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Gene: MRPL4 (mitochondrial ribosomal protein L4) Homo sapiens
Symbol: MRPL4
Name: mitochondrial ribosomal protein L4
Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 39S ribosomal protein L4, mitochondrial; CGI-28; L4mt; MGC16367; MGC2681; mitochondrial large ribosomal subunit protein uL4m; MRP-L4
Mus musculus (house mouse) : Mrpl4 (mitochondrial ribosomal protein L4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mrpl4 (mitochondrial ribosomal protein L4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mrpl4 (mitochondrial ribosomal protein L4)
Pan paniscus (bonobo/pygmy chimpanzee) : MRPL4 (mitochondrial ribosomal protein L4)
Canis lupus familiaris (dog) : MRPL4 (mitochondrial ribosomal protein L4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mrpl4 (mitochondrial ribosomal protein L4)
Sus scrofa (pig) : MRPL4 (mitochondrial ribosomal protein L4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,251,962 - 10,260,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,362,640 - 10,370,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,223,640 - 10,231,736 (+)NCBINCBI36hg18NCBI36
Build 341910,223,639 - 10,231,736NCBI
Celera1910,258,038 - 10,266,134 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,942,881 - 9,950,978 (+)NCBIHuRef
CHM1_11910,362,919 - 10,371,000 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MRPL4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323408
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.