Prss37 (protease, serine 37) - Rat Genome Database

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Gene: Prss37 (protease, serine 37) Mus musculus
Analyze
Symbol: Prss37
Name: protease, serine 37
RGD ID: 1323481
MGI Page MGI
Description: Predicted to have metal ion binding activity and serine-type endopeptidase activity. Involved in several processes, including binding activity of sperm to zona pellucida; positive regulation of fertilization; and protein maturation. Predicted to localize to acrosomal vesicle and intracellular membrane-bounded organelle. Orthologous to human PRSS37 (serine protease 37); INTERACTS WITH 1,2-dimethylhydrazine; titanium dioxide; benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1700016G05Rik; probable inactive serine protease 37; probable inactive trypsin-X2; protease, serine, 37; Tryx2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,754 - 40,496,469 (-)NCBIGRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBImm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:23553430   PMID:25921412  


Genomics

Comparative Map Data
Prss37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,491,754 - 40,496,469 (-)NCBIGRCm39mm39
GRCm39 Ensembl640,491,758 - 40,496,442 (-)Ensembl
GRCm38640,514,820 - 40,519,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,464,823 - 40,469,507 (-)NCBIGRCm37mm9NCBIm37
MGSCv36640,444,431 - 40,449,113 (-)NCBImm8
Celera640,502,240 - 40,506,924 (-)NCBICelera
Cytogenetic Map6B1NCBI
PRSS37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7141,836,300 - 141,841,487 (-)EnsemblGRCh38hg38GRCh38
GRCh387141,836,278 - 141,849,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,536,078 - 141,541,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,182,555 - 141,187,690 (-)NCBINCBI36hg18NCBI36
Celera7136,257,527 - 136,262,670 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7135,832,747 - 135,837,890 (-)NCBIHuRef
CHM1_17141,470,427 - 141,475,570 (-)NCBICHM1_1
CRA_TCAGchr7v27140,873,792 - 140,878,935 (-)NCBI
Prss37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2469,322,977 - 69,334,555 (-)NCBI
Rnor_6.0 Ensembl468,337,480 - 68,349,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0468,337,498 - 68,349,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04133,126,537 - 133,140,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,086,470 - 68,101,076 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1468,362,599 - 68,377,199 (-)NCBI
Celera464,325,342 - 64,336,751 (-)NCBICelera
Cytogenetic Map4q22NCBI
Prss37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,744,044 - 1,747,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,742,104 - 1,747,310 (+)NCBIChiLan1.0ChiLan1.0
PRSS37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17146,236,906 - 146,242,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,236,906 - 146,242,157 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07133,767,802 - 133,773,321 (-)NCBIMhudiblu_PPA_v0panPan3
PRSS37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,379,344 - 7,385,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,379,830 - 7,385,159 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,224,008 - 8,229,814 (+)NCBI
ROS_Cfam_1.0167,300,896 - 7,306,702 (+)NCBI
UMICH_Zoey_3.1167,254,225 - 7,260,030 (+)NCBI
UNSW_CanFamBas_1.0167,096,603 - 7,102,409 (+)NCBI
UU_Cfam_GSD_1.0167,164,356 - 7,170,162 (+)NCBI
Prss37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,537,705 - 13,542,968 (+)NCBI
SpeTri2.0NW_0049365925,676,944 - 5,681,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,111,850 - 8,118,681 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,112,288 - 8,119,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,207,603 - 8,214,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,583,991 - 110,588,985 (-)NCBI
ChlSab1.1 Ensembl21110,584,109 - 110,588,046 (-)Ensembl
Vero_WHO_p1.0NW_0236660727,262,134 - 7,266,660 (-)NCBI
Prss37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476521,838,292 - 21,844,887 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61773466351734784Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63389528167895420Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61773466351734784Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122246751334Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707543297169Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3676447870764478Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63629634770296450Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63647147170471591Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1773466351734784Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122246751334Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797246118070Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62007289554072895Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3172656565726677Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2831405962314181Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62380000057800000Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63270000066700000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345314181Mouse
11252142Mom12_mModifier of Min 12 (mouse)63389528167895420Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61770000053500000Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61963941153639411Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61963941153639411Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61963941153639411Mouse
14746995Manh60_mmandible shape 60 (mouse)63722567771225677Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:234
Interacting mature miRNAs:242
Transcripts:ENSMUST00000031967, ENSMUST00000148195
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031967   ⟹   ENSMUSP00000031967
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl640,514,824 - 40,519,508 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148195
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl640,519,169 - 40,519,483 (-)Ensembl
RefSeq Acc Id: NM_026317   ⟹   NP_080593
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,491,758 - 40,496,442 (-)NCBI
GRCm38640,514,824 - 40,519,508 (-)NCBI
MGSCv37640,464,823 - 40,469,507 (-)RGD
Celera640,502,240 - 40,506,924 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506525   ⟹   XP_006506588
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,491,754 - 40,496,469 (-)NCBI
GRCm38640,514,820 - 40,519,535 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080593   ⟸   NM_026317
- Peptide Label: precursor
- UniProtKB: Q9DAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506588   ⟸   XM_006506525
- Peptide Label: isoform X1
- UniProtKB: Q9DAA4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031967   ⟸   ENSMUST00000031967
Protein Domains
Peptidase S1

Promoters
RGD ID:6889424
Promoter ID:EPDNEW_M8163
Type:multiple initiation site
Name:Prss37_1
Description:Mus musculus protease, serine 37 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38640,519,484 - 40,519,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914940 AgrOrtholog
Ensembl Genes ENSMUSG00000029909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000031967 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031967 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
KEGG Report mmu:67690 UniProtKB/Swiss-Prot
MGD MGI:1914940 ENTREZGENE
NCBI Gene 67690 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss37 PhenoGen
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt PRS37_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9CUH3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Prss37  protease, serine 37    protease, serine, 37  Symbol and/or name change 5135510 APPROVED