Prss37 (serine protease 37) - Rat Genome Database

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Gene: Prss37 (serine protease 37) Mus musculus
Analyze
Symbol: Prss37
Name: serine protease 37
RGD ID: 1323481
MGI Page MGI
Description: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Involved in positive regulation of fertilization. Acts upstream of or within binding activity of sperm to zona pellucida; germ cell migration; and protein maturation. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle and extracellular space. Orthologous to human PRSS37 (serine protease 37).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700016G05Rik; probable inactive serine protease 37; probable inactive trypsin-X2; protease, serine 37; protease, serine, 37; Tryx2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,757 - 40,496,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)EnsemblGRCm39 Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBIMGSCv36mm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:23553430   PMID:25921412   PMID:34028541   PMID:35471551  


Genomics

Comparative Map Data
Prss37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,757 - 40,496,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)EnsemblGRCm39 Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBIMGSCv36mm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
PRSS37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387141,836,278 - 141,841,485 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7141,836,300 - 141,841,487 (-)EnsemblGRCh38hg38GRCh38
GRCh377141,536,078 - 141,541,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,182,555 - 141,187,690 (-)NCBINCBI36Build 36hg18NCBI36
Celera7136,257,527 - 136,262,670 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7135,832,747 - 135,837,890 (-)NCBIHuRef
CHM1_17141,470,427 - 141,475,570 (-)NCBICHM1_1
T2T-CHM13v2.07143,152,100 - 143,157,307 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)NCBI
Prss37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,289,678 - 70,301,259 (-)NCBIGRCr8
mRatBN7.2469,322,977 - 69,334,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,322,977 - 69,334,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx474,251,277 - 74,262,855 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0470,172,430 - 70,184,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0468,590,926 - 68,602,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0468,337,498 - 68,349,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl468,337,480 - 68,349,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,126,537 - 133,140,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,086,470 - 68,101,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1468,362,599 - 68,377,199 (-)NCBI
Celera464,325,342 - 64,336,751 (-)NCBICelera
Cytogenetic Map4q23NCBI
Prss37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,744,044 - 1,747,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,742,104 - 1,747,310 (+)NCBIChiLan1.0ChiLan1.0
PRSS37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26178,624,886 - 178,630,383 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1730,635,141 - 30,640,638 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07133,767,802 - 133,773,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,236,906 - 146,242,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,236,906 - 146,242,157 (-)Ensemblpanpan1.1panPan2
PRSS37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,379,344 - 7,385,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,300,899 - 7,306,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBIUU_Cfam_GSD_1.0
Prss37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,537,705 - 13,542,968 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365925,676,944 - 5,680,479 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365925,676,944 - 5,681,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,111,692 - 8,118,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,112,288 - 8,119,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,207,603 - 8,214,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,583,991 - 110,588,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,584,109 - 110,588,046 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,262,134 - 7,266,660 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,837,894 - 21,844,400 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,838,292 - 21,844,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss37
214 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:234
Interacting mature miRNAs:242
Transcripts:ENSMUST00000031967, ENSMUST00000148195
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031967   ⟹   ENSMUSP00000031967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,491,758 - 40,496,442 (-)Ensembl
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,496,103 - 40,496,417 (-)Ensembl
GRCm38.p6 Ensembl640,519,169 - 40,519,483 (-)Ensembl
RefSeq Acc Id: NM_001417656   ⟹   NP_001404585
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,491,757 - 40,496,418 (-)NCBI
RefSeq Acc Id: NM_026317   ⟹   NP_080593
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,491,757 - 40,496,418 (-)NCBI
GRCm38640,514,824 - 40,519,508 (-)NCBI
MGSCv37640,464,823 - 40,469,507 (-)RGD
Celera640,502,240 - 40,506,924 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080593   ⟸   NM_026317
- Peptide Label: precursor
- UniProtKB: Q9CUH3 (UniProtKB/Swiss-Prot),   Q9DAA4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031967   ⟸   ENSMUST00000031967
RefSeq Acc Id: NP_001404585   ⟸   NM_001417656
- Peptide Label: precursor
- UniProtKB: Q9DAA4 (UniProtKB/Swiss-Prot),   Q9CUH3 (UniProtKB/Swiss-Prot)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DAA4-F1-model_v2 AlphaFold Q9DAA4 1-237 view protein structure

Promoters
RGD ID:6889424
Promoter ID:EPDNEW_M8163
Type:multiple initiation site
Name:Prss37_1
Description:Mus musculus protease, serine 37 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38640,519,484 - 40,519,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914940 AgrOrtholog
Ensembl Genes ENSMUSG00000029909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031967 ENTREZGENE
  ENSMUST00000031967.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
KEGG Report mmu:67690 UniProtKB/Swiss-Prot
MGD MGI:1914940 ENTREZGENE
NCBI Gene 67690 ENTREZGENE
PANTHER INACTIVE SERINE PROTEASE 37-RELATED UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss37 PhenoGen
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt PRS37_MOUSE UniProtKB/Swiss-Prot
  Q9CUH3 ENTREZGENE
  Q9DAA4 ENTREZGENE
UniProt Secondary Q9CUH3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss37  serine protease 37  Prss37  protease, serine 37  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss37  protease, serine 37    protease, serine, 37  Symbol and/or name change 5135510 APPROVED