Usp38 (ubiquitin specific peptidase 38) - Rat Genome Database
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Gene: Usp38 (ubiquitin specific peptidase 38) Mus musculus
Analyze
Symbol: Usp38
Name: ubiquitin specific peptidase 38
RGD ID: 1323710
MGI Page MGI
Description: Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in protein deubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including brain; genitourinary system; gut gland; integumental system; and liver and biliary system. Orthologous to human USP38 (ubiquitin specific peptidase 38); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4631402N15Rik; 4833420O05Rik; AA536967; AU044701; AW544820; deubiquitinating enzyme 38; mKIAA1891; ubiquitin carboxyl-terminal hydrolase 38; ubiquitin specific protease 38; ubiquitin thioesterase 38; ubiquitin thiolesterase 38; ubiquitin-specific-processing protease 38
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18601  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39881,707,353 - 81,741,631 (-)NCBIGRCm39mm39
GRCm38880,980,724 - 81,015,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37883,504,632 - 83,538,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36883,876,479 - 83,910,652 (-)NCBImm8
Celera885,259,181 - 85,286,557 (-)NCBICelera
Celera875,127,726 - 75,134,583 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map838.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
nucleus  (IBA)

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16631325   PMID:17967808   PMID:21267068  
PMID:21873635   PMID:24194600   PMID:25849460   PMID:27626380   PMID:27692986   PMID:28190767   PMID:30224386   PMID:31874856   PMID:32325033  


Genomics

Comparative Map Data
Usp38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39881,707,353 - 81,741,631 (-)NCBIGRCm39mm39
GRCm38880,980,724 - 81,015,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv37883,504,632 - 83,538,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv36883,876,479 - 83,910,652 (-)NCBImm8
Celera885,259,181 - 85,286,557 (-)NCBICelera
Celera875,127,726 - 75,134,583 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map838.68NCBI
USP38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4143,184,917 - 143,223,874 (+)EnsemblGRCh38hg38GRCh38
GRCh384143,184,917 - 143,224,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374144,106,070 - 144,143,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364144,325,548 - 144,362,090 (+)NCBINCBI36hg18NCBI36
Build 344144,463,702 - 144,500,244NCBI
Celera4141,435,984 - 141,473,049 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4139,835,778 - 139,872,846 (+)NCBIHuRef
CHM1_14144,083,284 - 144,122,234 (+)NCBICHM1_1
Usp38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01930,668,258 - 30,699,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1930,668,602 - 30,699,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01941,576,070 - 41,607,659 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41928,847,283 - 28,879,605 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11928,852,729 - 28,883,368 (+)NCBI
Celera1926,525,530 - 26,557,224 (+)NCBICelera
Cytogenetic Map19q11NCBI
Usp38
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955471315,779 - 350,982 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955471316,319 - 350,982 (-)NCBIChiLan1.0ChiLan1.0
USP38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14146,844,850 - 146,881,486 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4146,844,850 - 146,881,486 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04135,545,818 - 135,582,520 (+)NCBIMhudiblu_PPA_v0panPan3
USP38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl19210,388 - 238,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.119201,810 - 238,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Usp38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365355,146,327 - 5,178,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP38
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl884,567,618 - 84,601,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1884,567,476 - 84,601,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2889,716,675 - 89,724,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP38
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1790,049,643 - 90,087,152 (+)NCBI
ChlSab1.1 Ensembl790,049,638 - 90,089,110 (+)Ensembl
Usp38
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248532,485,347 - 2,519,165 (+)NCBI

Position Markers
AW544820  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,981,092 - 80,981,217UniSTSGRCm38
MGSCv37883,504,991 - 83,505,116UniSTSGRCm37
Celera875,134,099 - 75,134,224UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8865.34UniSTS
AU044701  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,981,040 - 80,981,188UniSTSGRCm38
MGSCv37883,504,939 - 83,505,087UniSTSGRCm37
Celera1945,484,251 - 45,484,399UniSTS
Celera875,134,128 - 75,134,276UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS
Whitehead/MRC_RH8865.55UniSTS
RH124306  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38880,985,076 - 80,985,332UniSTSGRCm38
MGSCv37883,508,975 - 83,509,231UniSTSGRCm37
Celera875,129,983 - 75,130,239UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:242
Interacting mature miRNAs:288
Transcripts:ENSMUST00000042724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042724   ⟹   ENSMUSP00000039943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl880,980,733 - 81,014,928 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl880,998,213 - 81,014,913 (-)Ensembl
RefSeq Acc Id: NM_027554   ⟹   NP_081830
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,707,362 - 81,741,535 (-)NCBI
GRCm38880,980,733 - 81,014,906 (-)NCBI
MGSCv37883,504,632 - 83,538,805 (-)RGD
Celera885,259,181 - 85,286,557 (-)RGD
Celera875,127,726 - 75,134,583 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531450   ⟹   XP_006531513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,707,353 - 81,727,613 (-)NCBI
GRCm38880,980,724 - 81,000,988 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934893
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39881,714,162 - 81,741,631 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_081830   ⟸   NM_027554
- UniProtKB: Q8BW70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531513   ⟸   XM_006531450
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000039943   ⟸   ENSMUST00000042724
Protein Domains
USP

Promoters
RGD ID:8667571
Promoter ID:EPDNEW_M11817
Type:initiation region
Name:Usp38_1
Description:Mus musculus ubiquitin specific peptidase 38 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38881,014,907 - 81,014,967EPDNEW
RGD ID:6843869
Promoter ID:MM_KWN:54972
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B6
Transcripts:NM_027554
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36883,538,711 - 83,539,627 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922091 AgrOrtholog
Ensembl Genes ENSMUSG00000038250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039943 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042724 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74841 UniProtKB/Swiss-Prot
MGD MGI:1922091 ENTREZGENE
NCBI Gene 74841 ENTREZGENE
Pfam UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp38 PhenoGen
PROSITE USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.246018 ENTREZGENE
UniProt Q6ZPG3_MOUSE UniProtKB/TrEMBL
  Q8BW70 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BWL1 UniProtKB/Swiss-Prot
  Q8BX03 UniProtKB/Swiss-Prot