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Gene: ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13) Homo sapiens
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Symbol: ADAMTS13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Description: Predicted to have integrin binding activity; metal ion binding activity; and metallopeptidase activity. Involved in peptide catabolic process and proteolysis. Predicted to localize to the endoplasmic reticulum lumen and extracellular matrix. Implicated in thrombotic thrombocytopenic purpura. Biomarker of several diseases, including HELLP syndrome; Plasmodium falciparum malaria; liver disease (multiple); rheumatic disease (multiple); and thrombophilia (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 13; A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAM-TS; ADAM-TS 13; ADAM-TS13; ADAMTS-13; C9orf8; DKFZp434C2322; FLJ42993; MGC118899; MGC118900; TTP; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; VWFCP
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl9133,414,358 - 133,459,402 (+)EnsemblGRCh38hg38GRCh38
GRCh389133,414,339 - 133,459,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,279,459 - 136,324,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,276,941 - 135,314,328 (+)NCBINCBI36hg18NCBI36
Build 349133,316,673 - 133,344,631NCBI
Celera9106,830,032 - 106,875,101 (+)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9105,781,289 - 105,826,219 (+)NCBIHuRef
CHM1_19136,429,966 - 136,475,028 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ADAMTS13
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323132
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.