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Gene: IQGAP1 (IQ motif containing GTPase activating protein 1) Homo sapiens
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Symbol: IQGAP1
Name: IQ motif containing GTPase activating protein 1
Description: Exhibits several functions, including S100 protein binding activity; calmodulin binding activity; and enzyme binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; neuron projection extension; and positive regulation of protein phosphorylation. Localizes to several cellular components, including extrinsic component of cytoplasmic side of plasma membrane; midbody; and ruffle. Predicted to colocalize with actin cytoskeleton and microtubule cytoskeleton.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HUMORFA01; KIAA0051; p195; ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1
Orthologs:
Mus musculus (house mouse) : Iqgap1 (IQ motif containing GTPase activating protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Iqgap1 (IQ motif containing GTPase activating protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iqgap1 (IQ motif containing GTPase activating protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IQGAP1 (IQ motif containing GTPase activating protein 1)
Canis lupus familiaris (dog) : IQGAP1 (IQ motif containing GTPase activating protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iqgap1 (IQ motif containing GTPase activating protein 1)
Sus scrofa (pig) : IQGAP1 (IQ motif containing GTPase activating protein 1)
Heterocephalus glaber (naked mole-rat) : Iqgap1 (IQ motif containing GTPase activating protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,388,242 - 90,502,239 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,388,242 - 90,502,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,931,473 - 91,045,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,732,477 - 88,846,479 (+)NCBINCBI36hg18NCBI36
Build 341588,732,476 - 88,846,479NCBI
Celera1567,336,216 - 67,450,214 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,043,721 - 67,156,752 (+)NCBIHuRef
CHM1_11590,773,219 - 90,887,196 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on IQGAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323573
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.