MCRS1 (microspherule protein 1) - Rat Genome Database

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Pathways
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Gene: MCRS1 (microspherule protein 1) Homo sapiens
Analyze
Symbol: MCRS1
Name: microspherule protein 1
RGD ID: 1323153
HGNC Page HGNC:6960
Description: Enables RNA binding activity and telomerase inhibitor activity. Involved in several processes, including chromatin remodeling; positive regulation of protein localization to nucleolus; and regulation of nucleobase-containing compound metabolic process. Located in NSL complex; cytoplasm; and nuclear lumen. Part of MLL1 complex and histone acetyltransferase complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; INO80 complex subunit Q; INO80Q; MCRS2; MSP58; P78
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,558,299 - 49,568,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,556,544 - 49,568,145 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,952,082 - 49,961,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,238,352 - 48,248,178 (-)NCBINCBI36Build 36hg18NCBI36
Build 341248,238,352 - 48,248,178NCBI
Celera1248,746,544 - 48,756,370 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,982,929 - 46,992,780 (-)NCBIHuRef
CHM1_11249,918,314 - 49,928,165 (-)NCBICHM1_1
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,TAS)
dendrite  (IEA,ISO,ISS)
histone acetyltransferase complex  (IDA)
Ino80 complex  (IDA,IEA)
MLL1 complex  (IDA,IEA)
NSL complex  (IBA,IDA)
nucleolus  (IDA,IEA)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,IEA)
perikaryon  (IEA,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
Additional References at PubMed
PMID:9654073   PMID:9765390   PMID:10196275   PMID:11948183   PMID:12477932   PMID:14667819   PMID:15044100   PMID:15231747   PMID:15345747   PMID:15489334   PMID:15659546   PMID:15719173  
PMID:15829507   PMID:15960975   PMID:16186106   PMID:16189514   PMID:16230350   PMID:16547491   PMID:16565220   PMID:16571602   PMID:16964243   PMID:17014843   PMID:17081983   PMID:17109818  
PMID:17353931   PMID:17721549   PMID:18029348   PMID:18798870   PMID:18922472   PMID:19060904   PMID:19187526   PMID:19549253   PMID:20018852   PMID:20360068   PMID:20479123   PMID:21303910  
PMID:21533551   PMID:21653829   PMID:21873635   PMID:22081094   PMID:22563078   PMID:22609355   PMID:22773039   PMID:22975844   PMID:22990118   PMID:22994740   PMID:23069210   PMID:23225332  
PMID:23455924   PMID:23519485   PMID:23996240   PMID:24244196   PMID:24361335   PMID:24453475   PMID:24842875   PMID:24981860   PMID:25016522   PMID:25184681   PMID:25373388   PMID:25416956  
PMID:25609649   PMID:25981436   PMID:26186194   PMID:26300492   PMID:26340092   PMID:26467212   PMID:26496610   PMID:26638075   PMID:26673895   PMID:26849376   PMID:27192185   PMID:27263857  
PMID:27468560   PMID:27530925   PMID:27637333   PMID:27641337   PMID:27705803   PMID:28448870   PMID:28514442   PMID:29509190   PMID:30021884   PMID:30480076   PMID:30785839   PMID:30804502  
PMID:30953699   PMID:31140612   PMID:31182584   PMID:31515488   PMID:31527615   PMID:31753913   PMID:32296183   PMID:32509391   PMID:32814053   PMID:33187986   PMID:33226137   PMID:33640491  
PMID:33961781   PMID:34373451   PMID:35140242   PMID:35914814   PMID:36350698   PMID:36384428   PMID:36537216   PMID:36949045  


Genomics

Comparative Map Data
MCRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,558,299 - 49,568,142 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,556,544 - 49,568,145 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,952,082 - 49,961,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,238,352 - 48,248,178 (-)NCBINCBI36Build 36hg18NCBI36
Build 341248,238,352 - 48,248,178NCBI
Celera1248,746,544 - 48,756,370 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,982,929 - 46,992,780 (-)NCBIHuRef
CHM1_11249,918,314 - 49,928,165 (-)NCBICHM1_1
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBIT2T-CHM13v2.0
Mcrs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,140,698 - 99,149,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,140,698 - 99,149,842 (-)EnsemblGRCm39 Ensembl
GRCm381599,242,817 - 99,251,961 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,242,817 - 99,251,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv371599,073,248 - 99,082,392 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,070,854 - 99,079,967 (-)NCBIMGSCv36mm8
Celera15101,398,527 - 101,407,671 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.09NCBI
Mcrs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,262,719 - 132,271,533 (-)NCBIGRCr8
mRatBN7.27130,383,853 - 130,392,667 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,383,853 - 130,392,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,193,830 - 132,202,646 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,419,409 - 134,428,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,331,919 - 134,340,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,910,420 - 140,919,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,910,423 - 140,919,234 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,414,774 - 115,423,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,002,551 - 138,011,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,079,213 - 138,087,806 (-)NCBI
Celera7126,866,681 - 126,874,120 (-)NCBICelera
Cytogenetic Map7q36NCBI
Mcrs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547178,301 - 189,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955547180,783 - 189,980 (-)NCBIChiLan1.0ChiLan1.0
MCRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,616,544 - 44,626,408 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,612,895 - 44,623,169 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,183,112 - 39,192,925 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,073,860 - 40,083,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,073,860 - 40,083,655 (+)Ensemblpanpan1.1panPan2
MCRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,076,075 - 5,085,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,076,470 - 5,085,488 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,173,380 - 41,182,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,124,907 - 5,134,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,125,245 - 5,134,295 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,090,764 - 5,100,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,080,322 - 5,089,690 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,567,101 - 41,576,478 (-)NCBIUU_Cfam_GSD_1.0
Mcrs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,877,421 - 65,887,087 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,276,584 - 7,287,427 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,277,739 - 7,287,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,517,032 - 15,526,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,517,028 - 15,526,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,923,507 - 15,932,634 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCRS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,801,520 - 45,811,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,798,495 - 45,811,771 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,313,701 - 200,323,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcrs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248162,673,058 - 2,683,306 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MCRS1
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p11.21-q13.12(chr12:31886971-50360461)x3 copy number gain See cases [RCV000207454] Chr12:31886971..50360461 [GRCh37]
Chr12:12p11.21-q13.12		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_006337.5(MCRS1):c.1217A>G (p.Asn406Ser) single nucleotide variant Inborn genetic diseases [RCV003277641] Chr12:49558928 [GRCh38]
Chr12:49952711 [GRCh37]
Chr12:12q13.12		 uncertain significance
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:49024019-50299974)x3 copy number gain not provided [RCV001259140] Chr12:49024019..50299974 [GRCh37]
Chr12:12q13.11-13.12		 uncertain significance
NM_006337.5(MCRS1):c.47C>T (p.Ser16Leu) single nucleotide variant Inborn genetic diseases [RCV002749871] Chr12:49566179 [GRCh38]
Chr12:49959962 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.928C>T (p.Arg310Trp) single nucleotide variant Inborn genetic diseases [RCV002951866] Chr12:49559804 [GRCh38]
Chr12:49953587 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.11-217G>A single nucleotide variant Inborn genetic diseases [RCV002739174] Chr12:49566432 [GRCh38]
Chr12:49960215 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.529G>A (p.Ala177Thr) single nucleotide variant Inborn genetic diseases [RCV002797823] Chr12:49564509 [GRCh38]
Chr12:49958292 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.269C>T (p.Ser90Phe) single nucleotide variant Inborn genetic diseases [RCV002808761] Chr12:49565548 [GRCh38]
Chr12:49959331 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.769C>T (p.Leu257Phe) single nucleotide variant Inborn genetic diseases [RCV002669488] Chr12:49563037 [GRCh38]
Chr12:49956820 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.749C>T (p.Ala250Val) single nucleotide variant Inborn genetic diseases [RCV002835985] Chr12:49563057 [GRCh38]
Chr12:49956840 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.98G>A (p.Arg33Gln) single nucleotide variant Inborn genetic diseases [RCV003184948] Chr12:49566128 [GRCh38]
Chr12:49959911 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.627T>G (p.Phe209Leu) single nucleotide variant Inborn genetic diseases [RCV003202994] Chr12:49563477 [GRCh38]
Chr12:49957260 [GRCh37]
Chr12:12q13.12		 uncertain significance
NM_006337.5(MCRS1):c.779A>T (p.Gln260Leu) single nucleotide variant Inborn genetic diseases [RCV003265382] Chr12:49563027 [GRCh38]
Chr12:49956810 [GRCh37]
Chr12:12q13.12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5555
Count of miRNA genes:1034
Interacting mature miRNAs:1329
Transcripts:ENST00000343810, ENST00000357123, ENST00000546244, ENST00000547182, ENST00000548334, ENST00000548596, ENST00000548602, ENST00000548646, ENST00000549000, ENST00000549528, ENST00000550165, ENST00000551598, ENST00000551625, ENST00000552206, ENST00000552596, ENST00000553173
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-AA099057  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,961,159 - 49,961,347UniSTSGRCh37
Build 361248,247,426 - 48,247,614RGDNCBI36
Celera1248,755,618 - 48,755,806RGD
Cytogenetic Map12q13.12UniSTS
HuRef1246,992,011 - 46,992,199UniSTS
GeneMap99-GB4 RH Map12220.33UniSTS
RH41888  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,952,158 - 49,952,343UniSTSGRCh37
Build 361248,238,425 - 48,238,610RGDNCBI36
Celera1248,746,617 - 48,746,802RGD
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map12q13UniSTS
HuRef1246,983,010 - 46,983,195UniSTS
GeneMap99-GB4 RH Map12220.22UniSTS
MCRS1_9110  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,952,075 - 49,952,499UniSTSGRCh37
Build 361248,238,342 - 48,238,766RGDNCBI36
Celera1248,746,534 - 48,746,958RGD
HuRef1246,982,927 - 46,983,351UniSTS
STS-F09935  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,952,273 - 49,952,350UniSTSGRCh37
Build 361248,238,540 - 48,238,617RGDNCBI36
Celera1248,746,732 - 48,746,809RGD
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map12q13UniSTS
HuRef1246,983,125 - 46,983,202UniSTS
GeneMap99-GB4 RH Map12219.46UniSTS
NCBI RH Map12447.5UniSTS
RH77809  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13.12UniSTS
GeneMap99-GB4 RH Map12218.26UniSTS
NCBI RH Map12448.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2435 2846 1687 585 1853 426 4356 2150 3620 418 1459 1613 175 1 1204 2787 6 2
Low 4 145 39 39 98 39 1 47 114 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001748555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC020612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF068007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY336730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY078747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  R66413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000343810   ⟹   ENSP00000345358
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,299 - 49,568,142 (-)Ensembl
RefSeq Acc Id: ENST00000357123   ⟹   ENSP00000349640
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,643 - 49,566,439 (-)Ensembl
RefSeq Acc Id: ENST00000546244   ⟹   ENSP00000444982
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,295 - 49,568,145 (-)Ensembl
RefSeq Acc Id: ENST00000547182
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,573 - 49,563,075 (-)Ensembl
RefSeq Acc Id: ENST00000548334   ⟹   ENSP00000450352
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,563,487 - 49,567,832 (-)Ensembl
RefSeq Acc Id: ENST00000548596   ⟹   ENSP00000449343
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,564,481 - 49,567,873 (-)Ensembl
RefSeq Acc Id: ENST00000548602   ⟹   ENSP00000447739
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,301 - 49,568,131 (-)Ensembl
RefSeq Acc Id: ENST00000548646   ⟹   ENSP00000448700
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,504 - 49,559,780 (-)Ensembl
RefSeq Acc Id: ENST00000549000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,559,013 - 49,568,132 (-)Ensembl
RefSeq Acc Id: ENST00000549528   ⟹   ENSP00000447592
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,564,763 - 49,567,850 (-)Ensembl
RefSeq Acc Id: ENST00000550165   ⟹   ENSP00000448056
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,363 - 49,568,101 (-)Ensembl
RefSeq Acc Id: ENST00000551598   ⟹   ENSP00000448947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,556,544 - 49,560,302 (-)Ensembl
RefSeq Acc Id: ENST00000551625
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,302 - 49,567,750 (-)Ensembl
RefSeq Acc Id: ENST00000552206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,565,530 - 49,568,128 (-)Ensembl
RefSeq Acc Id: ENST00000552596
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,558,479 - 49,559,260 (-)Ensembl
RefSeq Acc Id: ENST00000553173   ⟹   ENSP00000447514
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1249,559,738 - 49,568,100 (-)Ensembl
RefSeq Acc Id: NM_001012300   ⟹   NP_001012300
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,302 - 49,566,439 (-)NCBI
GRCh371249,952,077 - 49,961,928 (-)NCBI
Build 361248,238,352 - 48,246,489 (-)NCBI Archive
HuRef1246,982,929 - 46,992,780 (-)NCBI
CHM1_11249,918,322 - 49,926,459 (-)NCBI
T2T-CHM13v2.01249,520,558 - 49,528,695 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001278341   ⟹   NP_001265270
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,299 - 49,568,142 (-)NCBI
HuRef1246,982,929 - 46,992,780 (-)NCBI
CHM1_11249,918,314 - 49,928,165 (-)NCBI
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006337   ⟹   NP_006328
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,299 - 49,568,142 (-)NCBI
GRCh371249,952,077 - 49,961,928 (-)NCBI
Build 361248,238,352 - 48,248,178 (-)NCBI Archive
HuRef1246,982,929 - 46,992,780 (-)NCBI
CHM1_11249,918,314 - 49,928,165 (-)NCBI
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005268572   ⟹   XP_005268629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,299 - 49,568,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537760   ⟹   XP_011536062
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,299 - 49,568,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018690   ⟹   XP_016874179
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,558,299 - 49,568,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047428083   ⟹   XP_047284039
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,559,939 - 49,568,142 (-)NCBI
RefSeq Acc Id: XM_054370773   ⟹   XP_054226748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBI
RefSeq Acc Id: XM_054370774   ⟹   XP_054226749
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBI
RefSeq Acc Id: XM_054370775   ⟹   XP_054226750
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01249,520,555 - 49,530,398 (-)NCBI
RefSeq Acc Id: XM_054370776   ⟹   XP_054226751
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01249,522,195 - 49,530,398 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012300 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265270 (Get FASTA)   NCBI Sequence Viewer  
  NP_006328 (Get FASTA)   NCBI Sequence Viewer  
  XP_005268629 (Get FASTA)   NCBI Sequence Viewer  
  XP_011536062 (Get FASTA)   NCBI Sequence Viewer  
  XP_016874179 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284039 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226748 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226749 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226750 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226751 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52086 (Get FASTA)   NCBI Sequence Viewer  
  AAC68599 (Get FASTA)   NCBI Sequence Viewer  
  AAH11794 (Get FASTA)   NCBI Sequence Viewer  
  AAQ84517 (Get FASTA)   NCBI Sequence Viewer  
  CAD98003 (Get FASTA)   NCBI Sequence Viewer  
  CCQ43031 (Get FASTA)   NCBI Sequence Viewer  
  EAW58075 (Get FASTA)   NCBI Sequence Viewer  
  EAW58076 (Get FASTA)   NCBI Sequence Viewer  
  EAW58077 (Get FASTA)   NCBI Sequence Viewer  
  EAW58078 (Get FASTA)   NCBI Sequence Viewer  
  EAW58079 (Get FASTA)   NCBI Sequence Viewer  
  EAW58080 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000345358
  ENSP00000345358.4
  ENSP00000349640
  ENSP00000349640.4
  ENSP00000444982
  ENSP00000444982.1
  ENSP00000447514
  ENSP00000447514.1
  ENSP00000447592.1
  ENSP00000447739.1
  ENSP00000448056
  ENSP00000448056.1
  ENSP00000448700.1
  ENSP00000448947.1
  ENSP00000449343.1
  ENSP00000450352.1
GenBank Protein Q96EZ8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_006328   ⟸   NM_006337
- Peptide Label: isoform 1
- UniProtKB: Q6VN53 (UniProtKB/Swiss-Prot),   O75497 (UniProtKB/Swiss-Prot),   O14742 (UniProtKB/Swiss-Prot),   Q7Z372 (UniProtKB/Swiss-Prot),   Q96EZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001012300   ⟸   NM_001012300
- Peptide Label: isoform 2
- UniProtKB: Q96EZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265270   ⟸   NM_001278341
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: XP_005268629   ⟸   XM_005268572
- Peptide Label: isoform X3
- UniProtKB: Q6VN53 (UniProtKB/Swiss-Prot),   O75497 (UniProtKB/Swiss-Prot),   O14742 (UniProtKB/Swiss-Prot),   Q7Z372 (UniProtKB/Swiss-Prot),   Q96EZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011536062   ⟸   XM_011537760
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016874179   ⟸   XM_017018690
- Peptide Label: isoform X2
- UniProtKB: Q96EZ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000444982   ⟸   ENST00000546244
RefSeq Acc Id: ENSP00000447739   ⟸   ENST00000548602
RefSeq Acc Id: ENSP00000448700   ⟸   ENST00000548646
RefSeq Acc Id: ENSP00000449343   ⟸   ENST00000548596
RefSeq Acc Id: ENSP00000450352   ⟸   ENST00000548334
RefSeq Acc Id: ENSP00000447592   ⟸   ENST00000549528
RefSeq Acc Id: ENSP00000448056   ⟸   ENST00000550165
RefSeq Acc Id: ENSP00000448947   ⟸   ENST00000551598
RefSeq Acc Id: ENSP00000447514   ⟸   ENST00000553173
RefSeq Acc Id: ENSP00000345358   ⟸   ENST00000343810
RefSeq Acc Id: ENSP00000349640   ⟸   ENST00000357123
RefSeq Acc Id: XP_047284039   ⟸   XM_047428083
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054226748   ⟸   XM_054370773
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054226750   ⟸   XM_054370775
- Peptide Label: isoform X3
- UniProtKB: Q7Z372 (UniProtKB/Swiss-Prot),   Q96EZ8 (UniProtKB/Swiss-Prot),   Q6VN53 (UniProtKB/Swiss-Prot),   O75497 (UniProtKB/Swiss-Prot),   O14742 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054226749   ⟸   XM_054370774
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054226751   ⟸   XM_054370776
- Peptide Label: isoform X4
Protein Domains
FHA   Microspherule protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96EZ8-F1-model_v2 AlphaFold Q96EZ8 1-462 view protein structure

Promoters
RGD ID:6790243
Promoter ID:HG_KWN:15564
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006337,   UC001RUJ.1,   UC001RUL.1,   UC001RUM.1,   UC001RUN.1,   UC009ZLJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361248,247,941 - 48,248,612 (-)MPROMDB
RGD ID:7223843
Promoter ID:EPDNEW_H17667
Type:initiation region
Name:MCRS1_1
Description:microspherule protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381249,568,132 - 49,568,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6960 AgrOrtholog
COSMIC MCRS1 COSMIC
Ensembl Genes ENSG00000187778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000343810 ENTREZGENE
  ENST00000343810.9 UniProtKB/Swiss-Prot
  ENST00000357123 ENTREZGENE
  ENST00000357123.8 UniProtKB/Swiss-Prot
  ENST00000546244 ENTREZGENE
  ENST00000546244.5 UniProtKB/Swiss-Prot
  ENST00000548334.5 UniProtKB/TrEMBL
  ENST00000548596.5 UniProtKB/TrEMBL
  ENST00000548602.5 UniProtKB/TrEMBL
  ENST00000548646.5 UniProtKB/TrEMBL
  ENST00000549528.1 UniProtKB/TrEMBL
  ENST00000550165 ENTREZGENE
  ENST00000550165.5 UniProtKB/Swiss-Prot
  ENST00000551598.5 UniProtKB/TrEMBL
  ENST00000551625 ENTREZGENE
  ENST00000553173 ENTREZGENE
  ENST00000553173.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000187778 GTEx
HGNC ID HGNC:6960 ENTREZGENE
Human Proteome Map MCRS1 Human Proteome Map
InterPro FHA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCRS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCRS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10445 UniProtKB/Swiss-Prot
NCBI Gene 10445 ENTREZGENE
OMIM 609504 OMIM
PANTHER MICROSPHERULE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCRS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30708 PharmGKB
PROSITE FHA_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8VP44_HUMAN UniProtKB/TrEMBL
  F8VVA6_HUMAN UniProtKB/TrEMBL
  F8VZC2_HUMAN UniProtKB/TrEMBL
  F8W0I9_HUMAN UniProtKB/TrEMBL
  F8W126_HUMAN UniProtKB/TrEMBL
  H0YI67_HUMAN UniProtKB/TrEMBL
  H0YIA0_HUMAN UniProtKB/TrEMBL
  L8E8H6_HUMAN UniProtKB/TrEMBL
  MCRS1_HUMAN UniProtKB/Swiss-Prot
  O14742 ENTREZGENE
  O75497 ENTREZGENE
  Q6VN53 ENTREZGENE
  Q7Z372 ENTREZGENE
  Q96EZ8 ENTREZGENE
UniProt Secondary O14742 UniProtKB/Swiss-Prot
  O75497 UniProtKB/Swiss-Prot
  Q6VN53 UniProtKB/Swiss-Prot
  Q7Z372 UniProtKB/Swiss-Prot