Car6 (carbonic anhydrase 6) - Rat Genome Database

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Gene: Car6 (carbonic anhydrase 6) Mus musculus
Analyze
Symbol: Car6
Name: carbonic anhydrase 6
RGD ID: 1323701
MGI Page MGI
Description: Predicted to have carbonate dehydratase activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste and one-carbon metabolic process. Localizes to cytosol and extracellular space. Is expressed in brain. Orthologous to human CA6 (carbonic anhydrase 6); INTERACTS WITH 1,2-dimethylhydrazine; 3,3',5,5'-tetrabromobisphenol A; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CA-VI; Ca6; carbonate dehydratase VI; carbonic anhydrase VI; DOC; DOC1; salivary carbonic anhydrase; secreted carbonic anhydrase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,271,472 - 150,285,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,271,472 - 150,285,789 (-)Ensembl
GRCm384150,187,015 - 150,201,135 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,187,015 - 150,201,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,561,124 - 149,575,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,030,815 - 149,042,270 (-)NCBImm8
Celera4152,461,682 - 152,476,184 (-)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:2497732   PMID:9649432   PMID:9858573   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:17362527   PMID:17626619   PMID:19188447   PMID:19521566   PMID:20820888   PMID:20835760   PMID:20929715   PMID:21873635   PMID:23233153   PMID:24789143   PMID:25134447  
PMID:27209317   PMID:28739930  


Genomics

Comparative Map Data
Car6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,271,472 - 150,285,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,271,472 - 150,285,789 (-)Ensembl
GRCm384150,187,015 - 150,201,135 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,187,015 - 150,201,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,561,124 - 149,575,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,030,815 - 149,042,270 (-)NCBImm8
Celera4152,461,682 - 152,476,184 (-)NCBICelera
Cytogenetic Map4E2NCBI
CA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl18,945,867 - 8,975,092 (+)EnsemblGRCh38hg38GRCh38
GRCh3818,945,868 - 8,975,092 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,005,927 - 9,035,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,928,509 - 8,957,738 (+)NCBINCBI36hg18NCBI36
Build 3418,940,207 - 8,969,412NCBI
Celera18,114,641 - 8,143,865 (+)NCBI
Cytogenetic Map1p36.23NCBI
HuRef18,155,174 - 8,184,890 (+)NCBIHuRef
CHM1_118,995,837 - 9,025,073 (+)NCBICHM1_1
Ca6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,658,104 - 160,676,644 (-)NCBI
Rnor_6.0 Ensembl5167,226,246 - 167,244,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05167,226,246 - 167,244,786 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05170,854,181 - 170,872,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,332,219 - 167,350,880 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15167,342,413 - 167,361,042 (-)NCBI
Celera5158,915,352 - 158,933,838 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ca6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,234,235 - 4,247,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,234,293 - 4,249,026 (-)NCBIChiLan1.0ChiLan1.0
CA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.118,938,158 - 8,966,305 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,938,164 - 8,966,300 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v017,703,187 - 7,732,409 (+)NCBIMhudiblu_PPA_v0panPan3
CA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,358,521 - 62,379,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,358,403 - 62,379,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,375,992 - 62,397,372 (+)NCBI
ROS_Cfam_1.0562,580,266 - 62,606,464 (+)NCBI
UMICH_Zoey_3.1562,583,427 - 62,604,811 (+)NCBI
UNSW_CanFamBas_1.0562,447,719 - 62,469,108 (+)NCBI
UU_Cfam_GSD_1.0562,851,948 - 62,873,335 (+)NCBI
Ca6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,675,341 - 32,703,732 (+)NCBI
SpeTri2.0NW_0049366233,169,095 - 3,188,947 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,447,439 - 69,468,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,447,662 - 69,468,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,673,124 - 63,695,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,777,961 - 122,817,689 (-)NCBI
ChlSab1.1 Ensembl20122,777,895 - 122,810,359 (-)Ensembl
Vero_WHO_p1.0NW_02366605426,799,675 - 26,832,454 (-)NCBI
Ca6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248183,179,847 - 3,193,699 (-)NCBI

Position Markers
Car6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
cM Map4 UniSTS
AF079834  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384150,187,165 - 150,187,256UniSTSGRCm38
MGSCv374149,561,274 - 149,561,365UniSTSGRCm37
Celera4152,461,832 - 152,461,923UniSTS
Cytogenetic Map4E2UniSTS
Whitehead/MRC_RH41935.55UniSTS
RH137414  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384150,187,175 - 150,187,370UniSTSGRCm38
MGSCv374149,561,284 - 149,561,479UniSTSGRCm37
Celera4152,461,842 - 152,462,037UniSTS
Cytogenetic Map4E2UniSTS
Car6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
Car6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:636
Count of miRNA genes:300
Interacting mature miRNAs:353
Transcripts:ENSMUST00000030817, ENSMUST00000105683, ENSMUST00000126449, ENSMUST00000134648
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030817   ⟹   ENSMUSP00000030817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4150,187,015 - 150,201,332 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105683   ⟹   ENSMUSP00000101308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4150,187,015 - 150,198,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4150,188,239 - 150,198,203 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134648
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4150,187,212 - 150,196,123 (-)Ensembl
RefSeq Acc Id: NM_009802   ⟹   NP_033932
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,271,472 - 150,285,592 (-)NCBI
GRCm384150,187,015 - 150,201,135 (-)ENTREZGENE
MGSCv374149,561,124 - 149,575,244 (-)RGD
Celera4152,461,682 - 152,476,184 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033932   ⟸   NM_009802
- Peptide Label: precursor
- UniProtKB: P18761 (UniProtKB/Swiss-Prot),   Q3TTT1 (UniProtKB/TrEMBL),   Q3V197 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000101308   ⟸   ENSMUST00000105683
RefSeq Acc Id: ENSMUSP00000030817   ⟸   ENSMUST00000030817
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:6885604
Promoter ID:EPDNEW_M6253
Type:multiple initiation site
Name:Car6_1
Description:Mus musculus carbonic anhydrase 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384150,201,135 - 150,201,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333786 AgrOrtholog
Ensembl Genes ENSMUSG00000028972 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000030817 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101308 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030817 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105683 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_CA6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333786 ENTREZGENE
NCBI Gene 12353 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Car6 PhenoGen
PROSITE ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1ARR4_MOUSE UniProtKB/TrEMBL
  CAH6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q05DM4_MOUSE UniProtKB/TrEMBL
  Q3TTT1 ENTREZGENE, UniProtKB/TrEMBL
  Q3V197 ENTREZGENE, UniProtKB/TrEMBL
  Q71UK2_MOUSE UniProtKB/TrEMBL
  Q7TNG9_MOUSE UniProtKB/TrEMBL
  Q80YB7_MOUSE UniProtKB/TrEMBL
  Q811E8_MOUSE UniProtKB/TrEMBL
UniProt Secondary B1ARR5 UniProtKB/Swiss-Prot
  O88625 UniProtKB/Swiss-Prot