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Gene: ORC2 (origin recognition complex subunit 2) Homo sapiens
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Symbol: ORC2
Name: origin recognition complex subunit 2
Description: Predicted to have DNA replication origin binding activity. Predicted to be involved in DNA replication initiation; G1/S transition of mitotic cell cycle; and negative regulation of transcription by RNA polymerase II. Localizes to the centrosome; heterochromatin; and nuclear lumen. Colocalizes with the nuclear chromosome, telomeric region.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ORC2L; origin of replication 2-like; origin recognition complex protein 2 homolog; origin recognition complex, subunit 2 homolog; origin recognition complex, subunit 2-like
Orthologs:
Mus musculus (house mouse) : Orc2 (origin recognition complex, subunit 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Orc2 (origin recognition complex, subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Orc2 (origin recognition complex subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ORC2 (origin recognition complex subunit 2)
Canis lupus familiaris (dog) : ORC2 (origin recognition complex subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Orc2 (origin recognition complex subunit 2)
Sus scrofa (pig) : ORC2 (origin recognition complex subunit 2)
Chlorocebus sabaeus (green monkey) : ORC2 (origin recognition complex subunit 2)
Heterocephalus glaber (naked mole-rat) : Orc2 (origin recognition complex subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2200,908,977 - 200,963,680 (-)Ensembl
GRCh382200,908,977 - 200,963,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372201,774,894 - 201,828,424 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,483,139 - 201,536,655 (-)NCBINCBI36hg18NCBI36
Build 342201,600,400 - 201,653,916NCBI
Celera2195,529,524 - 195,583,050 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,626,266 - 193,679,712 (-)NCBIHuRef
CHM1_12201,780,893 - 201,834,423 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ORC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323514
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.