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Gene: RFX5 (regulatory factor X5) Homo sapiens
Symbol: RFX5
Name: regulatory factor X5
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Localizes to transcription regulator complex. Implicated in MHC class II deficiency and severe combined immunodeficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA-binding protein RFX5; regulatory factor X 5; regulatory factor X, 5 (influences HLA class II expression)
Mus musculus (house mouse) : Rfx5 (regulatory factor X, 5 (influences HLA class II expression))  MGI  Alliance
Rattus norvegicus (Norway rat) : Rfx5 (regulatory factor X5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfx5 (regulatory factor X5)
Pan paniscus (bonobo/pygmy chimpanzee) : RFX5 (regulatory factor X5)
Canis lupus familiaris (dog) : RFX5 (regulatory factor X5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfx5 (regulatory factor X5)
Sus scrofa (pig) : RFX5 (regulatory factor X5)
Chlorocebus sabaeus (African green monkey) : RFX5 (regulatory factor X5)
Heterocephalus glaber (naked mole-rat) : Rfx5 (regulatory factor X5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1151,340,640 - 151,347,357 (-)EnsemblGRCh38hg38GRCh38
GRCh381151,340,640 - 151,347,319 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371151,313,116 - 151,319,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,579,740 - 149,586,393 (-)NCBINCBI36hg18NCBI36
Build 341148,126,189 - 148,132,773NCBI
Celera1124,428,407 - 124,435,060 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,691,259 - 122,697,912 (-)NCBIHuRef
CHM1_11152,708,791 - 152,715,444 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RFX5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323259
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.