MMP28 (matrix metallopeptidase 28) - Rat Genome Database

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Gene: MMP28 (matrix metallopeptidase 28) Homo sapiens
Analyze
Symbol: MMP28
Name: matrix metallopeptidase 28
RGD ID: 1323102
HGNC Page HGNC:14366
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within negative regulation of macrophage chemotaxis. Located in collagen-containing extracellular matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: epilysin; matrix metalloprotease MMP25; matrix metalloproteinase 28; matrix metalloproteinase-28; MM28; MMP-25; MMP-28; MMP25; putative MMP28 gene product; uncharacterized protein LOC79148
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,756,249 - 35,795,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,756,249 - 35,795,707 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,083,268 - 34,122,645 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,116,989 - 31,146,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341731,116,988 - 31,146,741NCBI
Celera1731,003,010 - 31,032,922 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,278,035 - 30,307,831 (-)NCBIHuRef
CHM1_11734,157,411 - 34,187,192 (-)NCBICHM1_1
T2T-CHM13v2.01736,704,182 - 36,743,551 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11121398   PMID:11255011   PMID:11574168   PMID:12164918   PMID:12477932   PMID:12975309   PMID:14506071   PMID:14730609   PMID:15185874   PMID:15593191   PMID:15953044  
PMID:16344560   PMID:18778487   PMID:19375502   PMID:19379669   PMID:19921252   PMID:20003223   PMID:20144149   PMID:21152186   PMID:21615884   PMID:21723775   PMID:21801383   PMID:21873635  
PMID:22040290   PMID:23549873   PMID:23803888   PMID:23964118   PMID:24167355   PMID:24385575   PMID:24710352   PMID:25429835   PMID:26186194   PMID:27068509   PMID:28293015   PMID:28514442  
PMID:29373068   PMID:29729262   PMID:30021884   PMID:30913394   PMID:32268921   PMID:32296183   PMID:33191847   PMID:33961781   PMID:35256949  


Genomics

Comparative Map Data
MMP28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,756,249 - 35,795,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,756,249 - 35,795,707 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,083,268 - 34,122,645 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,116,989 - 31,146,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341731,116,988 - 31,146,741NCBI
Celera1731,003,010 - 31,032,922 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,278,035 - 30,307,831 (-)NCBIHuRef
CHM1_11734,157,411 - 34,187,192 (-)NCBICHM1_1
T2T-CHM13v2.01736,704,182 - 36,743,551 (-)NCBIT2T-CHM13v2.0
Mmp28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,331,594 - 83,353,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,331,594 - 83,353,897 (-)EnsemblGRCm39 Ensembl
GRCm381183,440,768 - 83,463,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,440,768 - 83,463,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,255,378 - 83,276,463 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,258,071 - 83,279,156 (-)NCBIMGSCv36mm8
Celera1193,036,503 - 93,057,585 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.39NCBI
Mmp28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,738,651 - 68,762,377 (-)NCBIGRCr8
mRatBN7.21068,241,138 - 68,264,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,241,138 - 68,264,866 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,863,750 - 72,884,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,369,134 - 72,390,115 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,833,186 - 67,854,165 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,660,691 - 70,681,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,660,691 - 70,681,672 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01071,122,715 - 71,143,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,526,718 - 71,547,699 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,541,276 - 71,562,259 (-)NCBI
Celera1067,185,212 - 67,206,220 (-)NCBICelera
Cytogenetic Map10q26NCBI
Mmp28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,207,704 - 10,232,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,207,704 - 10,242,666 (-)NCBIChiLan1.0ChiLan1.0
MMP28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,681,345 - 28,710,941 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,560,619 - 30,590,184 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,999,658 - 21,039,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,293,767 - 21,333,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,293,767 - 21,323,691 (+)Ensemblpanpan1.1panPan2
MMP28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,873,364 - 37,907,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,884,430 - 37,907,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,097,600 - 37,131,941 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,685,116 - 38,719,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,696,188 - 38,718,859 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,467,864 - 37,502,250 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,753,363 - 37,787,721 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,840,856 - 37,875,211 (+)NCBIUU_Cfam_GSD_1.0
Mmp28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,886,239 - 36,909,510 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936490165,376 - 188,823 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936490165,462 - 188,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,739,630 - 39,766,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,739,074 - 39,766,794 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MMP28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,241,938 - 29,272,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1629,240,569 - 29,272,077 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666075702,510 - 732,930 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,243,147 - 3,266,558 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,240,386 - 3,266,811 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP28
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_024302.4(MMP28):c.1419C>T (p.Pro473=) single nucleotide variant Malignant melanoma [RCV000071417] Chr17:35766644 [GRCh38]
Chr17:34093663 [GRCh37]
Chr17:31117776 [NCBI36]
Chr17:17q12
not provided
NM_024302.4(MMP28):c.890G>A (p.Gly297Glu) single nucleotide variant Malignant melanoma [RCV000071418] Chr17:35768340 [GRCh38]
Chr17:34095359 [GRCh37]
Chr17:31119472 [NCBI36]
Chr17:17q12
not provided
GRCh38/hg38 17q12(chr17:35129859-35767049)x3 copy number gain See cases [RCV000136983] Chr17:35129859..35767049 [GRCh38]
Chr17:33456878..34094068 [GRCh37]
Chr17:30480991..31118181 [NCBI36]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:32351496-34455576)x1 copy number loss not provided [RCV000683918] Chr17:32351496..34455576 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
NM_024302.5(MMP28):c.194C>T (p.Ala65Val) single nucleotide variant Inborn genetic diseases [RCV003252540] Chr17:35779073 [GRCh38]
Chr17:34106077 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.386C>T (p.Pro129Leu) single nucleotide variant Inborn genetic diseases [RCV002752285] Chr17:35764479 [GRCh38]
Chr17:34091498 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.511G>C (p.Ala171Pro) single nucleotide variant Inborn genetic diseases [RCV002778997] Chr17:35764604 [GRCh38]
Chr17:34091623 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.76G>A (p.Glu26Lys) single nucleotide variant Inborn genetic diseases [RCV002762609] Chr17:35764069 [GRCh38]
Chr17:34091088 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.314T>C (p.Leu105Pro) single nucleotide variant Inborn genetic diseases [RCV002886770] Chr17:35764307 [GRCh38]
Chr17:34091326 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.356C>T (p.Pro119Leu) single nucleotide variant Inborn genetic diseases [RCV002782234] Chr17:35764449 [GRCh38]
Chr17:34091468 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.185G>A (p.Gly62Asp) single nucleotide variant Inborn genetic diseases [RCV002956756] Chr17:35764178 [GRCh38]
Chr17:34091197 [GRCh37]
Chr17:17q12
uncertain significance
NM_145272.4(C17orf50):c.225G>C (p.Gln75His) single nucleotide variant Inborn genetic diseases [RCV002983425] Chr17:35764218 [GRCh38]
Chr17:34091237 [GRCh37]
Chr17:17q12
uncertain significance
NM_024302.5(MMP28):c.193G>A (p.Ala65Thr) single nucleotide variant Inborn genetic diseases [RCV002965439] Chr17:35779074 [GRCh38]
Chr17:34106078 [GRCh37]
Chr17:17q12
uncertain significance
NM_024302.5(MMP28):c.865G>A (p.Gly289Ser) single nucleotide variant Inborn genetic diseases [RCV003201785] Chr17:35768365 [GRCh38]
Chr17:34095384 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q11.2-12(chr17:30572862-35843988) copy number loss Chromosome 17q12 deletion syndrome [RCV003319594] Chr17:30572862..35843988 [GRCh37]
Chr17:17q11.2-12
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3793
Count of miRNA genes:857
Interacting mature miRNAs:1001
Transcripts:ENST00000250144, ENST00000587639, ENST00000587687, ENST00000587923, ENST00000589061, ENST00000589103, ENST00000590643, ENST00000593125
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1833  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,124,050 - 34,124,205UniSTSGRCh37
Build 361731,148,163 - 31,148,318RGDNCBI36
Celera1731,034,332 - 31,034,487RGD
Cytogenetic Map17q21.1UniSTS
HuRef1730,309,241 - 30,309,396UniSTS
Marshfield Genetic Map1757.71UniSTS
Marshfield Genetic Map1757.71RGD
Genethon Genetic Map1758.3UniSTS
deCODE Assembly Map1763.12UniSTS
MMP28_924.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,092,713 - 34,093,509UniSTSGRCh37
Build 361731,116,826 - 31,117,622RGDNCBI36
Celera1731,002,847 - 31,003,643RGD
HuRef1730,277,872 - 30,278,668UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1771 714 408 7 117 1 2994 819 1514 27 617 926 13 1001 1803
Low 531 1608 698 166 550 16 1035 1184 1974 128 558 399 152 203 938 2
Below cutoff 29 652 359 246 670 244 172 170 159 21 64 79 4 46

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001032278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_111988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017025064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054317183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA813101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC015849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF315683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF330002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF336346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM702847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA761282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA768574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY027589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000605424   ⟹   ENSP00000473853
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,765,865 - 35,795,641 (-)Ensembl
RefSeq Acc Id: ENST00000612292   ⟹   ENSP00000484562
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,768,315 - 35,779,311 (-)Ensembl
RefSeq Acc Id: ENST00000612672   ⟹   ENSP00000483539
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,778,505 - 35,795,707 (-)Ensembl
RefSeq Acc Id: ENST00000615136   ⟹   ENSP00000483299
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,766,340 - 35,795,624 (-)Ensembl
RefSeq Acc Id: ENST00000615317   ⟹   ENSP00000482385
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,756,249 - 35,768,326 (-)Ensembl
RefSeq Acc Id: ENST00000616383
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,778,505 - 35,779,368 (-)Ensembl
RefSeq Acc Id: ENST00000619655   ⟹   ENSP00000481051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1735,756,250 - 35,795,707 (-)Ensembl
RefSeq Acc Id: NM_001032278   ⟹   NP_001027449
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,778,505 - 35,795,641 (-)NCBI
GRCh371734,083,316 - 34,122,711 (-)NCBI
Build 361731,129,622 - 31,146,753 (-)NCBI Archive
HuRef1730,278,035 - 30,307,831 (-)ENTREZGENE
CHM1_11734,170,060 - 34,187,263 (-)NCBI
T2T-CHM13v2.01736,726,415 - 36,743,551 (-)NCBI
Sequence:
RefSeq Acc Id: NM_024302   ⟹   NP_077278
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
GRCh371734,083,316 - 34,122,711 (-)NCBI
Build 361731,116,989 - 31,146,753 (-)NCBI Archive
HuRef1730,278,035 - 30,307,831 (-)ENTREZGENE
CHM1_11734,157,411 - 34,187,263 (-)NCBI
T2T-CHM13v2.01736,713,803 - 36,743,551 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032950   ⟹   NP_116568
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
CHM1_11734,157,411 - 34,187,263 (-)NCBI
T2T-CHM13v2.01736,713,803 - 36,743,551 (-)NCBI
Sequence:
RefSeq Acc Id: NR_111988
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,756,249 - 35,795,641 (-)NCBI
CHM1_11734,147,803 - 34,187,263 (-)NCBI
T2T-CHM13v2.01736,704,182 - 36,743,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525225   ⟹   XP_011523527
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525226   ⟹   XP_011523528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525227   ⟹   XP_011523529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525229   ⟹   XP_011523531
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,263 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525230   ⟹   XP_011523532
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525231   ⟹   XP_011523533
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,756,249 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011525232   ⟹   XP_011523534
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017025063   ⟹   XP_016880552
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,766,678 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017025064   ⟹   XP_016880553
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,756,249 - 35,795,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024450943   ⟹   XP_024306711
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,780,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047436731   ⟹   XP_047292687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,765,865 - 35,795,254 (-)NCBI
RefSeq Acc Id: XM_054317173   ⟹   XP_054173148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317174   ⟹   XP_054173149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317175   ⟹   XP_054173150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,170 (-)NCBI
RefSeq Acc Id: XM_054317176   ⟹   XP_054173151
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317177   ⟹   XP_054173152
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,164 (-)NCBI
RefSeq Acc Id: XM_054317178   ⟹   XP_054173153
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,743,173 (-)NCBI
RefSeq Acc Id: XM_054317179   ⟹   XP_054173154
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,803 - 36,728,638 (-)NCBI
RefSeq Acc Id: XM_054317180   ⟹   XP_054173155
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,713,795 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317181   ⟹   XP_054173156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,704,182 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317182   ⟹   XP_054173157
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,714,616 - 36,743,551 (-)NCBI
RefSeq Acc Id: XM_054317183   ⟹   XP_054173158
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01736,704,182 - 36,743,551 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001027449 (Get FASTA)   NCBI Sequence Viewer  
  NP_077278 (Get FASTA)   NCBI Sequence Viewer  
  NP_116568 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523527 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523528 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523529 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523531 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523532 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523533 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523534 (Get FASTA)   NCBI Sequence Viewer  
  XP_016880552 (Get FASTA)   NCBI Sequence Viewer  
  XP_016880553 (Get FASTA)   NCBI Sequence Viewer  
  XP_024306711 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292687 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173148 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173149 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173150 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173151 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173152 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173153 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173154 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173155 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173156 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173157 (Get FASTA)   NCBI Sequence Viewer  
  XP_054173158 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG41981 (Get FASTA)   NCBI Sequence Viewer  
  AAH02631 (Get FASTA)   NCBI Sequence Viewer  
  AAH11774 (Get FASTA)   NCBI Sequence Viewer  
  AAK01480 (Get FASTA)   NCBI Sequence Viewer  
  AAK01706 (Get FASTA)   NCBI Sequence Viewer  
  AAL15619 (Get FASTA)   NCBI Sequence Viewer  
  AAQ89346 (Get FASTA)   NCBI Sequence Viewer  
  BAG53618 (Get FASTA)   NCBI Sequence Viewer  
  EAW80128 (Get FASTA)   NCBI Sequence Viewer  
  EAW80129 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000473853
  ENSP00000473853.1
  ENSP00000479124.1
  ENSP00000481051.1
  ENSP00000482385.1
  ENSP00000483299
  ENSP00000483299.1
  ENSP00000483539
  ENSP00000483539.1
  ENSP00000484430.1
  ENSP00000484562.1
  ENSP00000487783.1
  ENSP00000487847.1
  ENSP00000488096.1
  ENSP00000488159.1
GenBank Protein Q9H239 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077278   ⟸   NM_024302
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q96F04 (UniProtKB/Swiss-Prot),   Q96TE2 (UniProtKB/Swiss-Prot),   Q9H239 (UniProtKB/Swiss-Prot),   B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001027449   ⟸   NM_001032278
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9H239 (UniProtKB/Swiss-Prot),   B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_116568   ⟸   NM_032950
- Peptide Label: isoform 2 preproprotein
- UniProtKB: C0H5X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523533   ⟸   XM_011525231
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011523527   ⟸   XM_011525225
- Peptide Label: isoform X2
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523532   ⟸   XM_011525230
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011523528   ⟸   XM_011525226
- Peptide Label: isoform X3
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523531   ⟸   XM_011525229
- Peptide Label: isoform X3
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523529   ⟸   XM_011525227
- Peptide Label: isoform X3
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523534   ⟸   XM_011525232
- Peptide Label: isoform X1
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880553   ⟸   XM_017025064
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016880552   ⟸   XM_017025063
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_024306711   ⟸   XM_024450943
- Peptide Label: isoform X3
- UniProtKB: B3KV06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000484562   ⟸   ENST00000612292
RefSeq Acc Id: ENSP00000483539   ⟸   ENST00000612672
RefSeq Acc Id: ENSP00000482385   ⟸   ENST00000615317
RefSeq Acc Id: ENSP00000483299   ⟸   ENST00000615136
RefSeq Acc Id: ENSP00000481051   ⟸   ENST00000619655
RefSeq Acc Id: ENSP00000473853   ⟸   ENST00000605424
RefSeq Acc Id: XP_047292687   ⟸   XM_047436731
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173158   ⟸   XM_054317183
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054173156   ⟸   XM_054317181
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054173155   ⟸   XM_054317180
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054173149   ⟸   XM_054317174
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054173148   ⟸   XM_054317173
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054173151   ⟸   XM_054317176
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173153   ⟸   XM_054317178
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173150   ⟸   XM_054317175
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173152   ⟸   XM_054317177
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173154   ⟸   XM_054317179
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054173157   ⟸   XM_054317182
- Peptide Label: isoform X6
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H239-F1-model_v2 AlphaFold Q9H239 1-520 view protein structure

Promoters
RGD ID:6794017
Promoter ID:HG_KWN:25795
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000250144,   ENST00000338839,   NM_001032278,   NM_024302,   UC002HJW.1,   UC002HJZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361731,146,391 - 31,146,891 (-)MPROMDB
RGD ID:7234675
Promoter ID:EPDNEW_H23083
Type:initiation region
Name:MMP28_1
Description:matrix metallopeptidase 28
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381735,795,614 - 35,795,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14366 AgrOrtholog
COSMIC MMP28 COSMIC
Ensembl Genes ENSG00000271447 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000278843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000605424 ENTREZGENE
  ENST00000605424.6 UniProtKB/Swiss-Prot
  ENST00000611911.4 UniProtKB/Swiss-Prot
  ENST00000612292.1 UniProtKB/TrEMBL
  ENST00000612672 ENTREZGENE
  ENST00000612672.1 UniProtKB/Swiss-Prot
  ENST00000613289.2 UniProtKB/TrEMBL
  ENST00000615136 ENTREZGENE
  ENST00000615136.4 UniProtKB/TrEMBL
  ENST00000615317.4 UniProtKB/TrEMBL
  ENST00000619655 ENTREZGENE
  ENST00000619655.4 UniProtKB/TrEMBL
  ENST00000631999.1 UniProtKB/TrEMBL
  ENST00000632360.1 UniProtKB/Swiss-Prot
  ENST00000632913.1 UniProtKB/TrEMBL
  ENST00000634159.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.101.10 UniProtKB/TrEMBL
  2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000271447 GTEx
  ENSG00000278843 GTEx
HGNC ID HGNC:14366 ENTREZGENE
Human Proteome Map MMP28 Human Proteome Map
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBDSf UniProtKB/TrEMBL
KEGG Report hsa:79148 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79148 ENTREZGENE
OMIM 608417 OMIM
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATRIX METALLOPROTEINASE-28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30885 PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WZ56_HUMAN UniProtKB/TrEMBL
  A0A087X1Y9_HUMAN UniProtKB/TrEMBL
  A0A0J9YW29_HUMAN UniProtKB/TrEMBL
  B3KV06 ENTREZGENE, UniProtKB/TrEMBL
  C0H5X0 ENTREZGENE, UniProtKB/TrEMBL
  MMP28_HUMAN UniProtKB/Swiss-Prot
  Q96F04 ENTREZGENE
  Q96TE2 ENTREZGENE
  Q9H239 ENTREZGENE
UniProt Secondary Q96F04 UniProtKB/Swiss-Prot
  Q96TE2 UniProtKB/Swiss-Prot