Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Laptm4b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LAPTM4B mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Laptm4b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LAPTM4B mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of LAPTM4B mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAPTM4B mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAPTM4B mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Laptm4b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAPTM4B mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of LAPTM4B mRNA | CTD | PMID:30851411 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | 3 more ... | CTD | PMID:23196670 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of LAPTM4B mRNA | CTD | PMID:26251327 | 3-chloropropane-1,2-diol | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | alpha-Chlorohydrin results in decreased expression of LAPTM4B mRNA | CTD | PMID:28522335 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of LAPTM4B mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Fenretinide results in decreased expression of LAPTM4B mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | affects expression | EXP | | 6480464 | Decitabine affects the expression of LAPTM4B mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of LAPTM4B mRNA | CTD | PMID:24780913 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of LAPTM4B mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of LAPTM4B mRNA | CTD | PMID:23724009 and PMID:33167477 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of LAPTM4B mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of LAPTM4B mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of LAPTM4B promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of LAPTM4B mRNA | CTD | PMID:26063408 | bisphenol A | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | bisphenol A results in increased expression of LAPTM4B mRNA and bisphenol A results in increased expression of LAPTM4B protein | CTD | PMID:35479511 | bisphenol A | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LAPTM4B mRNA | CTD | PMID:34947998 | bisphenol A | increases methylation | ISO | Laptm4b (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of LAPTM4B gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of LAPTM4B mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Laptm4b (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of LAPTM4B mRNA | CTD | PMID:26496021 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of LAPTM4B mRNA | CTD | PMID:18560533 | chloropicrin | affects expression | EXP | | 6480464 | chloropicrin affects the expression of LAPTM4B mRNA | CTD | PMID:26352163 | cisplatin | affects response to substance | EXP | | 6480464 | LAPTM4B protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of LAPTM4B mRNA | CTD | PMID:27392435 | cisplatin | affects expression | EXP | | 6480464 | Cisplatin affects the expression of LAPTM4B mRNA | CTD | PMID:23300844 | clobetasol | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Clobetasol results in increased expression of LAPTM4B mRNA | CTD | PMID:27462272 | copper atom | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of LAPTM4B mRNA | CTD | PMID:20971185 | copper atom | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Copper results in increased expression of LAPTM4B mRNA | CTD | PMID:17205981 | copper(0) | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of LAPTM4B mRNA | CTD | PMID:20971185 | copper(0) | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Copper results in increased expression of LAPTM4B mRNA | CTD | PMID:17205981 | crocidolite asbestos | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of LAPTM4B mRNA | CTD | PMID:29279043 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of LAPTM4B mRNA | CTD | PMID:20106945 and PMID:27989131 | diuron | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of LAPTM4B mRNA | CTD | PMID:21551480 | doxorubicin | affects expression | EXP | | 6480464 | Doxorubicin affects the expression of LAPTM4B mRNA | CTD | PMID:29803840 | ethanol | affects splicing | ISO | Laptm4b (Mus musculus) | 6480464 | Ethanol affects the splicing of LAPTM4B mRNA | CTD | PMID:30319688 | folic acid | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Folic Acid results in decreased expression of LAPTM4B mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Laptm4b (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LAPTM4B mRNA | CTD | PMID:22206623 | ketamine | increases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Ketamine results in increased expression of LAPTM4B mRNA | CTD | PMID:20080153 | methoxychlor | affects methylation | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of LAPTM4B gene | CTD | PMID:35440735 | nimesulide | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | nimesulide results in decreased expression of LAPTM4B mRNA | CTD | PMID:24136188 | oxaliplatin | multiple interactions | ISO | Laptm4b (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of LAPTM4B mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LAPTM4B mRNA | CTD | PMID:29067470 | paracetamol | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of LAPTM4B mRNA | CTD | PMID:33387578 | pentachlorophenol | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of LAPTM4B mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Laptm4b (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LAPTM4B mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of LAPTM4B mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of LAPTM4B mRNA | CTD | PMID:19159669 | PhIP | increases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of LAPTM4B mRNA | CTD | PMID:15215175 | pirinixic acid | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of LAPTM4B mRNA | CTD | PMID:17426115 | pirinixic acid | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | pirinixic acid results in increased expression of LAPTM4B mRNA | CTD | PMID:23811191 | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of LAPTM4B mRNA | CTD | PMID:30851411 | rotenone | increases expression | ISO | Laptm4b (Mus musculus) | 6480464 | Rotenone results in increased expression of LAPTM4B mRNA | CTD | PMID:23186747 | temozolomide | increases expression | EXP | | 6480464 | Temozolomide results in increased expression of LAPTM4B mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | ISO | Laptm4b (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of LAPTM4B mRNA | CTD | PMID:26496021 | tetrachloromethane | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of LAPTM4B mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of LAPTM4B mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of LAPTM4B mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | ISO | Laptm4b (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of LAPTM4B mRNA | CTD | PMID:25729387 | triclosan | decreases expression | EXP | | 6480464 | Triclosan results in decreased expression of LAPTM4B mRNA | CTD | PMID:30510588 | trimellitic anhydride | decreases expression | ISO | Laptm4b (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of LAPTM4B mRNA | CTD | PMID:19042947 | trovafloxacin | decreases expression | ISO | Laptm4b (Rattus norvegicus) | 6480464 | trovafloxacin results in decreased expression of LAPTM4B mRNA | CTD | PMID:24136188 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of LAPTM4B mRNA | CTD | PMID:23179753 and PMID:29154799 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of LAPTM4B mRNA | CTD | PMID:25979313 | |