Pld6 (phospholipase D family, member 6)

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Gene: Pld6 (phospholipase D family, member 6) Mus musculus

Analyze

Symbol:

Pld6

Name:

phospholipase D family, member 6

RGD ID:

1323732

MGI Page

MGI

Description:

Orthologous to human PLD6 (phospholipase D family member 6); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; Benzo[ghi]perylene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

4933433K01Rik; choline phosphatase 6; Gm10; mit; mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; mitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D6; PLD 6; RP23-180B18.2; Zuc; zucchini homolog

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLD6 (phospholipase D family member 6)	HGNC	EggNOG, Ensembl, HGNC, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Pld6 (phospholipase D family, member 6)	HGNC	Treefam, EggNOG, NCBI, OMA, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Pld6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLD6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLD6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pld6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLD6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	PLD6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pld6 (phospholipase D family member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Pld6 (phospholipase D family, member 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	PLD6 (phospholipase D family member 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	pld6 (phospholipase D family, member 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	zuc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	59,674,719 - 59,678,483 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	59,674,723 - 59,678,471 (-)	Ensembl
GRCm38	11	59,783,893 - 59,787,657 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	59,783,897 - 59,787,645 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	59,597,395 - 59,601,159 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	59,599,791 - 59,603,846 (-)	NCBI			mm8
MGSCv36	11	60,320,176 - 60,324,231 (-)	NCBI			mm8
Cytogenetic Map	11	B1.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Potocki-Lupski syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-hydroxypropanoic acid (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

carbon nanotube (EXP)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dibenz[a,h]anthracene (EXP)

dibutyl phthalate (EXP)

dichloroacetic acid (EXP)

dicrotophos (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sulforaphane (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

torcetrapib (ISO)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

DNA methylation involved in gamete generation (IMP)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

meiotic cell cycle (IMP)

mitochondrial fusion (ISO)

P granule organization (IMP)

piRNA metabolic process (IBA,IMP)

positive regulation of mitochondrial fusion (ISO)

spermatid development (IMP)

spermatogenesis (IEA)

Cellular Component

endoplasmic reticulum membrane (TAS)

integral component of membrane (IEA)

membrane (IEA)

mitochondrial outer membrane (IBA,IDA,ISO,TAS)

mitochondrion (IEA)

Molecular Function

cardiolipin hydrolase activity (ISO)

catalytic activity (IEA)

endonuclease activity (IEA)

hydrolase activity (IEA)

identical protein binding (IPI)

metal ion binding (IEA)

nuclease activity (IEA)

protein binding (IPI,ISO)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondria fusion pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal DNA methylation during gametogenesis (IAGP)

abnormal male germ cell apoptosis (IAGP)

abnormal male germ cell morphology (IAGP)

abnormal male reproductive system physiology (IAGP)

abnormal mitochondrial morphology (IAGP)

abnormal seminiferous tubule morphology (IAGP)

abnormal spermatid morphology (IAGP)

abnormal spermatocyte morphology (IAGP)

abnormal testis physiology (IAGP)

arrest of male meiosis (IAGP)

azoospermia (IAGP)

male infertility (IAGP)

small testis (IAGP)

References

References - curated


1.	Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
2.	RGD automated import pipeline
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:16141072	PMID:16141073	PMID:21397847	PMID:21397848	PMID:21566194
PMID:21873635	PMID:22281006	PMID:23064227	PMID:23064230	PMID:25762440	PMID:26711011	PMID:27635761	PMID:28115634	PMID:28190767	PMID:28749988	PMID:29113556	PMID:31996847

Genomics

Comparative Map Data

Pld6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	59,674,719 - 59,678,483 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	59,674,723 - 59,678,471 (-)	Ensembl
GRCm38	11	59,783,893 - 59,787,657 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	59,783,897 - 59,787,645 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	59,597,395 - 59,601,159 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	59,599,791 - 59,603,846 (-)	NCBI			mm8
MGSCv36	11	60,320,176 - 60,324,231 (-)	NCBI			mm8
Cytogenetic Map	11	B1.3	NCBI

PLD6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	17,200,995 - 17,206,333 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	17,200,990 - 17,206,905 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	17,104,309 - 17,109,647 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,045,034 - 17,050,357 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	17	18,043,902 - 18,049,239 (-)	NCBI
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	16,857,227 - 16,862,559 (-)	NCBI		HuRef
CHM1_1	17	17,113,918 - 17,119,251 (-)	NCBI		CHM1_1

Pld6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	44,577,740 - 44,581,686 (-)	NCBI
Rnor_6.0 Ensembl	10	46,142,801 - 46,145,548 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	46,142,313 - 46,145,774 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	45,898,760 - 45,902,238 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,100,022 - 46,102,563 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	46,113,644 - 46,116,186 (-)	NCBI
Celera	10	43,839,656 - 43,843,117 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Pld6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955577	698,741 - 702,977 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLD6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	39,016,859 - 39,023,398 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	39,016,859 - 39,023,398 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	34,084,634 - 34,091,470 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

PLD6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	42,208,609 - 42,210,796 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	42,208,594 - 42,212,403 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Pld6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936741	867,501 - 872,899 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLD6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	61,057,944 - 61,060,679 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	61,057,896 - 61,060,681 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PLD6
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	16,237,179 - 16,240,976 (-)	NCBI

Pld6
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624849	4,202,398 - 4,245,217 (+)	NCBI

Position Markers

AW213769

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	59,784,044 - 59,784,136	UniSTS	GRCm38
MGSCv37	11	59,597,546 - 59,597,638	UniSTS	GRCm37
Cytogenetic Map	11	B1.3	UniSTS
Whitehead/MRC_RH	11	791.52	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
27226798	Scvln18_m	sacral vertebrae length 2, 16 week (mouse)					11	3300000	60800000	Mouse
26884446	Sklq10_m	skull length QTL 10, 10 week (mouse)					11	3300000	63000000	Mouse
26884453	Sklq16_m	skull length QTL 16, 16 week (mouse)					11	3300000	72800000	Mouse
13208559	Wght10_m	weight 10 (mouse)					11	4000000	89000000	Mouse
13208558	Lgth12_m	body length 12 (mouse)					11	4000000	95000000	Mouse
1300905	Scc6_m	colon tumor susceptibility 6 (mouse)			Not determined		11	6930277	89128908	Mouse
27226738	Metcl11_m	metatarsal-calcaneal length 11, 10 week (mouse)					11	8900000	61500000	Mouse
26884401	Huml4_m	humerus length 4, 10 week (mouse)					11	11600000	68600000	Mouse
27226762	Feml21_m	femur length 21, 16 week (mouse)					11	11800000	66100000	Mouse
4141966	Tailq1_m	tail length QTL 1 (mouse)			Not determined			12318637	68609504	Mouse
1357851	Scfq3_m	subcutaneous fat pad weight QTL 3 (mouse)			Not determined		11	12318637	68609504	Mouse
1357437	Epfq4_m	epididymal fat pad weight QTL 4 (mouse)			Not determined		11	12318637	68609504	Mouse
4141127	W3q4_m	weight 3 weeks QTL 4 (mouse)			Not determined			12318637	68609504	Mouse
4142216	Lgq1_m	late growth QTL 1 (mouse)			Not determined			12318637	68609504	Mouse
4142308	W6q3_m	weight 6 weeks QTL 3 (mouse)			Not determined		11	12318637	68609504	Mouse
4141582	Lgaq1_m	late growth adjusted QTL 1 (mouse)			Not determined			12318637	68609504	Mouse
4142109	W10q2_m	weight 10 weeks QTL 2 (mouse)			Not determined			12318637	68609504	Mouse
4141470	Egq4_m	early growth QTL 4 (mouse)			Not determined			12318637	68609504	Mouse
1357640	Orq2_m	ovulation rate QTL 2 (mouse)			Not determined		11	12318637	68609504	Mouse
1357720	Kidpq1_m	kidney weight percentage QTL 1 (mouse)			Not determined		11	12318637	68609504	Mouse
1559002	Lmrq4_m	Leishmania major resistance QTL 4 (mouse)			Not determined		11	12318637	69794121	Mouse
1357859	Lvrq7_m	liver weight QTL 7 (mouse)			Not determined		11	12318637	118131898	Mouse
39128214	Lwq20_m	liver weight QTL 20 (mouse)					11	12318637	118131898	Mouse
1558945	Orgwq8_m	organ weight QTL 8 (mouse)			Not determined		11	17106175	67187585	Mouse
10053687	Eae6_m	susceptibility to experimental allergic encephalomyelitis 6 (mouse)			Not determined		11	17831966	68609504	Mouse
4141894	Nidd6k_m	Nidd6 on KK-A (mouse)			Not determined			19174204	97007000	Mouse
10412246	Dfs2_m	dental fluorosis suseptibility 2 (mouse)			Not determined		11	21857364	95990405	Mouse
10044006	Hbnr13_m	Heligmosomoides bakeri nematode resistance 13 (mouse)			Not determined		11	25881799	59881914	Mouse
1357844	Si5lq5_m	serum IGFBP-5 level QTL 5 (mouse)			Not determined		11	28275046	62275149	Mouse
13524848	Ppiq7_m	prepulse inhibition QTL 7 (mouse)					11	28678320	62678320	Mouse
1301426	Desp2_m	despair 2 (mouse)			Not determined		11	28817754	62817873	Mouse
11522752	Cocia18_m	cocaine-induced activity, QTL 18 (mouse)					11	31117382	65117382	Mouse
11059563	Lmr31_m	leishmaniasis resistance 31 (mouse)					11	32209750	66209867	Mouse
1357782	Char8_m	P. chabaudi malaria resistance QTL 8 (mouse)			Not determined		11	35687789	69794161	Mouse
13208569	Bmiq10_m	body mass index QTL 10 (mouse)					11	36000000	85000000	Mouse
1301328	Mol4_m	modifier of LPS-response 4 (mouse)			Not determined		11	36391750	83590530	Mouse
1301788	Lbw8_m	lupus NZB x NZW 8 (mouse)			Not determined		11	36612460	70618665	Mouse
1301896	Tria1_m	T-cell receptor induced activation 1 (mouse)			Not determined		11	36722738	70723028	Mouse
4141853	Skmw17_m	skeletal muscle weight 17 (mouse)			Not determined		11	37190115	71190238	Mouse
4142475	Ity2a_m	immunity to S. typhimurium 2a (mouse)			Not determined		11	37877753	60511890	Mouse
10766457	Nwa3_m	New Zealand White autoimmunity 3 (mouse)					11	38125289	72125383	Mouse
11532698	Sluc36a_m	susceptibility to lung cancer 36a (mouse)					11	42365791	76365904	Mouse
11532699	Sluc36b_m	susceptibility to lung cancer 36b (mouse)					11	42365791	76365904	Mouse
4142300	Ctrq3_m	C. trachomatis resistance QTL 3 (mouse)			Not determined		11	44739211	76963931	Mouse
4141367	Inf1_m	acute ozone induced inflammation (mouse)			Not determined			44739211	113167183	Mouse
4141000	Nidd3_m	non-insulin-dependent diabetes mellitus 3 (mouse)			Not determined			45151201	79151308	Mouse
1302021	Nidd1n_m	non-insulin-dependent diabetes mellitus 1 in NSY (mouse)			Not determined		11	45275046	80087498	Mouse
1357878	Mastr_m	modifier of astrocytoma (mouse)			Not determined		11	45817754	89927907	Mouse
1300765	Bbaa4_m	B.burgdorferi-associated arthritis 4 (mouse)			Not determined		11	46294341	80294436	Mouse
1301988	Bmd11_m	bone mineral density 11 (mouse)			Not determined		11	46428581	80428696	Mouse
1301830	Ssta4_m	susceptibility to Salmonella typhimurium antigens 4 (mouse)			Not determined		11	50187365	84187585	Mouse
13524840	Ppiq9a_m	prepulse inhibition QTL 9a (mouse)					11	52603559	86603559	Mouse
1300774	Pgia7_m	proteoglycan induced arthritis 7 (mouse)			Not determined		11	53499762	87499911	Mouse
4141084	Spqq1_m	sperm quality QTL 1 (mouse)			Not determined			54174844	63428696	Mouse
1302186	Blmpf2_m	bleomycin-induced pulmonary fibrosis 2 (mouse)			Not determined		11	54174844	67187585	Mouse
4142148	Ckdbp2_m	chronic kidney disease blood pressure locus 2 (mouse)			Not determined		11	54190115	65213015	Mouse
4141830	Pregq1_m	pregnancy QTL 1 (mouse)			Not determined		11	54235926	83842826	Mouse
4141875	Etax9_m	ethanol induced ataxia 9 (mouse)			Not determined			55394159	72319101	Mouse
4142121	Tmc1m2_m	Tmc1 modifier 2 (mouse)			Not determined		11	56973201	114267131	Mouse
1300664	Etohcta9_m	ethanol conditioned taste aversion 9 (mouse)			Not determined		11	57863834	91863932	Mouse
10053682	Eae45_m	experimental allergic encephalomyelitis susceptibility 45 (mouse)			Not determined		11	58599729	74863932	Mouse
1300924	Ity2_m	immunity to S. typhimurium 2 (mouse)			Not determined		1	58617204	87804412	Mouse
4141982	Skts-fp2_m	skin tumor susceptibility in FVB and PWK 2 (mouse)			Not determined			58828440	85175703	Mouse
11532697	Sluc36_m	susceptibility to lung cancer 36 (mouse)					11	59365791	69591873	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	307
Count of miRNA genes:	246
Interacting mature miRNAs:	274
Transcripts:	ENSMUST00000051493, ENSMUST00000125307
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001290283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_183139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_110894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK077214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK139586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL596204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW554531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC119245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC145052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG074852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ313398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK137362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000051493

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	59,783,897 - 59,787,645 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000125307 ⟹ ENSMUSP00000115503

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	11	59,784,703 - 59,787,642 (-)	Ensembl

RefSeq Acc Id:

NM_001290283 ⟹ NP_001277212

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	59,674,719 - 59,678,483 (-)	NCBI
GRCm38	11	59,783,893 - 59,787,657 (-)	NCBI

Sequence:

show sequence

GCTGACCTTAGAGGTGGCGGCCATGGGGCGCTCGAGTTGGCGGTTGGTGTTCGCGGCTGGTGCG
GGTCTCGCGCTGGCCCTAGAGGCACTGCCGTGGCTGATGCGTTGGCTGCTGGCTGGGCGGCGGC
CAAGGCGCGAGGTGCTCTTCTTCCCCTCACAGGTGACCTGCACCGAGGCTTTACTGCAGGCCCC
AGGGTTGCCTCCCGGGCCCTCGGGCTGCCCGTGTAGCCTCCCCCACAGCGAGAGTTCACTGAGC
CGCCTGCTGCGCGCGCTGTTGGCCGCCCGCTCCAGCTTGGAGCTCTGCCTCTTCGCCTTCTCCA
GCCCGCAGCTGGGGCGTGCAGTGCAGCTGCTGCATCAGCGTGGGGTGCGCGTGCGGGTCATCAC
TGACTGCGACTACATGGCCCTCAACGGCTCTCAGATCGGCCTGCTGCGCAAGGCAGGGATACAG
GTACGGCACGACCAGGACCTAGGCTACATGCACCACAAGTTTGCCATCGTTGACAAGAAGGTGC
TCATCACCGGCTCCCTCAACTGGACCACACAGGCCATCCAGAACAACCGGGAGAACGTCCTGAT
TATGGAGGACACCGAGTATGTGCGGCTGTTCCTGGAGGAGTTTGAGCGCATCTGGGAAGAATTT
GACCCCACCAAGTACAGCTTTTTCCCCCAAAAGCATCGAGGGCACTGACCCTGCTTTGTTTGCT
CCTCTTCCAGCTTGTGCTTGTGATGTCCCCTCCTGCTTTGCATGAGCCTTTCCTGGCTGGCTGG
GGAGCAGCTGCCAGTCTTCCTGTGCATGCAGCCCCAGCAGAAGTTAGGAAGGTGACAGTGTTGG
ACAGTACTGTAGGCTCCCTAGTACTTGCCTAGATAGGCAGCATCCTCTCCTGGGCATCACTAGA
CAGGCCTCAGAGTGCATTGGCCCTTGTCTCCAAGGCAGTGTTTAGTCGCTGGTGGGCACTACCC
ATTGGCCACGCCTGCAGCTTGCCCAGGCTTTGCTTTGCTTGTCCGTGCCCCTCACACGTAGAGC
CAGACTGTGGACTTGGGAGGGGCCTCGCCTCTAGCCCTGTGGTGGACTCTGCGTTTACTCAGTA
GTGGATCAGAAGCTGACGACAAAGGGAACCCTGGAGGTAAGCAGGCTGCCCAGGCTGTTACCTC
AGCTCTGCTGGGCACTGACAGGAGTCGGAGGAACAGCTTCTCGCGCACATCTGTGACATGAGTT
GCATTTTGTCATTGTTCATGCTTGTGTGCACGACAAACTCCATGCGGCTCCTGACGTGTCTGTC
CTTTAACTTAACAGCAGACACTGTGCAATGCATGTTTTCTCACTTAAAAACATTTTTTTGGGGG
GTGGGGGTGGAAGGAGGTGGGGAGGGTCTCACTCTGTAGCCCTGGCTAACCTGGAACTCACTAT
GTAGTCTAGGCTAGTCTTCAGTTCAGAGATCTGCCGGGTTTGCTTCAAGCACTGGGATTAAAGG
CGTGCACCACCAGACCCTGCTGTTTTCGCACTTTTTTTTTCTTTTTTTTTTTTTTTAAGGAAAG
GAAAGAGGAAGGGAGAGTGGGGGGAGCATGTTGGAGTAACAAGTCCTGATATCCCCTTCTTGGG
CCACCCTTAGCCTCTCTTCCTCAGGTCCTCAATCCCATGTTTTCACACTTTTTAACGTTCCTTT
TACTTAGTGTTAGACAAGTAAACTTGATGTTGATTTTCCAAAAGATTGAACAGAAACGGAGACC
CTTAACTTGTGGCATATTTCAATAAATATTTTCAAGTATGAGCTG

hide sequence

RefSeq Acc Id:

NM_183139 ⟹ NP_898962

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	59,674,719 - 59,678,483 (-)	NCBI
GRCm38	11	59,783,893 - 59,787,657 (-)	NCBI
MGSCv37	11	59,597,395 - 59,601,159 (-)	RGD
cM Map	11		ENTREZGENE

Sequence:

show sequence

GCTGACCTTAGAGGTGGCGGCCATGGGGCGCTCGAGTTGGCGGTTGGTGTTCGCGGCTGGTGCG
GGTCTCGCGCTGGCCCTAGAGGCACTGCCGTGGCTGATGCGTTGGCTGCTGGCTGGGCGGCGGC
CAAGGCGCGAGGTGCTCTTCTTCCCCTCACAGGTGACCTGCACCGAGGCTTTACTGCAGGCCCC
AGGGTTGCCTCCCGGGCCCTCGGGCTGCCCGTGTAGCCTCCCCCACAGCGAGAGTTCACTGAGC
CGCCTGCTGCGCGCGCTGTTGGCCGCCCGCTCCAGCTTGGAGCTCTGCCTCTTCGCCTTCTCCA
GCCCGCAGCTGGGGCGTGCAGTGCAGCTGCTGCATCAGCGTGGGGTGCGCGTGCGGGTCATCAC
TGACTGCGACTACATGGCCCTCAACGGCTCTCAGATCGGCCTGCTGCGCAAGGGATACAGGTAC
GGCACGACCAGGACCTAGGCTACATGCACCACAAGTTTGCCATCGTTGACAAGAAGGTGCTCAT
CACCGGCTCCCTCAACTGGACCACACAGGCCATCCAGAACAACCGGGAGAACGTCCTGATTATG
GAGGACACCGAGTATGTGCGGCTGTTCCTGGAGGAGTTTGAGCGCATCTGGGAAGAATTTGACC
CCACCAAGTACAGCTTTTTCCCCCAAAAGCATCGAGGGCACTGACCCTGCTTTGTTTGCTCCTC
TTCCAGCTTGTGCTTGTGATGTCCCCTCCTGCTTTGCATGAGCCTTTCCTGGCTGGCTGGGGAG
CAGCTGCCAGTCTTCCTGTGCATGCAGCCCCAGCAGAAGTTAGGAAGGTGACAGTGTTGGACAG
TACTGTAGGCTCCCTAGTACTTGCCTAGATAGGCAGCATCCTCTCCTGGGCATCACTAGACAGG
CCTCAGAGTGCATTGGCCCTTGTCTCCAAGGCAGTGTTTAGTCGCTGGTGGGCACTACCCATTG
GCCACGCCTGCAGCTTGCCCAGGCTTTGCTTTGCTTGTCCGTGCCCCTCACACGTAGAGCCAGA
CTGTGGACTTGGGAGGGGCCTCGCCTCTAGCCCTGTGGTGGACTCTGCGTTTACTCAGTAGTGG
ATCAGAAGCTGACGACAAAGGGAACCCTGGAGGTAAGCAGGCTGCCCAGGCTGTTACCTCAGCT
CTGCTGGGCACTGACAGGAGTCGGAGGAACAGCTTCTCGCGCACATCTGTGACATGAGTTGCAT
TTTGTCATTGTTCATGCTTGTGTGCACGACAAACTCCATGCGGCTCCTGACGTGTCTGTCCTTT
AACTTAACAGCAGACACTGTGCAATGCATGTTTTCTCACTTAAAAACATTTTTTTGGGGGGTGG
GGGTGGAAGGAGGTGGGGAGGGTCTCACTCTGTAGCCCTGGCTAACCTGGAACTCACTATGTAG
TCTAGGCTAGTCTTCAGTTCAGAGATCTGCCGGGTTTGCTTCAAGCACTGGGATTAAAGGCGTG
CACCACCAGACCCTGCTGTTTTCGCACTTTTTTTTTCTTTTTTTTTTTTTTTAAGGAAAGGAAA
GAGGAAGGGAGAGTGGGGGGAGCATGTTGGAGTAACAAGTCCTGATATCCCCTTCTTGGGCCAC
CCTTAGCCTCTCTTCCTCAGGTCCTCAATCCCATGTTTTCACACTTTTTAACGTTCCTTTTACT
TAGTGTTAGACAAGTAAACTTGATGTTGATTTTCCAAAAGATTGAACAGAAACGGAGACCCTTA
ACTTGTGGCATATTTCAATAAATATTTTCAAGTATGAGCTG

hide sequence

RefSeq Acc Id:

NR_110894

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	59,674,719 - 59,678,048 (-)	NCBI
GRCm38	11	59,783,893 - 59,787,222 (-)	NCBI

Sequence:

show sequence

GGCAGGTAAACCGCCGCCGAGGGTGCACACCGGCAGAGGGGTAGAGGACTTACTTGATGCCCCT
ACCGACTTTGTCCAGAGCAGGTAGCATTTCAGGGAGAAAGGTGGAGGCAGGCAGGCAGAGATGA
GCGGGCCAAGGAGCCAAGGTTCATAGTCTGTTATATTCCGTGTCTGGGCTCCCCATGAGTAAGG
GATACAGGTACGGCACGACCAGGACCTAGGCTACATGCACCACAAGTTTGCCATCGTTGACAAG
AAGGTGCTCATCACCGGCTCCCTCAACTGGACCACACAGGCCATCCAGAACAACCGGGAGAACG
TCCTGATTATGGAGGACACCGAGTATGTGCGGCTGTTCCTGGAGGAGTTTGAGCGCATCTGGGA
AGAATTTGACCCCACCAAGTACAGCTTTTTCCCCCAAAAGCATCGAGGGCACTGACCCTGCTTT
GTTTGCTCCTCTTCCAGCTTGTGCTTGTGATGTCCCCTCCTGCTTTGCATGAGCCTTTCCTGGC
TGGCTGGGGAGCAGCTGCCAGTCTTCCTGTGCATGCAGCCCCAGCAGAAGTTAGGAAGGTGACA
GTGTTGGACAGTACTGTAGGCTCCCTAGTACTTGCCTAGATAGGCAGCATCCTCTCCTGGGCAT
CACTAGACAGGCCTCAGAGTGCATTGGCCCTTGTCTCCAAGGCAGTGTTTAGTCGCTGGTGGGC
ACTACCCATTGGCCACGCCTGCAGCTTGCCCAGGCTTTGCTTTGCTTGTCCGTGCCCCTCACAC
GTAGAGCCAGACTGTGGACTTGGGAGGGGCCTCGCCTCTAGCCCTGTGGTGGACTCTGCGTTTA
CTCAGTAGTGGATCAGAAGCTGACGACAAAGGGAACCCTGGAGGTAAGCAGGCTGCCCAGGCTG
TTACCTCAGCTCTGCTGGGCACTGACAGGAGTCGGAGGAACAGCTTCTCGCGCACATCTGTGAC
ATGAGTTGCATTTTGTCATTGTTCATGCTTGTGTGCACGACAAACTCCATGCGGCTCCTGACGT
GTCTGTCCTTTAACTTAACAGCAGACACTGTGCAATGCATGTTTTCTCACTTAAAAACATTTTT
TTGGGGGGTGGGGGTGGAAGGAGGTGGGGAGGGTCTCACTCTGTAGCCCTGGCTAACCTGGAAC
TCACTATGTAGTCTAGGCTAGTCTTCAGTTCAGAGATCTGCCGGGTTTGCTTCAAGCACTGGGA
TTAAAGGCGTGCACCACCAGACCCTGCTGTTTTCGCACTTTTTTTTTCTTTTTTTTTTTTTTTA
AGGAAAGGAAAGAGGAAGGGAGAGTGGGGGGAGCATGTTGGAGTAACAAGTCCTGATATCCCCT
TCTTGGGCCACCCTTAGCCTCTCTTCCTCAGGTCCTCAATCCCATGTTTTCACACTTTTTAACG
TTCCTTTTACTTAGTGTTAGACAAGTAAACTTGATGTTGATTTTCCAAAAGATTGAACAGAAAC
GGAGACCCTTAACTTGTGGCATATTTCAATAAATATTTTCAAGTATGAGCTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001277212	(Get FASTA)	NCBI Sequence Viewer
	NP_898962	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI19246	(Get FASTA)	NCBI Sequence Viewer
	AAI45053	(Get FASTA)	NCBI Sequence Viewer
	BAC36687	(Get FASTA)	NCBI Sequence Viewer
	BAE24077	(Get FASTA)	NCBI Sequence Viewer
	Q5SWZ9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_898962 ⟸ NM_183139
- Peptide Label:	isoform b
- UniProtKB:	Q5SWZ9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGRSSWRLVFAAGAGLALALEALPWLMRWLLAGRRPRREVLFFPSQVTCTEALLQAPGLPPGPS GCPCSLPHSESSLSRLLRALLAARSSLELCLFAFSSPQLGRAVQLLHQRGVRVRVITDCDYMAL NGSQIGLLRKGYRYGTTRT hide sequence

RefSeq Acc Id:	NP_001277212 ⟸ NM_001290283
- Peptide Label:	isoform a
- UniProtKB:	Q5SWZ9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGRSSWRLVFAAGAGLALALEALPWLMRWLLAGRRPRREVLFFPSQVTCTEALLQAPGLPPGPS GCPCSLPHSESSLSRLLRALLAARSSLELCLFAFSSPQLGRAVQLLHQRGVRVRVITDCDYMAL NGSQIGLLRKAGIQVRHDQDLGYMHHKFAIVDKKVLITGSLNWTTQAIQNNRENVLIMEDTEYV RLFLEEFERIWEEFDPTKYSFFPQKHRGH hide sequence

RefSeq Acc Id:

ENSMUSP00000115503 ⟸ ENSMUST00000125307

Protein Domains

PLD phosphodiesterase

Promoters

RGD ID:

6821567

Promoter ID:

MM_KWN:7665

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain, ES_Cell, Lung, MEF_B6

Transcripts:

NM_183139, OTTMUST00000018402

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	11	59,600,736 - 59,602,027 (-)	MPROMDB

RGD ID:

8674834

Promoter ID:

EPDNEW_M15448

Type:

multiple initiation site

Name:

Pld6_1

Description:

Mus musculus phospholipase D family, member 6 , transcript variant2, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	11	59,787,666 - 59,787,726	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2687283	AgrOrtholog
Ensembl Genes	ENSMUSG00000043648	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000115503	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000051493	ENTREZGENE
	ENSMUST00000125307	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	PLD-like_dom	UniProtKB/Swiss-Prot
	PLipase_D/transphosphatidylase	UniProtKB/Swiss-Prot
KEGG Report	mmu:194908	UniProtKB/Swiss-Prot
MGD	MGI:2687283	ENTREZGENE
NCBI Gene	194908	ENTREZGENE
Pfam	PLDc_2	UniProtKB/Swiss-Prot
PhenoGen	Pld6	PhenoGen
PROSITE	PLD	UniProtKB/Swiss-Prot
SMART	PLDc	UniProtKB/Swiss-Prot
UniProt	PLD6_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	B7ZN71	UniProtKB/Swiss-Prot
	Q3UTA3	UniProtKB/Swiss-Prot
	Q8BVM0	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations