Usp38 (ubiquitin specific peptidase 38) - Rat Genome Database
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Gene: Usp38 (ubiquitin specific peptidase 38) Mus musculus
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Symbol: Usp38
Name: ubiquitin specific peptidase 38
RGD ID: 1323710
MGI Page MGI
Description: Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein deubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including brain; genitourinary system; gut gland; integumental system; and liver and biliary system. Orthologous to human USP38 (ubiquitin specific peptidase 38); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4631402N15Rik; 4833420O05Rik; AA536967; AU044701; AW544820; deubiquitinating enzyme 38; mKIAA1891; ubiquitin carboxyl-terminal hydrolase 38; ubiquitin specific protease 38; ubiquitin thioesterase 38; ubiquitin thiolesterase 38; ubiquitin-specific-processing protease 38
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18601  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39881,707,353 - 81,741,631 (-)NCBIGRCm39mm39
GRCm38880,980,724 - 81,015,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37883,504,632 - 83,538,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36883,876,479 - 83,910,652 (-)NCBImm8
Celera885,259,181 - 85,286,557 (-)NCBICelera
Celera875,127,726 - 75,134,583 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map838.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
nucleus  (IBA)

References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16631325   PMID:17967808   PMID:21267068  
PMID:21873635   PMID:24194600   PMID:25849460   PMID:27626380   PMID:27692986   PMID:28190767   PMID:30224386   PMID:31874856   PMID:32325033  


Genomics

Comparative Map Data
Usp38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39881,707,353 - 81,741,631 (-)NCBIGRCm39mm39
GRCm38880,980,724 - 81,015,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37883,504,632 - 83,538,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36883,876,479 - 83,910,652 (-)NCBImm8
Celera885,259,181 - 85,286,557 (-)NCBICelera
Celera875,127,726 - 75,134,583 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map838.68NCBI
USP38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4143,184,917 - 143,223,874 (+)EnsemblGRCh38hg38GRCh38
GRCh384143,184,917 - 143,224,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374144,106,070 - 144,143,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364144,325,548 - 144,362,090 (+)NCBINCBI36hg18NCBI36
Build 344144,463,702 - 144,500,244NCBI
Celera4141,435,984 - 141,473,049 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4139,835,778 - 139,872,846 (+)NCBIHuRef
CHM1_14144,083,284 - 144,122,234 (+)NCBICHM1_1
Usp38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01930,668,258 - 30,699,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1930,668,602 - 30,699,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01941,576,070 - 41,607,659 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41928,847,283 - 28,879,605 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11928,852,729 - 28,883,368 (+)NCBI
Celera1926,525,530 - 26,557,224 (+)NCBICelera
Cytogenetic Map19q11NCBI
Usp38
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955471315,779 - 350,982 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955471316,319 - 350,982 (-)NCBIChiLan1.0ChiLan1.0
USP38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14146,844,850 - 146,881,486 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4146,844,850 - 146,881,486 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04135,545,818 - 135,582,520 (+)NCBIMhudiblu_PPA_v0panPan3
USP38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl19210,388 - 238,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.119201,810 - 238,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Usp38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365355,146,327 - 5,178,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP38
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl884,567,618 - 84,601,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1884,567,476 - 84,601,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2889,716,675 - 89,724,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP38
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1790,049,643 - 90,087,152 (+)NCBI
ChlSab1.1 Ensembl790,049,638 - 90,089,110 (+)Ensembl
Usp38
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248532,485,347 - 2,519,165 (+)NCBI

Position Markers
AW544820  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,981,092 - 80,981,217UniSTSGRCm38
MGSCv37883,504,991 - 83,505,116UniSTSGRCm37
Celera875,134,099 - 75,134,224UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8865.34UniSTS
AU044701  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,981,040 - 80,981,188UniSTSGRCm38
MGSCv37883,504,939 - 83,505,087UniSTSGRCm37
Celera1945,484,251 - 45,484,399UniSTS
Celera875,134,128 - 75,134,276UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8865.55UniSTS
RH124306  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,985,076 - 80,985,332UniSTSGRCm38
MGSCv37883,508,975 - 83,509,231UniSTSGRCm37
Celera875,129,983 - 75,130,239UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:242
Interacting mature miRNAs:288
Transcripts:ENSMUST00000042724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042724   ⟹   ENSMUSP00000039943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl880,998,213 - 81,014,913 (-)Ensembl
RefSeq Acc Id: NM_027554   ⟹   NP_081830
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,707,362 - 81,741,535 (-)NCBI
GRCm38880,980,733 - 81,014,906 (-)NCBI
MGSCv37883,504,632 - 83,538,805 (-)RGD
Celera885,259,181 - 85,286,557 (-)RGD
Celera875,127,726 - 75,134,583 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531450   ⟹   XP_006531513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,707,353 - 81,727,613 (-)NCBI
GRCm38880,980,724 - 81,000,988 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934893
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,714,162 - 81,741,631 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_081830   ⟸   NM_027554
- UniProtKB: Q8BW70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531513   ⟸   XM_006531450
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000039943   ⟸   ENSMUST00000042724
Protein Domains
USP

Promoters
RGD ID:8667571
Promoter ID:EPDNEW_M11817
Type:initiation region
Name:Usp38_1
Description:Mus musculus ubiquitin specific peptidase 38 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38881,014,907 - 81,014,967EPDNEW
RGD ID:6843869
Promoter ID:MM_KWN:54972
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B6
Transcripts:NM_027554
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36883,538,711 - 83,539,627 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922091 AgrOrtholog
Ensembl Genes ENSMUSG00000038250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039943 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042724 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74841 UniProtKB/Swiss-Prot
MGD MGI:1922091 ENTREZGENE
NCBI Gene 74841 ENTREZGENE
Pfam UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp38 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.246018 ENTREZGENE
UniProt Q6ZPG3_MOUSE UniProtKB/TrEMBL
  Q8BW70 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BWL1 UniProtKB/Swiss-Prot
  Q8BX03 UniProtKB/Swiss-Prot