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Gene: TERF1 (telomeric repeat binding factor 1) Homo sapiens
Symbol: TERF1
Name: telomeric repeat binding factor 1
Description: Exhibits several functions, including DNA binding activity; ankyrin repeat binding activity; and protein dimerization activity. Contributes to telomerase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of organelle organization; and telomere maintenance. Localizes to the fibrillar center; nuclear body; and shelterin complex. Colocalizes with the spindle. Biomarker of breast cancer and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding protein 1; telomeric repeat-binding factor 1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1
Mus musculus (house mouse) : Terf1 (telomeric repeat binding factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Terf1 (telomeric repeat binding factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Terf1 (telomeric repeat binding factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TERF1 (telomeric repeat binding factor 1)
Canis lupus familiaris (dog) : TERF1 (telomeric repeat binding factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Terf1 (telomeric repeat binding factor 1)
Sus scrofa (pig) : TERF1 (telomeric repeat binding factor 1)
Chlorocebus sabaeus (African green monkey) : TERF1 (telomeric repeat binding factor 1)
Heterocephalus glaber (naked mole-rat) : Terf1 (telomeric repeat binding factor 1)
more info ...
Related Pseudogenes: TERF1P1   TERF1P2   TERF1P3   TERF1P4   TERF1P5   TERF1P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl873,008,864 - 73,048,123 (+)Ensembl
GRCh38873,008,856 - 73,048,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37873,921,097 - 73,959,987 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36874,083,661 - 74,122,281 (+)NCBINCBI36hg18NCBI36
Build 34874,083,662 - 74,122,281NCBI
Celera869,918,262 - 69,957,163 (+)NCBI
Cytogenetic Map8q21.11NCBI
HuRef869,411,980 - 69,450,876 (+)NCBIHuRef
CHM1_1873,973,943 - 74,012,842 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TERF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323104
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.