Aoc1l3 (amine oxidase copper containing 1-like 3) - Rat Genome Database

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Gene: Aoc1l3 (amine oxidase copper containing 1-like 3) Mus musculus
Analyze
No known orthologs.
Symbol: Aoc1l3
Name: amine oxidase copper containing 1-like 3
RGD ID: 1331910
MGI Page MGI
Description: Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Is expressed in skeleton. Orthologous to human AOC1 (amine oxidase copper containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9530003A11; MGC159338; seminal vesicle secretion 1; seminal vesicle secretory protein 1; seminal vesicle-secreted protein I; Svs1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,963,795 - 48,968,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,963,795 - 48,968,656 (+)EnsemblGRCm39 Ensembl
GRCm38648,986,861 - 48,991,725 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,986,861 - 48,991,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv37648,936,860 - 48,941,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,916,447 - 48,921,308 (+)NCBIMGSCv36mm8
Celera649,497,085 - 49,501,949 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of complementary DNA encoding mouse seminal vesicle-secreted protein SVS I and demonstration of homology with copper amine oxidases. Lundwall A, etal., Biol Reprod 2003 Dec;69(6):1923-30. Epub 2003 Aug 20.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:19452452   PMID:21267068   PMID:21873635  


Genomics

Variants

.
Variants in Aoc1l3
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:115
Interacting mature miRNAs:118
Transcripts:ENSMUST00000037696
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64444280571096451Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4870349075424693Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037696   ⟹   ENSMUSP00000045221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl648,963,795 - 48,968,656 (+)Ensembl
GRCm38.p6 Ensembl648,986,861 - 48,991,722 (+)Ensembl
RefSeq Acc Id: NM_172888   ⟹   NP_766476
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39648,963,795 - 48,968,659 (+)NCBI
GRCm38648,986,861 - 48,991,725 (+)ENTREZGENE
MGSCv37648,936,860 - 48,941,724 (+)RGD
Celera649,497,085 - 49,501,949 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_766476   ⟸   NM_172888
- Peptide Label: precursor
- UniProtKB: Q6WIZ7 (UniProtKB/TrEMBL),   Q8BZI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000045221   ⟸   ENSMUST00000037696
Protein Domains
Copper amine oxidase catalytic   Copper amine oxidase N2-terminal   Copper amine oxidase N3-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6WIZ7-F1-model_v2 AlphaFold Q6WIZ7 1-820 view protein structure

Promoters
RGD ID:6889656
Promoter ID:EPDNEW_M8279
Type:multiple initiation site
Name:Svs1_1
Description:Mus musculus seminal vesicle secretory protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38648,986,904 - 48,986,964EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2682321 AgrOrtholog
Ensembl Genes ENSMUSG00000039215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037696 ENTREZGENE
  ENSMUST00000037696.6 UniProtKB/TrEMBL
Gene3D-CATH 2.70.98.20 UniProtKB/TrEMBL
  3.10.450.40 UniProtKB/TrEMBL
InterPro Cu_amine_oxidase UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/TrEMBL
  Cu_amine_oxidase_N3 UniProtKB/TrEMBL
KEGG Report mmu:243377 UniProtKB/TrEMBL
MGD MGI:2682321 ENTREZGENE
NCBI Gene 243377 ENTREZGENE
PANTHER AMINE OXIDASE UniProtKB/TrEMBL
  CuNH_oxidase UniProtKB/TrEMBL
Pfam Cu_amine_oxid UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/TrEMBL
  Cu_amine_oxidN3 UniProtKB/TrEMBL
PhenoGen Aoc1l3 PhenoGen
PRINTS CUDAOXIDASE UniProtKB/TrEMBL
Superfamily-SCOP Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  CuNH_oxidase UniProtKB/TrEMBL
UniProt Q6WIZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q8BZI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-12 Aoc1l3  amine oxidase copper containing 1-like 3  Svs1  seminal vesicle secretory protein 1  Symbol and/or name updated 27372883 PROVISIONAL