DAPK1 (death associated protein kinase 1) - Rat Genome Database
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Gene: DAPK1 (death associated protein kinase 1) Homo sapiens
Analyze
Symbol: DAPK1
Name: death associated protein kinase 1
RGD ID: 1323186
HGNC Page HGNC
Description: Exhibits several functions, including ATP binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including cellular response to hydroperoxide; cellular response to interferon-gamma; and regulation of cellular protein metabolic process. Localizes to actin cytoskeleton; cytoplasm; and plasma membrane. Implicated in urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DAP kinase 1; DAPK; death-associated protein kinase 1; DKFZp781I035; ROCO3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100420576  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,497,228 - 87,708,634 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,497,228 - 87,708,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,112,601 - 90,323,566 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37990,112,143 - 90,323,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,302,576 - 89,513,369 (+)NCBINCBI36hg18NCBI36
Build 34987,342,349 - 87,553,097NCBI
Celera960,684,038 - 60,893,765 (+)NCBI
Cytogenetic Map9q21.33ENTREZGENE
HuRef959,938,084 - 60,147,991 (+)NCBIHuRef
CHM1_1990,259,940 - 90,471,316 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Brevetoxin B  (EXP)
buspirone  (ISO)
butanal  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
chelidonine  (EXP)
chloroprene  (ISO)
cholesterol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
dimethylarsinous acid  (EXP)
disodium selenite  (EXP)
doxifluridine  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
flutamide  (ISO)
glycine betaine  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
hydroxyurea  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
mitoxantrone  (EXP)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nevirapine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nimesulide  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentanal  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
vorinostat  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IDA)
cytoplasm  (IBA,IDA,ISO)
nucleus  (IBA)
plasma membrane  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7828849   PMID:8889549   PMID:10629061   PMID:11485996   PMID:11579085   PMID:11809677   PMID:12031912   PMID:12082610   PMID:12351649   PMID:12370243   PMID:12477932   PMID:12708480  
PMID:12730201   PMID:12792765   PMID:12820391   PMID:12911633   PMID:14504087   PMID:14530257   PMID:14612952   PMID:14767518   PMID:15001356   PMID:15018706   PMID:15048887   PMID:15146197  
PMID:15342556   PMID:15492995   PMID:15616583   PMID:15634757   PMID:15729359   PMID:15809761   PMID:16085644   PMID:16132846   PMID:16142356   PMID:16213824   PMID:16344560   PMID:16756490  
PMID:16847012   PMID:16858683   PMID:16951219   PMID:17056602   PMID:17209433   PMID:17244621   PMID:17319784   PMID:17324927   PMID:17324930   PMID:17339337   PMID:17477876   PMID:17523078  
PMID:17540169   PMID:17592394   PMID:17683884   PMID:17690039   PMID:17703233   PMID:17868341   PMID:17895359   PMID:17953697   PMID:18026971   PMID:18195017   PMID:18292548   PMID:18336955  
PMID:18349282   PMID:18422656   PMID:18425396   PMID:18519826   PMID:18583991   PMID:18799028   PMID:18813964   PMID:18830724   PMID:18974095   PMID:18995835   PMID:19018866   PMID:19094228  
PMID:19148529   PMID:19180116   PMID:19196380   PMID:19212339   PMID:19237746   PMID:19259700   PMID:19267229   PMID:19272801   PMID:19395874   PMID:19506903   PMID:19521987   PMID:19627511  
PMID:19695681   PMID:19712061   PMID:19778817   PMID:19795445   PMID:19878310   PMID:19917631   PMID:19957692   PMID:20005690   PMID:20018188   PMID:20098747   PMID:20103772   PMID:20220139  
PMID:20360646   PMID:20379614   PMID:20389280   PMID:20413850   PMID:20471512   PMID:20514412   PMID:20534741   PMID:20574532   PMID:20630662   PMID:20655775   PMID:20677014   PMID:20682398  
PMID:20704749   PMID:20811724   PMID:21115918   PMID:21134130   PMID:21152427   PMID:21152877   PMID:21159370   PMID:21167819   PMID:21172653   PMID:21176336   PMID:21212658   PMID:21287504  
PMID:21302620   PMID:21311567   PMID:21353277   PMID:21497122   PMID:21516484   PMID:21725354   PMID:21738225   PMID:21749573   PMID:21797120   PMID:21873635   PMID:21918973   PMID:21922274  
PMID:21965790   PMID:21979297   PMID:22087225   PMID:22095288   PMID:22096027   PMID:22116316   PMID:22136354   PMID:22160140   PMID:22230750   PMID:22293537   PMID:22371043   PMID:22420243  
PMID:22465880   PMID:22490852   PMID:22490855   PMID:22549447   PMID:22552543   PMID:22610502   PMID:22785394   PMID:22827846   PMID:22988864   PMID:23175185   PMID:23245584   PMID:23275143  
PMID:23383130   PMID:23494221   PMID:23545262   PMID:23702034   PMID:23800064   PMID:23804521   PMID:23806751   PMID:23948915   PMID:24071855   PMID:24188325   PMID:24314662   PMID:24337450  
PMID:24531619   PMID:24559316   PMID:24684796   PMID:24811488   PMID:24814955   PMID:24853415   PMID:24877104   PMID:24954895   PMID:25135476   PMID:25229255   PMID:25241761   PMID:25268905  
PMID:25380824   PMID:25496179   PMID:25550789   PMID:25619834   PMID:25848215   PMID:25852190   PMID:25963636   PMID:26075823   PMID:26100670   PMID:26165472   PMID:26186194   PMID:26191186  
PMID:26213212   PMID:26267895   PMID:26405175   PMID:26406950   PMID:26582930   PMID:26626260   PMID:26810771   PMID:26823825   PMID:27068745   PMID:27085326   PMID:27094130   PMID:27286455  
PMID:27452040   PMID:27590344   PMID:27609421   PMID:27622827   PMID:27633052   PMID:27803151   PMID:27907054   PMID:27930338   PMID:28132841   PMID:28169274   PMID:28231808   PMID:28249042  
PMID:28324774   PMID:28339067   PMID:28361856   PMID:28388658   PMID:28412611   PMID:28429084   PMID:28429233   PMID:28514442   PMID:28614711   PMID:28858643   PMID:28934284   PMID:29317503  
PMID:29480000   PMID:29513927   PMID:29578152   PMID:29775889   PMID:29807777   PMID:30021884   PMID:30460377   PMID:30575818   PMID:30639242   PMID:30664712   PMID:30718039   PMID:30911150  
PMID:30912402   PMID:30999631   PMID:31093876   PMID:31116076   PMID:31279627   PMID:31563554   PMID:31772156   PMID:31978714   PMID:32355040   PMID:32449268   PMID:32867455  


Genomics

Comparative Map Data
DAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,497,228 - 87,708,634 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,497,228 - 87,708,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,112,601 - 90,323,566 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37990,112,143 - 90,323,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,302,576 - 89,513,369 (+)NCBINCBI36hg18NCBI36
Build 34987,342,349 - 87,553,097NCBI
Celera960,684,038 - 60,893,765 (+)NCBI
Cytogenetic Map9q21.33ENTREZGENE
HuRef959,938,084 - 60,147,991 (+)NCBIHuRef
CHM1_1990,259,940 - 90,471,316 (+)NCBICHM1_1
Dapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,749,506 - 60,911,005 (+)NCBIGRCm39mm39
GRCm381360,601,723 - 60,763,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,601,947 - 60,763,191 (+)EnsemblGRCm38mm10GRCm38
MGSCv371360,703,308 - 60,864,547 (+)NCBIGRCm37mm9NCBIm37
MGSCv361360,612,049 - 60,772,424 (+)NCBImm8
Celera1361,661,141 - 61,823,107 (+)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.53NCBI
Dapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2173,930,223 - 4,090,991 (-)NCBI
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0174,297,038 - 4,454,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0176,525,247 - 6,683,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,617,607 - 9,779,457 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,617,606 - 9,779,457 (-)NCBI
Celera174,059,212 - 4,219,046 (-)NCBICelera
Cytogenetic Map17p14NCBI
Dapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543229,197 - 254,379 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543229,925 - 254,327 (-)NCBIChiLan1.0ChiLan1.0
DAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1986,680,202 - 86,887,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,681,953 - 86,887,958 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0958,628,872 - 58,836,205 (+)NCBIMhudiblu_PPA_v0panPan3
DAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl172,280,103 - 72,447,822 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1172,278,939 - 72,448,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366802,842,930 - 3,020,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,724,644 - 27,954,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,724,644 - 27,954,708 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,963,591 - 31,970,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,118,948 - 98,330,435 (+)NCBI
ChlSab1.1 Ensembl1298,118,603 - 98,330,471 (+)Ensembl
Dapk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248099,585,426 - 9,794,582 (-)NCBI

Position Markers
D9S257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,290,742 - 90,291,006UniSTSGRCh37
Build 36989,480,562 - 89,480,826RGDNCBI36
Celera960,860,950 - 60,861,226RGD
Cytogenetic Map9q13-q22UniSTS
Cytogenetic Map9q21.33UniSTS
HuRef960,115,173 - 60,115,449UniSTS
Marshfield Genetic Map991.87UniSTS
Marshfield Genetic Map991.87RGD
Genethon Genetic Map990.6UniSTS
TNG Radiation Hybrid Map932024.0UniSTS
GeneMap99-GB4 RH Map9287.7UniSTS
Whitehead-RH Map9328.7UniSTS
SHGC-33610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,151,266 - 90,151,390UniSTSGRCh37
Build 36989,341,086 - 89,341,210RGDNCBI36
Celera960,722,551 - 60,722,675RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,976,602 - 59,976,726UniSTS
TNG Radiation Hybrid Map931983.0UniSTS
GeneMap99-GB4 RH Map9280.33UniSTS
Whitehead-RH Map9325.6UniSTS
GeneMap99-G3 RH Map92829.0UniSTS
STS-N34470  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,169,069 - 90,169,307UniSTSGRCh37
Build 36989,358,889 - 89,359,127RGDNCBI36
Celera960,740,363 - 60,740,601RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,994,390 - 59,994,628UniSTS
GeneMap99-GB4 RH Map9281.55UniSTS
NCBI RH Map9758.7UniSTS
SHGC-84082  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,254,997 - 90,255,340UniSTSGRCh37
Build 36989,444,817 - 89,445,160RGDNCBI36
Celera960,826,294 - 60,826,637RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,080,080 - 60,080,423UniSTS
TNG Radiation Hybrid Map932031.0UniSTS
G59619  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,133,684 - 90,133,784UniSTSGRCh37
Build 36989,323,504 - 89,323,604RGDNCBI36
Celera960,704,965 - 60,705,065RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,959,014 - 59,959,114UniSTS
TNG Radiation Hybrid Map931919.0UniSTS
D9S316  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,290,688 - 90,290,834UniSTSGRCh37
Build 36989,480,508 - 89,480,654RGDNCBI36
Celera960,860,896 - 60,861,054RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,115,119 - 60,115,277UniSTS
SHGC-146783  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,139,307 - 90,139,497UniSTSGRCh37
Build 36989,329,127 - 89,329,317RGDNCBI36
Celera960,710,588 - 60,710,778RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,964,637 - 59,964,827UniSTS
TNG Radiation Hybrid Map931961.0UniSTS
SHGC-148843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,238,594 - 90,238,888UniSTSGRCh37
Build 36989,428,414 - 89,428,708RGDNCBI36
Celera960,809,891 - 60,810,185RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,063,680 - 60,063,974UniSTS
TNG Radiation Hybrid Map932045.0UniSTS
SHGC-149458  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,287,309 - 90,287,641UniSTSGRCh37
Build 36989,477,129 - 89,477,461RGDNCBI36
Celera960,857,517 - 60,857,849RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,111,742 - 60,112,074UniSTS
TNG Radiation Hybrid Map932024.0UniSTS
D9S2045  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,322,337 - 90,322,457UniSTSGRCh37
Build 36989,512,157 - 89,512,277RGDNCBI36
Celera960,892,553 - 60,892,673RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,146,779 - 60,146,899UniSTS
RH18220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,151,171 - 90,151,337UniSTSGRCh37
Build 36989,340,991 - 89,341,157RGDNCBI36
Celera960,722,456 - 60,722,622RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,976,507 - 59,976,673UniSTS
GeneMap99-GB4 RH Map9279.42UniSTS
NCBI RH Map9761.5UniSTS
DAPK1_7778  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,323,010 - 90,323,667UniSTSGRCh37
Build 36989,512,830 - 89,513,487RGDNCBI36
Celera960,893,226 - 60,893,883RGD
HuRef960,147,452 - 60,148,109UniSTS
WI-17027  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,215,737 - 90,215,887UniSTSGRCh37
Build 36989,405,557 - 89,405,707RGDNCBI36
Celera960,787,038 - 60,787,188RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,040,768 - 60,040,918UniSTS
GeneMap99-GB4 RH Map9280.33UniSTS
Whitehead-RH Map9325.6UniSTS
SHGC-2351  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,323,305 - 90,323,545UniSTSGRCh37
Build 36989,513,125 - 89,513,365RGDNCBI36
Celera960,893,521 - 60,893,761RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,147,747 - 60,147,987UniSTS
GeneMap99-GB4 RH Map9285.36UniSTS
GeneMap99-GB4 RH Map9284.53UniSTS
Whitehead-RH Map9328.7UniSTS
Whitehead-YAC Contig Map9 UniSTS
NCBI RH Map9769.7UniSTS
GeneMap99-G3 RH Map92833.0UniSTS
STS-X76104  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,323,057 - 90,323,203UniSTSGRCh37
Build 36989,512,877 - 89,513,023RGDNCBI36
Celera960,893,273 - 60,893,419RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,147,499 - 60,147,645UniSTS
GeneMap99-GB4 RH Map9283.91UniSTS
RH45604  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,133,623 - 90,133,790UniSTSGRCh37
Build 36989,323,443 - 89,323,610RGDNCBI36
Celera960,704,904 - 60,705,071RGD
Cytogenetic Map9q21.33UniSTS
HuRef959,958,953 - 59,959,120UniSTS
GeneMap99-GB4 RH Map9280.43UniSTS
RH69306  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,297,692 - 90,297,815UniSTSGRCh37
Build 36989,487,512 - 89,487,635RGDNCBI36
Celera960,867,912 - 60,868,035RGD
Cytogenetic Map9q21.33UniSTS
HuRef960,122,135 - 60,122,258UniSTS
GeneMap99-GB4 RH Map9285.16UniSTS
DAPK1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37990,321,592 - 90,321,801UniSTSGRCh37
Celera960,891,808 - 60,892,017UniSTS
HuRef960,146,034 - 60,146,243UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR107hsa-miR-107Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22593189
MIR107hsa-miR-107OncomiRDBexternal_infoNANA22593189
MIR214hsa-miR-214-3pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)19435428
MIR103A1hsa-miR-103a-3pOncomiRDBexternal_infoNANA22593189

Predicted Target Of
Summary Value
Count of predictions:5720
Count of miRNA genes:1315
Interacting mature miRNAs:1706
Transcripts:ENST00000358077, ENST00000408954, ENST00000463069, ENST00000466188, ENST00000468482, ENST00000469067, ENST00000469640, ENST00000470267, ENST00000472284, ENST00000472344, ENST00000475804, ENST00000489291, ENST00000491893, ENST00000494010, ENST00000495182, ENST00000495281, ENST00000496522, ENST00000497743
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2015 408 1213 436 937 312 1273 904 1913 296 860 1384 133 769 654 4
Low 382 2361 507 186 855 152 2962 976 1796 111 578 185 38 1 435 2020 1 1
Below cutoff 19 211 3 1 81 1 118 312 19 11 14 19 114

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005251757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA846231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA854055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB208871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL160279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL161787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG110813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP202018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD642694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN347006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX758421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX872304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA234399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA855348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA887235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC340223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ436495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR002874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF090258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H77515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX533481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X76104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000358077   ⟹   ENSP00000350785
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,228 - 87,708,631 (+)Ensembl
RefSeq Acc Id: ENST00000408954   ⟹   ENSP00000386135
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,867 - 87,708,634 (+)Ensembl
RefSeq Acc Id: ENST00000463069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,639,438 - 87,640,412 (+)Ensembl
RefSeq Acc Id: ENST00000466188
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,657,416 - 87,668,948 (+)Ensembl
RefSeq Acc Id: ENST00000468482
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,698,409 - 87,700,217 (+)Ensembl
RefSeq Acc Id: ENST00000469067
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,736 - 87,650,511 (+)Ensembl
RefSeq Acc Id: ENST00000469640   ⟹   ENSP00000418885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,681 - 87,708,633 (+)Ensembl
RefSeq Acc Id: ENST00000470267
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,912 - 87,499,352 (+)Ensembl
RefSeq Acc Id: ENST00000472284   ⟹   ENSP00000417076
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,681 - 87,708,630 (+)Ensembl
RefSeq Acc Id: ENST00000472344
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,498,611 - 87,639,483 (+)Ensembl
RefSeq Acc Id: ENST00000475804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,648,575 - 87,651,590 (+)Ensembl
RefSeq Acc Id: ENST00000489291   ⟹   ENSP00000417746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,499,006 - 87,707,382 (+)Ensembl
RefSeq Acc Id: ENST00000491893   ⟹   ENSP00000419026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,499,005 - 87,707,382 (+)Ensembl
RefSeq Acc Id: ENST00000494010
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,649,990 - 87,668,047 (+)Ensembl
RefSeq Acc Id: ENST00000495182
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,497,835 - 87,507,002 (+)Ensembl
RefSeq Acc Id: ENST00000495281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,648,586 - 87,650,479 (+)Ensembl
RefSeq Acc Id: ENST00000496522
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,498,535 - 87,638,027 (+)Ensembl
RefSeq Acc Id: ENST00000497743
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,668,453 - 87,681,522 (+)Ensembl
RefSeq Acc Id: ENST00000622514   ⟹   ENSP00000484267
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl987,498,535 - 87,708,633 (+)Ensembl
RefSeq Acc Id: NM_001288729   ⟹   NP_001275658
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,498,582 - 87,708,634 (+)NCBI
HuRef959,937,471 - 60,147,991 (+)NCBI
CHM1_1990,261,247 - 90,471,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288730   ⟹   NP_001275659
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,734 - 87,708,634 (+)NCBI
HuRef959,937,471 - 60,147,991 (+)NCBI
CHM1_1990,260,393 - 90,471,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001288731   ⟹   NP_001275660
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,228 - 87,708,634 (+)NCBI
HuRef959,937,471 - 60,147,991 (+)NCBI
CHM1_1990,259,940 - 90,471,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004938   ⟹   NP_004929
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,867 - 87,708,634 (+)NCBI
GRCh37990,112,601 - 90,323,566 (+)NCBI
Build 36989,302,576 - 89,513,369 (+)NCBI Archive
HuRef959,937,471 - 60,147,991 (+)NCBI
CHM1_1990,260,393 - 90,471,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005251757   ⟹   XP_005251814
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,841 - 87,687,291 (+)NCBI
GRCh37990,112,601 - 90,323,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017014360   ⟹   XP_016869849
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,647,796 - 87,708,634 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004929   ⟸   NM_004938
- UniProtKB: P53355 (UniProtKB/Swiss-Prot),   B4DHI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005251814   ⟸   XM_005251757
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001275660   ⟸   NM_001288731
- UniProtKB: P53355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275659   ⟸   NM_001288730
- UniProtKB: P53355 (UniProtKB/Swiss-Prot),   Q59H88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275658   ⟸   NM_001288729
- UniProtKB: P53355 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016869849   ⟸   XM_017014360
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000484267   ⟸   ENST00000622514
RefSeq Acc Id: ENSP00000419026   ⟸   ENST00000491893
RefSeq Acc Id: ENSP00000418885   ⟸   ENST00000469640
RefSeq Acc Id: ENSP00000386135   ⟸   ENST00000408954
RefSeq Acc Id: ENSP00000417076   ⟸   ENST00000472284
RefSeq Acc Id: ENSP00000417746   ⟸   ENST00000489291
RefSeq Acc Id: ENSP00000350785   ⟸   ENST00000358077
Protein Domains
ANK_REP_REGION   Death   Protein kinase   Roc

Promoters
RGD ID:7215383
Promoter ID:EPDNEW_H13438
Type:initiation region
Name:DAPK1_4
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13439  EPDNEW_H13440  EPDNEW_H13441  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,228 - 87,497,288EPDNEW
RGD ID:7215385
Promoter ID:EPDNEW_H13439
Type:initiation region
Name:DAPK1_1
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13438  EPDNEW_H13440  EPDNEW_H13441  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,737 - 87,497,797EPDNEW
RGD ID:7215387
Promoter ID:EPDNEW_H13440
Type:initiation region
Name:DAPK1_2
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13438  EPDNEW_H13439  EPDNEW_H13441  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,497,872 - 87,497,932EPDNEW
RGD ID:7215403
Promoter ID:EPDNEW_H13441
Type:initiation region
Name:DAPK1_3
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13438  EPDNEW_H13439  EPDNEW_H13440  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38987,498,926 - 87,498,986EPDNEW
RGD ID:6807611
Promoter ID:HG_KWN:63903
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000358077,   ENST00000408954,   NM_004938,   OTTHUMT00000052946,   UC004APC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36989,302,506 - 89,303,417 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q21.33-22.2(chr9:87418580-90406012)x1 copy number loss See cases [RCV000050968] Chr9:87418580..90406012 [GRCh38]
Chr9:90033495..93168294 [GRCh37]
Chr9:89223315..92208114 [NCBI36]
Chr9:9q21.33-22.2
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
NM_004938.3(DAPK1):c.62+25112G>C single nucleotide variant Lung cancer [RCV000108469] Chr9:87524251 [GRCh38]
Chr9:90139166 [GRCh37]
Chr9:9q21.33
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2
pathogenic
GRCh38/hg38 9q21.33-22.31(chr9:86079851-91827221)x1 copy number loss See cases [RCV000137602] Chr9:86079851..91827221 [GRCh38]
Chr9:88694766..94589503 [GRCh37]
Chr9:87884586..93629324 [NCBI36]
Chr9:9q21.33-22.31
pathogenic
GRCh38/hg38 9q21.33-22.1(chr9:87209403-87977877)x3 copy number gain See cases [RCV000138224] Chr9:87209403..87977877 [GRCh38]
Chr9:89824318..90592792 [GRCh37]
Chr9:89014138..89782612 [NCBI36]
Chr9:9q21.33-22.1
uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9p24.3-q22.1(chr9:203861-88130444)x4 copy number gain See cases [RCV000141904] Chr9:203861..88130444 [GRCh38]
Chr9:203861..90745359 [GRCh37]
Chr9:193861..89935179 [NCBI36]
Chr9:9p24.3-q22.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9q21.11-22.1(chr9:70966262-90761254)x4 copy number gain See cases [RCV000512280] Chr9:70966262..90761254 [GRCh37]
Chr9:9q21.11-22.1
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
t(1;9)(p36.3;q23)dn translocation not specified [RCV000714246] Chr1:23253920..23253925 [GRCh37]
Chr9:90222713 [GRCh37]
Chr1:1p36.12
Chr9:9q21.33
uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_004938.4(DAPK1):c.1209G>A (p.Ser403=) single nucleotide variant not provided [RCV000961949] Chr9:87646538 [GRCh38]
Chr9:90261453 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.4164C>T (p.Ala1388=) single nucleotide variant not provided [RCV000920738] Chr9:87707235 [GRCh38]
Chr9:90322150 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.919-10T>A single nucleotide variant not provided [RCV000883882] Chr9:87643366 [GRCh38]
Chr9:90258281 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.3816G>T (p.Met1272Ile) single nucleotide variant not provided [RCV000964506] Chr9:87706887 [GRCh38]
Chr9:90321802 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.919-9A>T single nucleotide variant not provided [RCV000884452] Chr9:87643367 [GRCh38]
Chr9:90258282 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.366A>G (p.Gln122=) single nucleotide variant not provided [RCV000965791] Chr9:87638024 [GRCh38]
Chr9:90252939 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.2400C>T (p.Asn800=) single nucleotide variant not provided [RCV000906593] Chr9:87686726 [GRCh38]
Chr9:90301641 [GRCh37]
Chr9:9q21.33
likely benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
NM_004938.4(DAPK1):c.1132-7A>G single nucleotide variant not provided [RCV000880875] Chr9:87646454 [GRCh38]
Chr9:90261369 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.3864C>T (p.His1288=) single nucleotide variant not provided [RCV000917093] Chr9:87706935 [GRCh38]
Chr9:90321850 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.1293C>T (p.Leu431=) single nucleotide variant not provided [RCV000961950] Chr9:87647367 [GRCh38]
Chr9:90262282 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.4214G>T (p.Gly1405Val) single nucleotide variant not provided [RCV000965111] Chr9:87707285 [GRCh38]
Chr9:90322200 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.1725G>A (p.Arg575=) single nucleotide variant not provided [RCV000925241] Chr9:87651625 [GRCh38]
Chr9:90266540 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.3876A>G (p.Ser1292=) single nucleotide variant not provided [RCV000950176] Chr9:87706947 [GRCh38]
Chr9:90321862 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.33T>C (p.Asp11=) single nucleotide variant not provided [RCV000976622] Chr9:87499110 [GRCh38]
Chr9:90114025 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.783-9C>G single nucleotide variant not provided [RCV000965110] Chr9:87640793 [GRCh38]
Chr9:90255708 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.4041C>T (p.Asn1347=) single nucleotide variant not provided [RCV000968852] Chr9:87707112 [GRCh38]
Chr9:90322027 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.285-6T>C single nucleotide variant not provided [RCV000885908] Chr9:87637937 [GRCh38]
Chr9:90252852 [GRCh37]
Chr9:9q21.33
benign
GRCh37/hg19 9q21.2-22.32(chr9:79520825-97201274) copy number gain not provided [RCV000767645] Chr9:79520825..97201274 [GRCh37]
Chr9:9q21.2-22.32
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
NM_004938.4(DAPK1):c.4043G>T (p.Gly1348Val) single nucleotide variant not provided [RCV000915764] Chr9:87707114 [GRCh38]
Chr9:90322029 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.639G>A (p.Gly213=) single nucleotide variant not provided [RCV000979666] Chr9:87640307 [GRCh38]
Chr9:90255222 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.1131+9C>T single nucleotide variant not provided [RCV000885909] Chr9:87646023 [GRCh38]
Chr9:90260938 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.1971C>T (p.His657=) single nucleotide variant not provided [RCV000885910] Chr9:87668644 [GRCh38]
Chr9:90283559 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.3061-4G>A single nucleotide variant not provided [RCV000954409] Chr9:87706128 [GRCh38]
Chr9:90321043 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.42C>T (p.Asp14=) single nucleotide variant not provided [RCV000949949] Chr9:87499119 [GRCh38]
Chr9:90114034 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.2976G>T (p.Val992=) single nucleotide variant not provided [RCV000908186] Chr9:87703133 [GRCh38]
Chr9:90318048 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.1231-6C>G single nucleotide variant not provided [RCV000956727] Chr9:87647299 [GRCh38]
Chr9:90262214 [GRCh37]
Chr9:9q21.33
benign
NM_004938.4(DAPK1):c.1972G>T (p.Val658Leu) single nucleotide variant not provided [RCV000891511] Chr9:87668645 [GRCh38]
Chr9:90283560 [GRCh37]
Chr9:9q21.33
likely benign
NM_004938.4(DAPK1):c.919-10_919-9insTA insertion not provided [RCV000956726] Chr9:87643366..87643367 [GRCh38]
Chr9:90258281..90258282 [GRCh37]
Chr9:9q21.33
benign
GRCh37/hg19 9q21.33-22.31(chr9:90002910-94567835)x3 copy number gain not provided [RCV001006243] Chr9:90002910..94567835 [GRCh37]
Chr9:9q21.33-22.31
likely pathogenic
GRCh37/hg19 9q21.33-22.2(chr9:90031614-93173691)x1 copy number loss not provided [RCV001258443] Chr9:90031614..93173691 [GRCh37]
Chr9:9q21.33-22.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2674 AgrOrtholog
COSMIC DAPK1 COSMIC
Ensembl Genes ENSG00000196730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000350785 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386135 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417076 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000417746 UniProtKB/TrEMBL
  ENSP00000418885 UniProtKB/Swiss-Prot
  ENSP00000419026 UniProtKB/Swiss-Prot
  ENSP00000484267 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000358077 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000408954 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000469640 UniProtKB/Swiss-Prot
  ENST00000472284 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000489291 UniProtKB/TrEMBL
  ENST00000491893 UniProtKB/Swiss-Prot
  ENST00000622514 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000196730 GTEx
HGNC ID HGNC:2674 ENTREZGENE
Human Proteome Map DAPK1 Human Proteome Map
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAPK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1612 UniProtKB/Swiss-Prot
NCBI Gene 1612 ENTREZGENE
OMIM 600831 OMIM
PANTHER PTHR24342:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27142 PharmGKB
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0T398_HUMAN UniProtKB/TrEMBL
  B4DHI4 ENTREZGENE, UniProtKB/TrEMBL
  DAPK1_HUMAN UniProtKB/Swiss-Prot
  F8WCQ3_HUMAN UniProtKB/TrEMBL
  P53355 ENTREZGENE
  Q59H88 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7ZLD2 UniProtKB/Swiss-Prot
  B7ZLE7 UniProtKB/Swiss-Prot
  Q14CQ7 UniProtKB/Swiss-Prot
  Q1W5W0 UniProtKB/Swiss-Prot
  Q68CP8 UniProtKB/Swiss-Prot
  Q6ZRZ3 UniProtKB/Swiss-Prot
  Q9BTL8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 DAPK1  death associated protein kinase 1    death-associated protein kinase 1  Symbol and/or name change 5135510 APPROVED