellular response to amino acid starvation  (IDA,IMP,ISO)
cellular response to cold  (ISO)
cellular response to leucine starvation  (IDA)
cellular response to starvation  (IDA)
cellular response to UV  (IDA)
defense response to virus  (IEA)
DNA damage checkpoint signaling  (IEA)
eiF2alpha phosphorylation in response to endoplasmic reticulum stress  (ISO)
endoplasmic reticulum unfolded protein response  (IMP)
GCN2-mediated signaling  (IDA,IMP,ISO)
immune system process  (IEA)
induction by virus of host autophagy  (IMP)
learning  (IMP)
long-term memory  (IMP)
negative regulation by host of viral genome replication  (IDA)
negative regulation of CREB transcription factor activity  (IMP)
negative regulation of neuron differentiation  (IMP)
negative regulation of translation  (IGI)
negative regulation of translational initiation  (IDA)
negative regulation of translational initiation in response to stress  (IDA)
nervous system development  (IEA)
neuron projection extension  (IMP)
phosphorylation  (IEA)
positive regulation of adaptive immune response  (IMP)
positive regulation of defense response to virus by host  (IDA)
positive regulation of gene expression  (IMP)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of translational initiation in response to starvation  (IDA,IMP)
protein autophosphorylation  (IDA)
protein phosphorylation  (IBA,IDA,IMP)
regulation of cell cycle  (IEA)
regulation of feeding behavior  (IMP)
regulation of translation  (IEA)
regulation of translational initiation  (ISS)
regulation of translational initiation by eIF2 alpha phosphorylation  (IDA,IGI,IMP,ISO)
regulation of translational initiation in response to stress  (IDA)
response to endoplasmic reticulum stress  (IGI)
T cell activation involved in immune response  (IMP)
viral process  (IEA)
viral translation  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1739968   PMID:8889548   PMID:10349636   PMID:10504407   PMID:10655230   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11106749   PMID:11389192   PMID:11544199   PMID:12176355  
PMID:12215525   PMID:12477932   PMID:12520002   PMID:12667446   PMID:14610273   PMID:14621295   PMID:14729979   PMID:15213227   PMID:15273307   PMID:15489334   PMID:15761153   PMID:15774759  
PMID:15894280   PMID:15937339   PMID:16054071   PMID:16121183   PMID:16141072   PMID:16141073   PMID:16176978   PMID:16601681   PMID:16709834   PMID:17141628   PMID:17276353   PMID:17343295  
PMID:17475769   PMID:17710230   PMID:18228065   PMID:18287093   PMID:18677106   PMID:18706471   PMID:18996085   PMID:19120448   PMID:19366986   PMID:19499519   PMID:19509078   PMID:19567830  
PMID:19586904   PMID:19635913   PMID:19783659   PMID:19828695   PMID:20072654   PMID:20473272   PMID:20559319   PMID:20660158   PMID:20807889   PMID:20861212   PMID:20924113   PMID:21076179  
PMID:21145762   PMID:21203563   PMID:21239484   PMID:21282364   PMID:21614613   PMID:21638082   PMID:21867687   PMID:21873635   PMID:21880833   PMID:22020073   PMID:22114338   PMID:22277968  
PMID:22491413   PMID:22509023   PMID:22517796   PMID:23318883   PMID:23356852   PMID:23443666   PMID:23447528   PMID:23775766   PMID:23900421   PMID:24002574   PMID:24019515   PMID:24130737  
PMID:24130751   PMID:24146979   PMID:24166753   PMID:24248597   PMID:24310610   PMID:24333428   PMID:24362236   PMID:24485657   PMID:24719324   PMID:25131199   PMID:25133427   PMID:25157170  
PMID:25329545   PMID:25406192   PMID:25491724   PMID:25562323   PMID:25857264   PMID:26082174   PMID:26102367   PMID:26123823   PMID:26261340   PMID:26526991   PMID:26936965   PMID:26968207  
PMID:26982722   PMID:27085088   PMID:27103515   PMID:27106802   PMID:27297692   PMID:27396336   PMID:27397084   PMID:27558825   PMID:27613409   PMID:27633668   PMID:27698114   PMID:27852836  
PMID:27880901   PMID:28242759   PMID:29337352   PMID:29449374   PMID:29570992   PMID:29660505   PMID:29742431   PMID:30006154   PMID:30120269   PMID:31121187   PMID:31166980   PMID:31194856  
PMID:31255283   PMID:31522764   PMID:31573843   PMID:31653831   PMID:31749445   PMID:31789450   PMID:31844909   PMID:31875620   PMID:32253314   PMID:32324833   PMID:32329716   PMID:32376799  
PMID:32504036   PMID:32853550   PMID:33186095  


Genomics

Comparative Map Data
Eif2ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,219,065 - 118,305,715 (+)NCBIGRCm39mm39
GRCm39 Ensembl2118,219,099 - 118,305,715 (+)Ensembl
GRCm382118,388,583 - 118,475,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,214,353 - 118,300,970 (+)NCBIGRCm37mm9NCBIm37
MGSCv362118,080,058 - 118,166,674 (+)NCBImm8
Celera2119,539,566 - 119,626,375 (+)NCBICelera
Cytogenetic Map2E5NCBI
EIF2AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1539,934,115 - 40,035,591 (+)EnsemblGRCh38hg38GRCh38
GRCh381539,934,115 - 40,035,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371540,226,316 - 40,327,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,013,639 - 38,115,089 (+)NCBINCBI36hg18NCBI36
Build 341538,033,406 - 38,115,083NCBI
Celera1516,989,625 - 17,091,096 (+)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1517,070,557 - 17,171,948 (+)NCBIHuRef
CHM1_11540,345,953 - 40,447,471 (+)NCBICHM1_1
Eif2ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,356,261 - 105,441,630 (+)NCBI
Rnor_6.0 Ensembl3110,159,708 - 110,249,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03110,159,624 - 110,245,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03116,705,333 - 116,791,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,870,871 - 104,875,529 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13104,716,669 - 104,802,714 (+)NCBI
Celera3104,273,489 - 104,358,836 (+)NCBICelera
Cytogenetic Map3q35NCBI
Eif2ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,897,848 - 7,009,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,897,897 - 7,005,602 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11537,128,000 - 37,229,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,120,044 - 37,229,211 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01518,871,867 - 18,973,380 (+)NCBIMhudiblu_PPA_v0panPan3
EIF2AK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,144,727 - 7,248,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,144,570 - 7,248,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,199,521 - 7,302,773 (+)NCBI
ROS_Cfam_1.0307,271,731 - 7,376,532 (+)NCBI
UMICH_Zoey_3.1307,195,772 - 7,298,966 (+)NCBI
UNSW_CanFamBas_1.0307,301,246 - 7,405,146 (+)NCBI
UU_Cfam_GSD_1.0307,430,444 - 7,533,631 (+)NCBI
Eif2ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,575,724 - 85,679,028 (+)NCBI
SpeTri2.0NW_0049364713,423,792 - 3,527,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,245,463 - 131,355,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,244,818 - 131,355,240 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,476,415 - 146,493,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,966,095 - 43,072,083 (-)NCBI
ChlSab1.1 Ensembl2642,962,447 - 43,072,001 (-)Ensembl
Eif2ak4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBI

Position Markers
D2Mit276  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,442,067 - 118,442,203UniSTSGRCm38
MGSCv372118,267,803 - 118,267,939UniSTSGRCm37
Celera2119,593,086 - 119,593,218UniSTS
Cytogenetic Map2E5UniSTS
cM Map265.0UniSTS
Whitehead Genetic254.6UniSTS
Whitehead/MRC_RH21506.08UniSTS
Whitehead_YAC2 UniSTS
PMC134046P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,430,424 - 118,431,330UniSTSGRCm38
MGSCv372118,256,160 - 118,257,066UniSTSGRCm37
Celera2119,581,377 - 119,582,283UniSTS
Cytogenetic Map2E5UniSTS
AI447567  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382118,449,832 - 118,449,969UniSTSGRCm38
MGSCv372118,275,568 - 118,275,705UniSTSGRCm37
Celera2119,601,074 - 119,601,211UniSTS
Cytogenetic Map2E5UniSTS
Whitehead/MRC_RH21506.08UniSTS
Eif2ak4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E5UniSTS
Cytogenetic Map2E5UniSTS
cM Map2 UniSTS
Eif2ak4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E5UniSTS
Eif2ak4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E5UniSTS
cM Map2 UniSTS
Eif2ak4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E5UniSTS
Eif2ak4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286265371120265478Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286265371120265478Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286265371120265478Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286265371120265478Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287610298121610433Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288184658122184825Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88313078122313225Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291259629125259759Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292948120126948262Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103265371129371085Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112194642128331901Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112194642128331901Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
13506762Tbvq2_mtrabecular bone volume QTL 2 (mouse)2115600000124900000Mouse
1558825Aabpr_maberrant activation of B cell proliferation (mouse)Not determined2116202748122377053Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:873
Count of miRNA genes:429
Interacting mature miRNAs:490
Transcripts:ENSMUST00000005233, ENSMUST00000102527, ENSMUST00000110869, ENSMUST00000110870, ENSMUST00000110872, ENSMUST00000110874, ENSMUST00000110877, ENSMUST00000125281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001355383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006499627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017318909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF193342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF193343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF193344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI324072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI643894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF453236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF462783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG086385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM250244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB723221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF748039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN527645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO430666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W75391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000005233   ⟹   ENSMUSP00000005233
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000102527   ⟹   ENSMUSP00000099586
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,389,112 - 118,475,231 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110869   ⟹   ENSMUSP00000106493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,438,842 - 118,452,290 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110870   ⟹   ENSMUSP00000106494
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,412,346 - 118,475,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110872   ⟹   ENSMUSP00000106496
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,389,112 - 118,475,232 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110874   ⟹   ENSMUSP00000106498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,388,847 - 118,475,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110877   ⟹   ENSMUSP00000106501
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,388,618 - 118,428,213 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2118,457,160 - 118,462,094 (+)Ensembl
RefSeq Acc Id: NM_001177806   ⟹   NP_001171277
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,593 - 118,305,715 (+)NCBI
GRCm382118,389,112 - 118,475,234 (+)NCBI
MGSCv372118,214,353 - 118,300,970 (+)RGD
Celera2119,539,566 - 119,626,375 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001355383   ⟹   NP_001342312
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,098 - 118,305,715 (+)NCBI
GRCm382118,388,617 - 118,475,234 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013719   ⟹   NP_038747
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,098 - 118,305,715 (+)NCBI
GRCm382118,388,617 - 118,475,234 (+)NCBI
MGSCv372118,214,353 - 118,300,970 (+)RGD
Celera2119,539,566 - 119,626,375 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499625   ⟹   XP_006499688
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,066 - 118,305,715 (+)NCBI
GRCm382118,388,584 - 118,475,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006499626   ⟹   XP_006499689
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,066 - 118,305,715 (+)NCBI
GRCm382118,388,584 - 118,475,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006499627   ⟹   XP_006499690
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,066 - 118,305,715 (+)NCBI
GRCm382118,388,584 - 118,475,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017318909   ⟹   XP_017174398
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,065 - 118,305,715 (+)NCBI
GRCm382118,388,583 - 118,475,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162252   ⟹   XP_036018145
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392118,219,065 - 118,305,715 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_038747   ⟸   NM_013719
- Peptide Label: isoform 1
- UniProtKB: Q9QZ05 (UniProtKB/Swiss-Prot),   A2AUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171277   ⟸   NM_001177806
- Peptide Label: isoform 2
- UniProtKB: Q9QZ05 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499688   ⟸   XM_006499625
- Peptide Label: isoform X3
- UniProtKB: Q9QZ05 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499689   ⟸   XM_006499626
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006499690   ⟸   XM_006499627
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017174398   ⟸   XM_017318909
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001342312   ⟸   NM_001355383
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000106493   ⟸   ENSMUST00000110869
RefSeq Acc Id: ENSMUSP00000106494   ⟸   ENSMUST00000110870
RefSeq Acc Id: ENSMUSP00000106501   ⟸   ENSMUST00000110877
RefSeq Acc Id: ENSMUSP00000106496   ⟸   ENSMUST00000110872
RefSeq Acc Id: ENSMUSP00000106498   ⟸   ENSMUST00000110874
RefSeq Acc Id: ENSMUSP00000005233   ⟸   ENSMUST00000005233
RefSeq Acc Id: ENSMUSP00000099586   ⟸   ENSMUST00000102527
RefSeq Acc Id: XP_036018145   ⟸   XM_036162252
- Peptide Label: isoform X2
Protein Domains
Protein kinase   RWD

Promoters
RGD ID:6831236
Promoter ID:MM_KWN:31161
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000102527,   ENSMUST00000110874,   OTTMUST00000036076,   UC008LRV.1,   UC008LRX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362118,214,166 - 118,214,666 (+)MPROMDB
RGD ID:6847647
Promoter ID:MM_ACW:29411
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:EIF2AK4.LSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362118,256,596 - 118,257,096 (+)MPROMDB
RGD ID:6831232
Promoter ID:MM_KWN:31164
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000110869
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362118,263,416 - 118,263,916 (+)MPROMDB
RGD ID:6878288
Promoter ID:EPDNEW_M2595
Type:initiation region
Name:Eif2ak4_1
Description:Mus musculus eukaryotic translation initiation factor 2 alphakinase 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2596  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382118,388,662 - 118,388,722EPDNEW
RGD ID:6878290
Promoter ID:EPDNEW_M2596
Type:multiple initiation site
Name:Eif2ak4_2
Description:Mus musculus eukaryotic translation initiation factor 2 alphakinase 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2595  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382118,423,419 - 118,423,479EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353427 AgrOrtholog
Ensembl Genes ENSMUSG00000005102 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000005233 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000099586 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000106493 UniProtKB/Swiss-Prot
  ENSMUSP00000106494 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000106496 UniProtKB/TrEMBL
  ENSMUSP00000106498 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000106501 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005233 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000102527 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000110869 UniProtKB/Swiss-Prot
  ENSMUST00000110870 UniProtKB/Swiss-Prot
  ENSMUST00000110872 UniProtKB/TrEMBL
  ENSMUST00000110874 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000110877 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Anticodon-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gcn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HisRS-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HisRS-related_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1353427 ENTREZGENE
NCBI Gene 27103 ENTREZGENE
Pfam HGTP_anticodon2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA-synt_His UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak4 PhenoGen
PIRSF Ser/Thr_PK_GCN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AUL9_MOUSE UniProtKB/TrEMBL
  A2AUM0 ENTREZGENE, UniProtKB/TrEMBL
  A2AUM1_MOUSE UniProtKB/TrEMBL
  A2AUM2_MOUSE UniProtKB/TrEMBL
  E2AK4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2AUM3 UniProtKB/Swiss-Prot
  A2AUM4 UniProtKB/Swiss-Prot
  Q6GQT4 UniProtKB/Swiss-Prot
  Q6ZPT5 UniProtKB/Swiss-Prot
  Q8C5S0 UniProtKB/Swiss-Prot
  Q8CIF5 UniProtKB/Swiss-Prot
  Q9CT30 UniProtKB/Swiss-Prot
  Q9CUV9 UniProtKB/Swiss-Prot
  Q9ESB6 UniProtKB/Swiss-Prot
  Q9ESB7 UniProtKB/Swiss-Prot
  Q9ESB8 UniProtKB/Swiss-Prot