Rnase6 (ribonuclease, RNase A family, 6) - Rat Genome Database

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Gene: Rnase6 (ribonuclease, RNase A family, 6) Mus musculus
Analyze
Symbol: Rnase6
Name: ribonuclease, RNase A family, 6
RGD ID: 1331923
MGI Page MGI
Description: Predicted to enable RNA nuclease activity. Involved in defense response to other organism. Located in extracellular space. Orthologous to human RNASE6 (ribonuclease A family member k6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9530043P15Rik; BB119466; expressed sequence BB119466; ribonuclease A family, member 6; ribonuclease K6; RNase K6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,361,365 - 51,369,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,361,365 - 51,369,644 (+)EnsemblGRCm39 Ensembl
GRCm381451,123,908 - 51,132,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,123,908 - 51,132,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,748,743 - 51,750,797 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,051,041 - 50,052,975 (+)NCBIMGSCv36mm8
Celera1447,424,272 - 47,426,326 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Cho S, etal., Genomics. 2005 Feb;85(2):208-20.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15693621   PMID:16141072   PMID:16141073   PMID:21873635   PMID:25075772  


Genomics

Comparative Map Data
Rnase6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,361,365 - 51,369,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,361,365 - 51,369,644 (+)EnsemblGRCm39 Ensembl
GRCm381451,123,908 - 51,132,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,123,908 - 51,132,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,748,743 - 51,750,797 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,051,041 - 50,052,975 (+)NCBIMGSCv36mm8
Celera1447,424,272 - 47,426,326 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.39NCBI
RNASE6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,781,070 - 20,782,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,781,268 - 20,782,467 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,249,427 - 21,250,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,319,050 - 20,320,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,319,049 - 20,320,464NCBI
Celera141,110,074 - 1,111,490 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,370,222 - 1,371,638 (+)NCBIHuRef
CHM1_11421,251,198 - 21,252,614 (+)NCBICHM1_1
T2T-CHM13v2.01414,978,092 - 14,979,588 (+)NCBIT2T-CHM13v2.0
Rnase6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,827,896 - 26,830,807 (+)NCBIGRCr8
mRatBN7.21524,354,305 - 24,357,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,354,303 - 24,357,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,127,289 - 27,127,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,086,431 - 28,086,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,335,850 - 26,336,311 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,080,307 - 28,084,269 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,081,004 - 28,081,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,888,498 - 31,906,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,117,646 - 27,118,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,133,345 - 27,133,807 (+)NCBI
Celera1524,673,730 - 24,674,191 (+)NCBICelera
Cytogenetic Map15p14NCBI
Rnase6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555501,687,068 - 1,688,160 (-)NCBIChiLan1.0ChiLan1.0
RNASE6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,278,035 - 22,279,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,494,353 - 21,496,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,642,819 - 1,644,582 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,699,881 - 19,701,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,700,536 - 19,700,988 (+)Ensemblpanpan1.1panPan2
LOC106559796
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,024,375 - 18,025,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,509,979 - 18,511,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,285,311 - 18,286,754 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11517,966,610 - 17,968,121 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,022,678 - 18,024,183 (+)NCBIUNSW_CanFamBas_1.0
Rnase6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,168,616 - 32,169,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688078,081 - 79,021 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688078,532 - 79,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASE6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,220,131 - 78,221,665 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,220,131 - 78,221,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNASE6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,285,708 - 21,287,452 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,286,685 - 21,287,134 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,143,712 - 25,145,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnase6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,468,213 - 4,469,566 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,468,213 - 4,469,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnase6
262 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:136
Interacting mature miRNAs:143
Transcripts:ENSMUST00000095923
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse

Markers in Region
BB119466  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381451,132,041 - 51,132,143UniSTSGRCm38
MGSCv371451,751,716 - 51,751,818UniSTSGRCm37
Celera1447,427,245 - 47,427,347UniSTS
Cytogenetic Map14C1UniSTS
Whitehead/MRC_RH14575.05UniSTS
Rnase6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C1UniSTS
cM Map14 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095923   ⟹   ENSMUSP00000093613
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,366,525 - 51,368,579 (+)Ensembl
GRCm38.p6 Ensembl1451,129,068 - 51,131,122 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226194   ⟹   ENSMUSP00000154125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,361,365 - 51,369,644 (+)Ensembl
GRCm38.p6 Ensembl1451,123,908 - 51,132,187 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226210   ⟹   ENSMUSP00000154794
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,366,306 - 51,367,710 (+)Ensembl
GRCm38.p6 Ensembl1451,128,849 - 51,130,253 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,366,538 - 51,368,168 (+)Ensembl
GRCm38.p6 Ensembl1451,129,081 - 51,130,711 (+)Ensembl
RefSeq Acc Id: NM_001360117   ⟹   NP_001347046
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,361,365 - 51,369,644 (+)NCBI
GRCm381451,123,908 - 51,132,187 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030098   ⟹   NP_084374
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,366,494 - 51,369,644 (+)NCBI
GRCm381451,129,037 - 51,132,187 (+)NCBI
MGSCv371451,748,743 - 51,750,797 (+)RGD
Celera1447,424,272 - 47,426,326 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153407
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,366,521 - 51,369,644 (+)NCBI
GRCm381451,129,064 - 51,132,187 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_084374   ⟸   NM_030098
- Peptide Label: precursor
- UniProtKB: Q6QDX5 (UniProtKB/Swiss-Prot),   A2RTT6 (UniProtKB/Swiss-Prot),   Q9D244 (UniProtKB/Swiss-Prot),   Q3V3L3 (UniProtKB/TrEMBL),   W0UTF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347046   ⟸   NM_001360117
- Peptide Label: precursor
- UniProtKB: Q9D244 (UniProtKB/Swiss-Prot),   Q6QDX5 (UniProtKB/Swiss-Prot),   A2RTT6 (UniProtKB/Swiss-Prot),   Q3V3L3 (UniProtKB/TrEMBL),   W0UTF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000093613   ⟸   ENSMUST00000095923
RefSeq Acc Id: ENSMUSP00000154794   ⟸   ENSMUST00000226210
RefSeq Acc Id: ENSMUSP00000154125   ⟸   ENSMUST00000226194
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D244-F1-model_v2 AlphaFold Q9D244 1-153 view protein structure

Promoters
RGD ID:8682150
Promoter ID:EPDNEW_M19106
Type:initiation region
Name:Rnase6_1
Description:Mus musculus ribonuclease, RNase A family, 6 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381451,129,062 - 51,129,122EPDNEW
RGD ID:6825344
Promoter ID:MM_KWN:16586
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:UC007TMR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361451,748,579 - 51,749,079 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925666 AgrOrtholog
Ensembl Genes ENSMUSG00000021880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095923 ENTREZGENE
  ENSMUST00000095923.4 UniProtKB/TrEMBL
  ENSMUST00000226194 ENTREZGENE
  ENSMUST00000226194.2 UniProtKB/TrEMBL
  ENSMUST00000226210.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1925666 ENTREZGENE
NCBI Gene 78416 ENTREZGENE
PANTHER PTHR11437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEASE K6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RNASE6 RGD
PhenoGen Rnase6 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BS15_MOUSE UniProtKB/TrEMBL
  A2RTT6 ENTREZGENE
  Q3V3L3 ENTREZGENE, UniProtKB/TrEMBL
  Q6QDX5 ENTREZGENE
  Q9D244 ENTREZGENE, UniProtKB/Swiss-Prot
  W0UTF2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A2RTT6 UniProtKB/Swiss-Prot
  Q6QDX5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Rnase6  ribonuclease, RNase A family, 6  BB119466  expressed sequence BB119466  Data merged from RGD:1611585 737654 PROVISIONAL