Umps (uridine monophosphate synthetase) - Rat Genome Database
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Gene: Umps (uridine monophosphate synthetase) Mus musculus
Analyze
Symbol: Umps
Name: uridine monophosphate synthetase
RGD ID: 1323613
MGI Page MGI
Description: Predicted to have identical protein binding activity; orotate phosphoribosyltransferase activity; and orotidine-5'-phosphate decarboxylase activity. Predicted to be involved in UMP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700095D23Rik; AA408257; AL033308; BB164745; UMP synthase; uridine 5'-monophosphate synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,775,152 - 33,787,408 (-)NCBIGRCm39mm39
GRCm381633,954,782 - 33,967,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,954,782 - 33,967,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371633,955,098 - 33,967,089 (-)NCBIGRCm37mm9NCBIm37
MGSCv361633,874,759 - 33,886,750 (-)NCBImm8
Celera1634,439,142 - 34,451,132 (-)NCBICelera
Cytogenetic Map16B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

References

Additional References at PubMed
PMID:2338490   PMID:2419341   PMID:3279416   PMID:7671812   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479  
PMID:15489334   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:22692683   PMID:24457600   PMID:25044020   PMID:26059768   PMID:27113764  
PMID:28106071   PMID:28378742   PMID:30457570   PMID:32968282  


Genomics

Comparative Map Data
Umps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,775,152 - 33,787,408 (-)NCBIGRCm39mm39
GRCm381633,954,782 - 33,967,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,954,782 - 33,967,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371633,955,098 - 33,967,089 (-)NCBIGRCm37mm9NCBIm37
MGSCv361633,874,759 - 33,886,750 (-)NCBImm8
Celera1634,439,142 - 34,451,132 (-)NCBICelera
Cytogenetic Map16B3NCBI
UMPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3124,730,433 - 124,749,273 (+)EnsemblGRCh38hg38GRCh38
GRCh383124,730,442 - 124,749,273 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373124,449,299 - 124,468,120 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh373124,449,213 - 124,468,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363125,931,903 - 125,946,318 (+)NCBINCBI36hg18NCBI36
Build 343125,931,902 - 125,946,318NCBI
Celera3122,856,384 - 122,875,279 (+)NCBI
Cytogenetic Map3q21.2NCBI
HuRef3121,823,485 - 121,842,386 (+)NCBIHuRef
CHM1_13124,412,201 - 124,431,088 (+)NCBICHM1_1
Umps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,806,107 - 66,816,520 (+)NCBI
Rnor_6.0 Ensembl1170,034,139 - 70,044,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01170,034,181 - 70,044,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01173,123,827 - 73,134,236 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,619,835 - 68,630,244 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11168,677,423 - 68,687,833 (+)NCBI
Celera1166,256,748 - 66,267,157 (+)NCBICelera
Cytogenetic Map11q22NCBI
Umps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542723,825,523 - 23,841,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542723,825,529 - 23,841,427 (+)NCBIChiLan1.0ChiLan1.0
UMPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13128,731,309 - 128,745,241 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,731,355 - 128,745,029 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03121,832,758 - 121,851,707 (+)NCBIMhudiblu_PPA_v0panPan3
UMPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3327,754,643 - 27,782,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13327,754,592 - 27,782,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Umps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936725553,278 - 564,846 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,610,058 - 135,650,604 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113135,611,857 - 135,650,656 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213145,113,405 - 145,154,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UMPS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12256,081,897 - 56,097,164 (-)NCBI
ChlSab1.1 Ensembl2256,082,103 - 56,097,105 (-)Ensembl
Umps
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624731761,235 - 780,355 (+)NCBI

Position Markers
AA408257  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381633,954,922 - 33,955,017UniSTSGRCm38
MGSCv371633,955,008 - 33,955,103UniSTSGRCm37
Celera1634,439,052 - 34,439,147UniSTS
Cytogenetic Map16B3UniSTS
Whitehead/MRC_RH16333.39UniSTS
BB164745  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381633,955,070 - 33,955,156UniSTSGRCm38
MGSCv371633,955,156 - 33,955,242UniSTSGRCm37
Celera1634,439,200 - 34,439,286UniSTS
Cytogenetic Map16B3UniSTS
Whitehead/MRC_RH16333.68UniSTS
RH124201  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381633,956,666 - 33,956,789UniSTSGRCm38
MGSCv371633,956,752 - 33,956,875UniSTSGRCm37
Celera1634,440,796 - 34,440,919UniSTS
Cytogenetic Map16B3UniSTS
RH124692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381633,954,924 - 33,955,017UniSTSGRCm38
MGSCv371633,955,010 - 33,955,103UniSTSGRCm37
Celera1634,439,054 - 34,439,147UniSTS
Cytogenetic Map16B3UniSTS
UniSTS:237497  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381633,955,274 - 33,955,412UniSTSGRCm38
MGSCv371633,955,360 - 33,955,498UniSTSGRCm37
Celera1634,439,404 - 34,439,542UniSTS
Cytogenetic Map16B3UniSTS
Umps  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B3UniSTS
cM Map1624.26UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162897245062972589Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162897245062972589Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162897245062972589Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162897245062972589Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163158368336719911Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163249243266492570Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3270409165669666Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1459
Count of miRNA genes:581
Interacting mature miRNAs:668
Transcripts:ENSMUST00000023510, ENSMUST00000131990
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001348087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC165079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM219105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023510   ⟹   ENSMUSP00000023510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1633,954,782 - 33,967,038 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131990   ⟹   ENSMUSP00000119423
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1633,954,794 - 33,967,003 (-)Ensembl
RefSeq Acc Id: NM_001348087   ⟹   NP_001335016
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391633,775,152 - 33,787,408 (-)NCBI
GRCm381633,954,782 - 33,967,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009471   ⟹   NP_033497
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391633,775,152 - 33,787,408 (-)NCBI
GRCm381633,954,782 - 33,967,038 (-)NCBI
MGSCv371633,955,098 - 33,967,089 (-)RGD
Celera1634,439,142 - 34,451,132 (-)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033497   ⟸   NM_009471
- Peptide Label: isoform 1
- UniProtKB: P13439 (UniProtKB/Swiss-Prot),   Q544K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335016   ⟸   NM_001348087
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000119423   ⟸   ENSMUST00000131990
RefSeq Acc Id: ENSMUSP00000023510   ⟸   ENSMUST00000023510
Protein Domains
OMPdecase

Promoters
RGD ID:6827615
Promoter ID:MM_KWN:20835
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000065699,   OTTMUST00000065700
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361633,966,906 - 33,967,412 (-)MPROMDB
RGD ID:8686050
Promoter ID:EPDNEW_M21056
Type:initiation region
Name:Umps_1
Description:Mus musculus uridine monophosphate synthetase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381633,967,003 - 33,967,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1298388 AgrOrtholog
Ensembl Genes ENSMUSG00000022814 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023510 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000119423 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023510 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131990 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OMPdecase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OMPdecase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OMPdeCOase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Or_phspho_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RibuloseP-bd_barrel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22247 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1298388 ENTREZGENE
NCBI Gene 22247 ENTREZGENE
Pfam OMPdecase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UMPS RGD
PhenoGen Umps PhenoGen
PROSITE OMPDECASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PUR_PYR_PR_TRANSFER UniProtKB/Swiss-Prot
SMART OMPdecase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pyrE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  pyrF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RJ62_MOUSE UniProtKB/TrEMBL
  P13439 ENTREZGENE
  Q3TVV7_MOUSE UniProtKB/TrEMBL
  Q544K9 ENTREZGENE, UniProtKB/TrEMBL
  UMPS_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99L26 UniProtKB/Swiss-Prot