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Gene: MRPL4 (mitochondrial ribosomal protein L4) Homo sapiens
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Symbol: MRPL4
Name: mitochondrial ribosomal protein L4
Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 39S ribosomal protein L4, mitochondrial; CGI-28; L4mt; MGC16367; MGC2681; mitochondrial large ribosomal subunit protein uL4m; MRP-L4
Orthologs:
Mus musculus (house mouse) : Mrpl4 (mitochondrial ribosomal protein L4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mrpl4 (mitochondrial ribosomal protein L4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mrpl4 (mitochondrial ribosomal protein L4)
Pan paniscus (bonobo/pygmy chimpanzee) : MRPL4 (mitochondrial ribosomal protein L4)
Canis lupus familiaris (dog) : MRPL4 (mitochondrial ribosomal protein L4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mrpl4 (mitochondrial ribosomal protein L4)
Sus scrofa (pig) : MRPL4 (mitochondrial ribosomal protein L4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,251,962 - 10,260,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,362,640 - 10,370,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,223,640 - 10,231,736 (+)NCBINCBI36hg18NCBI36
Build 341910,223,639 - 10,231,736NCBI
Celera1910,258,038 - 10,266,134 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,942,881 - 9,950,978 (+)NCBIHuRef
CHM1_11910,362,919 - 10,371,000 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MRPL4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323408
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.